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Myelination [PDF]

open access: yesCurrent Biology, 2016
Myelin is a key evolutionary acquisition that underlay the development of the large, complex nervous systems of all hinged-jaw vertebrates. By promoting rapid, efficient nerve conduction, myelination also made possible the development of the large body size of these vertebrates.
Salzer, J.L., Zalc, B.
openaire   +4 more sources

Bihemispheric alterations in myelination in children following unilateral perinatal stroke

open access: yesNeuroImage: Clinical, 2018
Background: Stroke is a leading cause of perinatal brain injury with variable outcomes including cerebral palsy and epilepsy. The biological processes that underlie these heterogeneous outcomes are poorly understood.
Sabrina Yu   +7 more
doaj   +2 more sources

Neuron–Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells

open access: yesLife, 2021
Axonal myelination by oligodendrocytes increases the speed and reliability of action potential propagation, and so plays a pivotal role in cortical information processing.
Elisa Mazuir   +2 more
doaj   +2 more sources

The dual role of astrocytes in myelination [PDF]

open access: yes, 2010
Astrocytes are the most abundant cell within the central nervous system (CNS) and yet despite this, the true extent of their role in health and disease has not been fully elucidated.
Nash, Besma
core   +7 more sources

Overview of myelin, major myelin lipids, and myelin-associated proteins

open access: yesFrontiers in Chemistry, 2023
Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains the main characteristics of biological membranes, such as lipid bilayer, but differs from them in several important respects. In this review, we focus on aspects of myelin composition that are peculiar to this structure and differentiate it from the more ...
Alexander Kister, Ilya Kister
openaire   +3 more sources

Myelin lipid metabolism and its role in myelination and myelin maintenance

open access: yesThe Innovation, 2023
Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high abundance of membrane lipids is one of myelin's salient features that contribute to its unique role as an insulator that electrically isolates nerve fibers across their myelinated surface.
Joseph A. Barnes-Vélez   +2 more
openaire   +3 more sources

Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo [PDF]

open access: yes, 2012
<b>Background</b> Myelination is an exquisite and dynamic example of heterologous cell-cell interaction, which consists of the concentric wrapping of multiple layers of oligodendrocyte membrane around neuronal axons.
Strachan, D.   +19 more
core   +1 more source

Functional role of the overexpression of the myelin and lymphocyte protein MAL in Schwann cells [PDF]

open access: yes, 2013
For fast propagation of action potentials in the nervous system, higher vertebrates have developed a specialized plasma membrane structure, the myelin, ensheathing nerve fibers. Myelin sheaths are formed by Schwann cells in the peripheral nervous system (
Schmid, Daniela
core   +1 more source

The development of a ε-polycaprolactone (PCL) scaffold for CNS repair [PDF]

open access: yes, 2013
Potential treatment strategies for the repair of spinal cord injury (SCI) currently favour a combinatorial approach incorporating several factors, including exogenous cell transplantation and biocompatible scaffolds. The use of scaffolds for bridging the
Boomkamp, S.D.   +13 more
core   +1 more source

Neuron to Oligodendrocyte Precursor Cell Synapses: Protagonists in Oligodendrocyte Development and Myelination, and Targets for Therapeutics

open access: yesFrontiers in Neuroscience, 2022
The development of neuronal circuitry required for cognition, complex motor behaviors, and sensory integration requires myelination. The role of glial cells such as astrocytes and microglia in shaping synapses and circuits have been covered in other ...
Daniela M. S. Moura   +4 more
doaj   +1 more source

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