Results 1 to 10 of about 62,903 (117)

Targeting enhancing myelin regeneration reverses cognitive deficits in a mouse model of intellectual disability [PDF]

Neurotherapeutics
The early postnatal period is a critical window for brain maturation, during which oligodendrogenesis, myelination, and synaptogenesis are dynamically orchestrated to support cognitive development.
Pingping Qiao, He Wang, Pingping Qu, Lifang Guo, Yanbo Zhou, Tingting Zeng, Jiang Chen, Jian Li, Yimin Hu, Guiquan Chen   +9 more
doaj   +2 more sources

Histone demethylase KDM6B promotes postnatal oligodendrocyte maturation and cortical myelination [PDF]

Frontiers in Cellular Neuroscience
IntroductionPostnatal cortical myelination requires epigenetic activation of oligodendrocyte gene programs, but the role of histone demethylases in vivo remains unclear.MethodsWe conditionally deleted Kdm6b in Emx1+ dorsal telencephalic progenitors and ...
Ruth Lambries, Zihan Shen, George I. Mias, George I. Mias, Jin He   +4 more
doaj   +2 more sources

A Glance at the Molecules That Regulate Oligodendrocyte Myelination

Current Issues in Molecular Biology, 2022
Oligodendrocyte (OL) myelination is a critical process for the neuronal axon function in the central nervous system. After demyelination occurs because of pathophysiology, remyelination makes repairs similar to myelination.
Shunqi Wang, Suqi Zou, Wang Shunqi
exaly   +3 more sources

Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis

Cell Reports, 2023
Summary: How neuronal signaling affects brain myelination remains poorly understood. We show dysregulated neuronal RHEB-mTORC1-DLK1 axis impairs brain myelination.
Haijiao Huang, Bo Jing, Feiyan Zhu, Wanxiang Jiang, Ping Tang, Liyang Shi, Huiting Chen, Guoru Ren, Shiyao Xia, Luoling Wang, Yiyuan Cui, Zhiwen Yang, Alexander J. Platero, Andrew P. Hutchins, Mina Chen, Paul F. Worley, Bo Xiao   +16 more
doaj   +1 more source

In vitro myelination using explant culture of dorsal root ganglia: An efficient tool for analyzing peripheral nerve differentiation and disease modeling.

PLoS ONE, 2023
Peripheral nerves conducting motor and somatosensory signals in vertebrate consist of myelinated and unmyelinated axons. In vitro myelination culture, generated by co-culturing Schwann cells (SCs) and dorsal root ganglion (DRG) neurons, is an ...
Yurika Numata-Uematasu, Shuji Wakatsuki, Yuka Kobayashi-Ujiie, Kazuhisa Sakai, Noritaka Ichinohe, Toshiyuki Araki   +5 more
doaj   +1 more source

Regional Difference in Myelination in Monocarboxylate Transporter 8 Deficiency: Case Reports and Literature Review of Cases in Japan

Frontiers in Neurology, 2021
Background: Monocarboxylate transporter 8 (MCT8) is a thyroid hormone transmembrane transporter protein. MCT8 deficiency induces severe X-linked psychomotor retardation. Previous reports have documented delayed myelination in the central white matter (WM)
Hideyuki Iwayama, Tatsushi Tanaka, Kohei Aoyama, Masaharu Moroto, Shinsuke Adachi, Shinsuke Adachi, Yasuko Fujisawa, Hiroki Matsuura, Kyoko Takano, Haruo Mizuno, Akihisa Okumura   +10 more
doaj   +1 more source

Myelination of parvalbumin interneurons shapes the function of cortical sensory inhibitory circuits

Nature Communications, 2020
Myelination optimizes conduction speed of excitatory neurons. However, whether myelination of interneurons (INs) refines cortical networks is unclear.
Najate Benamer, Marie Vidal, Maddalena Balia, María Cecilia Angulo   +3 more
doaj   +1 more source

C1q is essential for myelination in the central nervous system (CNS)

iScience, 2023
Summary: Myelin sheath in the central nervous system (CNS) is essential for efficient action potential conduction. Microglia, the macrophages in the CNS, are suggested to regulate myelin development.
Qiang Yu, Nan Zhang, Teng Guan, Ying Guo, Hassan Marzban, Benjamin Lindsey, Jiming Kong   +6 more
doaj   +1 more source

Motor Learning and Physical Exercise in Adaptive Myelination and Remyelination

ASN Neuro, 2022
The idea that myelination is driven by both intrinsic and extrinsic cues has gained much traction in recent years. Studies have demonstrated that myelination occurs in an intrinsic manner during early development and continues through adulthood in an ...
Mara S. Bloom, Jennifer Orthmann-Murphy, Judith B. Grinspan   +2 more
doaj   +1 more source

Glial Cells Promote Myelin Formation and Elimination

Frontiers in Cell and Developmental Biology, 2021
Building a functional nervous system requires the coordinated actions of many glial cells. In the vertebrate central nervous system (CNS), oligodendrocytes myelinate neuronal axons to increase conduction velocity and provide trophic support.
Alexandria N. Hughes
doaj   +1 more source