AxonDeepSeg: automatic axon and myelin segmentation from microscopy data using convolutional neural networks [PDF]
, 2017 Segmentation of axon and myelin from microscopy images of the nervous system provides useful quantitative information about the tissue microstructure, such as axon density and myelin thickness. This could be used for instance to document cell morphometry
Antonsanti, Pierre-Louis +5 more
core +3 more sources
Myelin lipid metabolism and its role in myelination and myelin maintenance
The Innovation, 2023 Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high abundance of membrane lipids is one of myelin’s salient features that contribute to its unique role as an insulator that electrically isolates nerve fibers across ...
Joseph A. Barnes-Vélez +2 more
doaj +1 more source
Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy [PDF]
, 2017 Impairment of peripheral nerve function is frequent in neurometabolic diseases, but mechanistically not well understood. Here, we report a novel disease mechanism and the finding that glial lipid metabolism is critical for axon function, independent of ...
Asadollahi, Ebrahim +17 more
core +3 more sources
Myelin activates FAK/Akt/NF-kappaB pathways and provokes CR3-dependent inflammatory response in murine system. [PDF]
PLoS ONE, 2010 Inflammatory response following central nervous system (CNS) injury contributes to progressive neuropathology and reduction in functional recovery. Axons are sensitive to mechanical injury and toxic inflammatory mediators, which may lead to demyelination.
Xin Sun +11 more
doaj +1 more source
Neurobiology of Disease, 2022 Impaired bioenergetic capacity of the nervous system is thought to contribute to the pathogenesis of many neurodegenerative diseases (NDD). Since neuronal synapses are believed to be the major energy consumers in the nervous system, synaptic derangements
Bogdan Beirowski
doaj +1 more source
A Jones matrix formalism for simulating three-dimensional polarized light imaging of brain tissue [PDF]
, 2015 The neuroimaging technique three-dimensional polarized light imaging (3D-PLI) provides a high-resolution reconstruction of nerve fibres in human post-mortem brains.
Amunts, Katrin +5 more
core +4 more sources
Orphanet Journal of Rare Diseases, 2018 Background Infantile Sandhoff disease (ISD) is a GM2 gangliosidosis that is classified as a lysosomal storage disorder. The most common symptoms of affected individuals at presentation are neurologic involvement.
Ali Reza Tavasoli +5 more
doaj +1 more source
Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C. [PDF]
, 2013 VLGR1 (very large G protein-coupled receptor 1), also known as MASS1 (monogenic audiogenic seizure susceptible 1), is an orphan G protein-coupled receptor that contains a large extracellular N terminus with 35 calcium-binding domains.
Fu, Ying-Hui +3 more
core +1 more source
Vaccines, 2021 Myelin peptide–mannan conjugates have been shown to be potential vaccines in the immunotherapy of multiple sclerosis. The conjugates are comprised from the epitope peptide and the polysaccharide mannan which transfers as a carrier the antigenic peptide ...
John Matsoukas +8 more
doaj +1 more source
Measurement of T1 of the ultrashort T2* components in white matter of the brain at 3T. [PDF]
, 2013 Recent research demonstrates that white matter of the brain contains not only long T2 components, but a minority of ultrashort T2* components. Adiabatic inversion recovery prepared dual echo ultrashort echo time (IR-dUTE) sequences can be used to ...
Bydder, Graeme M +6 more
core +4 more sources