Results 21 to 30 of about 128,613 (264)

Emerging evidence for compromised axonal bioenergetics and axoglial metabolic coupling as drivers of neurodegeneration

Neurobiology of Disease, 2022
Impaired bioenergetic capacity of the nervous system is thought to contribute to the pathogenesis of many neurodegenerative diseases (NDD). Since neuronal synapses are believed to be the major energy consumers in the nervous system, synaptic derangements
Bogdan Beirowski
doaj   +1 more source

Myelin-Associated Glycoprotein Is a Myelin Signal that Modulates the Caliber of Myelinated Axons [PDF]

The Journal of Neuroscience, 1998
Myelination increases neuronal conduction velocity through its insulating properties and an unidentified extrinsic effect that increases axonal caliber. Although it is well established that demyelination can cause axonal atrophy, the myelin molecule that regulates axonal caliber is not known.
X, Yin, T O, Crawford, J W, Griffin, P h, Tu, V M, Lee, C, Li, J, Roder, B D, Trapp   +7 more
openaire   +2 more sources

Polyphosphoinositides in myelin [PDF]

Biochemical Journal, 1965
1. On fractionation of guinea-pig forebrain homogenates by differential and gradient-density centrifugation most of the polyphosphoinositides were recovered in the myelin-rich particles. 2. The phospholipids of pure preparations of myelin contained di- and tri-phosphoinositide in proportions 2-3 times greater than in the whole-brain phospholipids.
J, Eichberg, R M, Dawson
openaire   +2 more sources

Clinical presentation and outcome in infantile Sandhoff disease: a case series of 25 patients from Iranian neurometabolic bioregistry with five novel mutations

Orphanet Journal of Rare Diseases, 2018
Background Infantile Sandhoff disease (ISD) is a GM2 gangliosidosis that is classified as a lysosomal storage disorder. The most common symptoms of affected individuals at presentation are neurologic involvement.
Ali Reza Tavasoli, Nima Parvaneh, Mahmoud Reza Ashrafi, Zahra Rezaei, Johannes Zschocke, Parastoo Rostami   +5 more
doaj   +1 more source

Myelin Peptide–Mannan Conjugate Multiple Sclerosis Vaccines: Conjugation Efficacy and Stability of Vaccine Ingredient

Vaccines, 2021
Myelin peptide–mannan conjugates have been shown to be potential vaccines in the immunotherapy of multiple sclerosis. The conjugates are comprised from the epitope peptide and the polysaccharide mannan which transfers as a carrier the antigenic peptide ...
John Matsoukas, George Deraos, Kostas Kelaidonis, Md Kamal Hossain, Jack Feehan, Andreas G. Tzakos, Elizabeth Matsoukas, Emmanuel Topoglidis, Vasso Apostolopoulos   +8 more
doaj   +1 more source

The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay

Frontiers in Cellular Neuroscience, 2020
Myelin membranes are dominated by lipids while the complexity of their protein composition has long been considered to be low. However, numerous additional myelin proteins have been identified since.
Olaf Jahn, Sophie B. Siems, Kathrin Kusch, Dörte Hesse, Ramona B. Jung, Thomas Liepold, Marina Uecker, Ting Sun, Hauke B. Werner   +8 more
doaj   +1 more source

Protein kinase C epsilon activation regulates proliferation, migration, and epithelial to mesenchymal-like transition in rat Schwann cells

Frontiers in Cellular Neuroscience, 2023
IntroductionProtein kinase type C-ε (PKCε) plays an important role in the sensitization of primary afferent nociceptors, promoting mechanical hyperalgesia. In accordance, we showed that PKCε is present in sensory neurons of the peripheral nervous system (
Tasnim Mohamed, Alessandra Colciago, Marina Montagnani Marelli, Roberta Manuela Moretti, Valerio Magnaghi   +4 more
doaj   +1 more source

Pathological Insights From Quantitative Susceptibility Mapping and Diffusion Tensor Imaging in Ice Hockey Players Pre and Post-concussion

Frontiers in Neurology, 2018
Myelin sensitive MRI techniques, such as diffusion tensor imaging and myelin water imaging, have previously been used to reveal changes in myelin after sports-related concussions.
Alexander M. Weber, Alexander M. Weber, Anna Pukropski, Christian Kames, Christian Kames, Michael Jarrett, Michael Jarrett, Shiroy Dadachanji, Jack Taunton, David K. B. Li, David K. B. Li, David K. B. Li, Alexander Rauscher, Alexander Rauscher, Alexander Rauscher   +14 more
doaj   +1 more source

Occurrence of Extramedullary Relapses in Pediatric Acute Lymphoblastic Leukemia After Treatment With Blinatumomab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We report a retrospective single‐center analysis of pediatric patients with relapsed or refractory B‐cell precursor acute lymphoblastic leukemia focusing on relapses outside of the typical locations, bone marrow, central nervous system, or testes.
Johanna Kunz, Martin Ebinger, Michaela Döring, Markus Mezger, Ursula Holzer, Rupert Handgretinger, Peter Lang, Manon Queudeville   +7 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source