Results 21 to 30 of about 170,216 (297)
Particular aspects of myelin-axon interactions in health and disease : the expression of myelin-associated glycoprotein isoforms in CNS and PNS. Early axonal pathology in the dysmyelinating peripheral neuropathy CMT1A [PDF]
, 2007 An intact myelin sheath is crucial for the rapid propagation of action potentials along myelinated axons. There are many neurodegenerative diseases associated with defect myelin sheaths resulting in severe clinical symptoms such as multiple sclerosis ...
Flück, Bettina
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An organized 3D in vitro model for peripheral nerve studies [PDF]
, 2013 Three-dimensional cell cultures have been proposed to address the limitations in two-dimensional cell cultures (i.e. lack of relevant architectural features) and very few have developed 3D cell culture methods for peripheral nerve studies. Therefore, the
Daud, Muhammad Fauzi
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Orphanet Journal of Rare Diseases, 2019 Background Ribonucleases (RNases) are crucial for degradation of ribosomal RNA (rRNA). RNASET2 as a subtype of RNASEs is a 256 amino acid protein, encoded by RNASET2 gene located on chromosome six.
Reyhaneh Kameli +9 more
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EMBO Molecular Medicine, 2019 Current treatments in multiple sclerosis (MS) are modulating the inflammatory component of the disease, but no drugs are currently available to repair lesions.
Fabien Binamé +12 more
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Polarization and Myelination in Myelinating Glia [PDF]
ISRN Neurology, 2012 Myelinating glia, oligodendrocytes in central nervous system and Schwann cells in peripheral nervous system, form myelin sheath, a multilayered membrane system around axons enabling salutatory nerve impulse conduction and maintaining axonal integrity.
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Journal of Cell Science, 2014 ABSTRACTThe myelin sheath is a plasma membrane extension that is laid down in regularly spaced segments along axons of the nervous system. This process involves extensive changes in oligodendrocyte cell shape and membrane architecture. In this Cell Science at a Glance article and accompanying poster, we provide a model of how myelin of the central ...
Snaidero, Nicolas, Simons, Mikael
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Shaping Membrane Interfaces in Lipid Vesicles Mimicking the Cytoplasmic Leaflet of Myelin through Variation of Cholesterol and Myelin Basic Protein Contents [PDF]
, 2022 Myelin basic protein (MBP) is an intrinsically disordered protein and in the central nervous system (CNS) mainly responsible for connecting the cytoplasmic surfaces of the multilamellar, compact myelin.
Annette, Meister +4 more
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Bilateral horizontal gaze palsy in an 8‐year‐old girl: A rare case with NDUFS4 gene mutation
Clinical Case Reports, 2021 We report a patient with complex clinical presentation including multiple neurological symptoms and eye involvement. Upon genetic investigation, the patient was found to carry a novel homozygous mutation in the NDUFS4 gene, thus adding to the ...
Mohammad Vafaee‐Shahi +6 more
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Is Myelin a Mitochondrion? [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2012 It has been hypothesized that myelin acts like a mitochondrion, generating ATP across the membranes of its sheath. By calculating the proton motive force across the myelin membrane based on known values for the pH and membrane potential of the oligodendrocyte, we find that insufficient energy could be harvested from proton flow across the myelin ...
Harris, Julia J, Attwell, David
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Myelin activates FAK/Akt/NF-kappaB pathways and provokes CR3-dependent inflammatory response in murine system. [PDF]
PLoS ONE, 2010 Inflammatory response following central nervous system (CNS) injury contributes to progressive neuropathology and reduction in functional recovery. Axons are sensitive to mechanical injury and toxic inflammatory mediators, which may lead to demyelination.
Xin Sun +11 more
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