Results 11 to 20 of about 79,170 (253)

A Glance at the Molecules That Regulate Oligodendrocyte Myelination

Current Issues in Molecular Biology, 2022
Oligodendrocyte (OL) myelination is a critical process for the neuronal axon function in the central nervous system. After demyelination occurs because of pathophysiology, remyelination makes repairs similar to myelination.
Shunqi Wang, Suqi Zou
exaly   +4 more sources

Prolonged Environmental Enrichment Promotes Developmental Myelination [PDF]

Frontiers in Cell and Developmental Biology, 2021
Postnatal neurodevelopment is profoundly influenced by environmental experiences. Environmental enrichment is a commonly used experimental paradigm that has uncovered numerous examples of experience-dependent plasticity in health and disease.
Evan Z. Goldstein, Vera Pertsovskaya, Thomas A. Forbes, Jeffrey L. Dupree, Vittorio Gallo   +4 more
doaj   +2 more sources

The shifting landscape of brain-wide myelination across the human lifespan [PDF]

Nature Communications
Despite the central role of myelination in brain function and plasticity, its characterization remains fragmented, with existing studies typically constrained either spatially, by focusing on selected brain structures, or temporally, by covering only ...
Sahar Ahmad, Khoi Minh Huynh, Guoye Lin, Pew-Thian Yap   +3 more
doaj   +2 more sources

Data supporting the role of Fyn in initiating myelination in the peripheral nervous system

Data in Brief, 2016
Transgenic mice, which express active Fyn tyrosine kinase under the control of a glial fibrillary acidic protein promoter, have been produced. This promoter induces protein expression in the initiation stage of myelination in the peripheral nervous ...
Yuki Miyamoto, Moe Tamano, Tomohiro Torii, Kazuko Kawahara, Kazuaki Nakamura, Akito Tanoue, Shuji Takada, Junji Yamauchi   +7 more
doaj   +2 more sources

Data on the effect of knockout of cytohesin-1 in myelination-related protein kinase signaling

Data in Brief, 2017
Cytohesin-1 is the guanine-nucleotide exchange factor of Arf6, a small GTPase of Arf family, and participates in cellular morphological changes. Knockout mice of cytohesin-1 exhibit decreased myelination of neuronal axons in the peripheral nervous system
Ruri Tsuneishi, Naoto Matsumoto, Misa Itaoka, Yuri Urai, Minami Kaneko, Natsumi Watanabe, Shou Takashima, Yoichi Seki, Takako Morimoto, Hiroyuki Sakagami, Yuki Miyamoto, Junji Yamauchi   +11 more
doaj   +2 more sources

Motor Learning and Physical Exercise in Adaptive Myelination and Remyelination

ASN Neuro, 2022
The idea that myelination is driven by both intrinsic and extrinsic cues has gained much traction in recent years. Studies have demonstrated that myelination occurs in an intrinsic manner during early development and continues through adulthood in an ...
Jennifer L Orthmann-Murphy, Judith B Grinspan   +1 more
exaly   +2 more sources

Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis

Cell Reports, 2023
Summary: How neuronal signaling affects brain myelination remains poorly understood. We show dysregulated neuronal RHEB-mTORC1-DLK1 axis impairs brain myelination.
Haijiao Huang, Bo Jing, Feiyan Zhu, Wanxiang Jiang, Ping Tang, Liyang Shi, Huiting Chen, Guoru Ren, Shiyao Xia, Luoling Wang, Yiyuan Cui, Zhiwen Yang, Alexander J. Platero, Andrew P. Hutchins, Mina Chen, Paul F. Worley, Bo Xiao   +16 more
doaj   +2 more sources

Social Experience-Dependent Myelination: An Implication for Psychiatric Disorders [PDF]

Neural Plasticity, 2015
Myelination is one of the strategies to promote the conduction velocity of axons in order to adjust to evolving environment in vertebrates. It has been shown that myelin formation depends on genetic programing and experience, including multiple factors ...
Michihiro Toritsuka, Manabu Makinodan, Toshifumi Kishimoto   +2 more
doaj   +2 more sources

CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair

Nature Communications, 2020
Myelination by Schwann cells (SC) in the peripheral nervous system is essential for motor function, and dysregulation of SC myelination can lead to various neuropathies.
Jincheng Wang, Jiajia Wang, Lijun Yang, Chuntao Zhao, Laiman Natalie Wu, Lingli Xu, Feng Zhang, Qinjie Weng, Michael Wegner, Q. Richard Lu   +9 more
doaj   +2 more sources

Initiation of CNS Myelination in the Optic Nerve Is Dependent on Axon Caliber [PDF]

Cell Reports, 2018
Summary: Emerging evidence suggests that neuronal signaling is important for oligodendrocyte myelination; however, the necessity of this signaling during development is unclear.
Sonia R. Mayoral, Ainhoa Etxeberria, Yun-An A. Shen, Jonah R. Chan   +3 more
doaj   +2 more sources