The Human Myelin Proteome and Sub-Metalloproteome Interaction Map: Relevance to Myelin-Related Neurological Diseases [PDF]
Brain Sciences, 2022 Myelin in humans is composed of about 80% lipids and 20% protein. Initially, myelin protein composition was considered low, but various recent proteome analyses have identified additional myelin proteins.
Christos T. Chasapis +4 more
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Myelin lipid metabolism and its role in myelination and myelin maintenance
The Innovation, 2023 Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high abundance of membrane lipids is one of myelin’s salient features that contribute to its unique role as an insulator that electrically isolates nerve fibers across ...
Joseph A. Barnes-Vélez +2 more
doaj +3 more sources
Experimental Neurology, 2016 Andreas Vesalius is attributed the discovery of white matter in the 16th century but van Leeuwenhoek is arguably the first to have observed myelinated fibers in 1717.
Boullerne AI (7930103)
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Myelin basic protein peptide 45–89 induces the release of nitric oxide from microglial cells. [PDF]
, 2002 Continuous (24 h) exposure of mixed oligodendrocyte/microglial cells to peptides 45–89 derived from citrullinated C8 isoforms of myelin basic protein (MBP) induces cell death.
Pichkhadze, B. +4 more
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Current Biology, 2016 Myelin is a key evolutionary acquisition that underlay the development of the large, complex nervous systems of all hinged-jaw vertebrates. By promoting rapid, efficient nerve conduction, myelination also made possible the development of the large body size of these vertebrates.
Salzer, J.L., Zalc, B.
openaire +3 more sources
Shaping Membrane Interfaces in Lipid Vesicles Mimicking the Cytoplasmic Leaflet of Myelin through Variation of Cholesterol and Myelin Basic Protein Contents [PDF]
, 2022 Myelin basic protein (MBP) is an intrinsically disordered protein and in the central nervous system (CNS) mainly responsible for connecting the cytoplasmic surfaces of the multilamellar, compact myelin.
Annette, Meister +4 more
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A Nanoscale Model System for the Human Myelin Sheath [PDF]
, 2021 Here, we for the first time establish nanodiscs with the challenging lipid composition of myelin of the peripheral or central nervous systems, respectively (PNS and CNS, both containing >40% cholesterol, which so far has been thought to be detrimental ...
David, Haselberger +11 more
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Is Myelin Repair Possible? [PDF]
, 2022 In the body, myelin is the coating over the axons, the “wires'' carrying our body’s signals. The insulator around the wires acts the same way myelin acts as an insulator in the brain. The signals in the neurons of people diagnosed with multiple sclerosis
Polidoro, Madison +5 more
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Differential expression and MAL-dependent targeting of the L-MAG and S-MAG isoforms to myelin membranes [PDF]
, 2003 Many degenerative diseases of the nervous system, including Multiple Sclerosis and peripheral neuropathies, are triggered by an impaired interaction between the axons and their surrounding myelin sheaths.
Erb, Michael
core +1 more source
Functional role of the overexpression of the myelin and lymphocyte protein MAL in Schwann cells [PDF]
, 2013 For fast propagation of action potentials in the nervous system, higher vertebrates have developed a specialized plasma membrane structure, the myelin, ensheathing nerve fibers. Myelin sheaths are formed by Schwann cells in the peripheral nervous system (
Schmid, Daniela
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