Frontiers in Neuroscience, 2022 The development of neuronal circuitry required for cognition, complex motor behaviors, and sensory integration requires myelination. The role of glial cells such as astrocytes and microglia in shaping synapses and circuits have been covered in other ...
Daniela M. S. Moura +4 more
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TACE/ADAM17 Is Essential for Oligodendrocyte Development and CNS Myelination [PDF]
, 2014 Several studies have elucidated the significance of a disintegrin and metalloproteinase proteins (ADAMs) in PNS myelination, but there is no evidence if they also play a role in oligodendrogenesis and CNS myelination.
Aguirre, Adan +6 more
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Neurotoxic Reactive Astrocytes Drive Defective Myelination in Acute Perinatal White Matter Injury. [PDF]
, 2022 Introduction: Acute perinatal white matter injury (apWMI) is the most common form of brain injury in preterm infants, yet the mechanisms underlying neurologic dysmaturation in this disease are far from understood.
Renz, Patricia +6 more
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Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
eLife, 2017 Myelination is a biosynthetically demanding process in which mTORC1, the gatekeeper of anabolism, occupies a privileged regulatory position. We have shown previously that loss of mTORC1 function in Schwann cells (SCs) hampers myelination.
Gianluca Figlia +4 more
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Biological role of dystroglycan in Schwann cell function and its implications in peripheral nervous system diseases [PDF]
, 2010 Dystroglycan is a central component of the dystrophin-glycoprotein complex (DGC) that links extracellular matrix with cytoskeleton, expressed in a variety of fetal and adult tissues.
Kiichiro Matsumura +3 more
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Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination [PDF]
, 2016 Myelination occurs selectively around neuronal axons to increase the efficiency and velocity of action potentials. While oligodendrocytes are capable of myelinating permissive structures in the absence of molecular cues, structurally permissive neuronal ...
Leshkowitz, Dena +10 more
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Functional phylogenetic analysis of LGI proteins identifies an interaction motif crucial for myelination [PDF]
, 2014 The cellular interactions that drive the formation and maintenance of the insulating myelin sheath around axons are only partially understood. Leucine-rich glioma-inactivated (LGI) proteins play important roles in nervous system development and mutations
Leslie, K. +8 more
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Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.
PLoS Biology, 2013 Myelination is essential for rapid impulse conduction in the CNS, but what determines whether an individual axon becomes myelinated remains unknown. Here we show, using a myelinating coculture system, that there are two distinct modes of myelination, one
Iben Lundgaard +11 more
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Complement factor B is essential for the proper function of the peripheral auditory system
Frontiers in Neurology, 2023 Sensorineural hearing loss is associated with dysfunction of cochlear cells. Although immune cells play a critical role in maintaining the inner ear microenvironment, the precise immune-related molecular mechanisms underlying the pathophysiology of ...
LaShardai N. Brown +6 more
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Is Myelin a Mitochondrion? [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2012 It has been hypothesized that myelin acts like a mitochondrion, generating ATP across the membranes of its sheath. By calculating the proton motive force across the myelin membrane based on known values for the pH and membrane potential of the oligodendrocyte, we find that insufficient energy could be harvested from proton flow across the myelin ...
Harris, Julia J, Attwell, David
openaire +2 more sources