Results 11 to 20 of about 170,216 (297)

A Nanoscale Model System for the Human Myelin Sheath [PDF]

, 2021
Here, we for the first time establish nanodiscs with the challenging lipid composition of myelin of the peripheral or central nervous systems, respectively (PNS and CNS, both containing >40% cholesterol, which so far has been thought to be detrimental ...
David, Haselberger, Carla, Schmidt, Tommy, Hofmann, Annette, Meister, Panagiotis L., Kastritis, Lisa, Müller, Kevin, Janson, Carolyn, Vargas, Matthias, Hoffmann, Sandro, Keller, Dariush, Hinderberger, manabendra, das   +11 more
core   +2 more sources

Is Myelin Repair Possible? [PDF]

, 2022
In the body, myelin is the coating over the axons, the “wires'' carrying our body’s signals. The insulator around the wires acts the same way myelin acts as an insulator in the brain. The signals in the neurons of people diagnosed with multiple sclerosis
Polidoro, Madison, Balaji, Samhitha, Kovach, Emily, Spangler, Bailey, George, Caroline, Piniero, Matthew   +5 more
core   +1 more source

Myelination of parvalbumin interneurons shapes the function of cortical sensory inhibitory circuits

Nature Communications, 2020
Myelination optimizes conduction speed of excitatory neurons. However, whether myelination of interneurons (INs) refines cortical networks is unclear.
Najate Benamer, Marie Vidal, Maddalena Balia, María Cecilia Angulo   +3 more
doaj   +1 more source

Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis

ASN Neuro, 2022
Although over 20 disease modifying therapies are approved to treat Multiple Sclerosis (MS), these do not increase remyelination of demyelinated axons or mitigate axon damage.
Jeffrey L. Dupree, Pablo M. Paez, Seema K. Tiwari-Woodruff, Travis T. Denton, Kenneth Hensley, Christina G. Angeliu, Anne I. Boullerne, Sergey Kalinin, Sophia Egge, Veronica T. Cheli, Giancarlo Denaroso, Kelley C. Atkinson, Micah Feri, Douglas L. Feinstein   +13 more
doaj   +1 more source

Proteome Profile of Myelin in the Zebrafish Brain

Frontiers in Cell and Developmental Biology, 2021
The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice.
Sophie B. Siems, Olaf Jahn, Laura J. Hoodless, Ramona B. Jung, Dörte Hesse, Wiebke Möbius, Wiebke Möbius, Tim Czopka, Hauke B. Werner   +8 more
doaj   +1 more source

Differential expression and MAL-dependent targeting of the L-MAG and S-MAG isoforms to myelin membranes [PDF]

, 2003
Many degenerative diseases of the nervous system, including Multiple Sclerosis and peripheral neuropathies, are triggered by an impaired interaction between the axons and their surrounding myelin sheaths.
Erb, Michael
core   +1 more source

Symptomatic care of late-onset Alexander disease presenting with area postrema-like syndrome with prednisolone; a case report

BMC Pediatrics, 2022
Background Alexander disease (AxD) is classified into AxD type I (infantile) and AxD type II (juvenile and adult form). We aimed to determine the potential genetic cause(s) contributing to the AxD type II manifestations in a 9-year-old male who presented
Safoura Zardadi, Ehsan Razmara, Maryam Rasoulinezhad, Meisam Babaei, Mohammad Reza Ashrafi, Neda Pak, Masoud Garshasbi, Ali Reza Tavasoli   +7 more
doaj   +1 more source

The Human Myelin Proteome and Sub-Metalloproteome Interaction Map: Relevance to Myelin-Related Neurological Diseases

Brain Sciences, 2022
Myelin in humans is composed of about 80% lipids and 20% protein. Initially, myelin protein composition was considered low, but various recent proteome analyses have identified additional myelin proteins.
Christos T. Chasapis, Konstantinos Kelaidonis, Harry Ridgway, Vasso Apostolopoulos, John M. Matsoukas   +4 more
doaj   +1 more source

Functional role of the overexpression of the myelin and lymphocyte protein MAL in Schwann cells [PDF]

, 2013
For fast propagation of action potentials in the nervous system, higher vertebrates have developed a specialized plasma membrane structure, the myelin, ensheathing nerve fibers. Myelin sheaths are formed by Schwann cells in the peripheral nervous system (
Schmid, Daniela
core   +1 more source

Focus on 1,25-Dihydroxyvitamin D3 in the Peripheral Nervous System

Frontiers in Neuroscience, 2019
In this review, we draw attention to the roles of calcitriol (1,25-dihydroxyvitamin D3) in the trophicity of the peripheral nervous system. Calcitriol has long been known to be crucial in phosphocalcium homeostasis. However, recent discoveries concerning
Pierre Antoine Faye, Pierre Antoine Faye, François Poumeaud, Federica Miressi, Anne Sophie Lia, Anne Sophie Lia, Claire Demiot, Laurent Magy, Frédéric Favreau, Frédéric Favreau, Franck G. Sturtz, Franck G. Sturtz   +11 more
doaj   +1 more source