Results 21 to 30 of about 72,448 (306)
Frontiers in Neuroscience, 2022 The development of neuronal circuitry required for cognition, complex motor behaviors, and sensory integration requires myelination. The role of glial cells such as astrocytes and microglia in shaping synapses and circuits have been covered in other ...
Daniela M. S. Moura +4 more
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Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
eLife, 2017 Myelination is a biosynthetically demanding process in which mTORC1, the gatekeeper of anabolism, occupies a privileged regulatory position. We have shown previously that loss of mTORC1 function in Schwann cells (SCs) hampers myelination.
Gianluca Figlia +4 more
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Biological role of dystroglycan in Schwann cell function and its implications in peripheral nervous system diseases [PDF]
, 2010 Dystroglycan is a central component of the dystrophin-glycoprotein complex (DGC) that links extracellular matrix with cytoskeleton, expressed in a variety of fetal and adult tissues.
Kiichiro Matsumura +3 more
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Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination [PDF]
, 2016 Myelination occurs selectively around neuronal axons to increase the efficiency and velocity of action potentials. While oligodendrocytes are capable of myelinating permissive structures in the absence of molecular cues, structurally permissive neuronal ...
Leshkowitz, Dena +10 more
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Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.
PLoS Biology, 2013 Myelination is essential for rapid impulse conduction in the CNS, but what determines whether an individual axon becomes myelinated remains unknown. Here we show, using a myelinating coculture system, that there are two distinct modes of myelination, one
Iben Lundgaard +11 more
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Complement factor B is essential for the proper function of the peripheral auditory system
Frontiers in Neurology, 2023 Sensorineural hearing loss is associated with dysfunction of cochlear cells. Although immune cells play a critical role in maintaining the inner ear microenvironment, the precise immune-related molecular mechanisms underlying the pathophysiology of ...
LaShardai N. Brown +6 more
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Is Myelin a Mitochondrion? [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2012 It has been hypothesized that myelin acts like a mitochondrion, generating ATP across the membranes of its sheath. By calculating the proton motive force across the myelin membrane based on known values for the pH and membrane potential of the oligodendrocyte, we find that insufficient energy could be harvested from proton flow across the myelin ...
Harris, Julia J, Attwell, David
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eLife, 2019 GABAergic fast-spiking parvalbumin-positive (PV) interneurons are frequently myelinated in the cerebral cortex. However, the factors governing the topography of cortical interneuron myelination remain incompletely understood.
Jeffrey Stedehouder +10 more
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, 2019 There is now increasing evidence that myelin is not only generated early in development, but also during adulthood possibly contributing to lifelong plasticity of the brain.
Simons, Mikael +3 more
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Data supporting the role of Fyn in initiating myelination in the peripheral nervous system
Data in Brief, 2016 Transgenic mice, which express active Fyn tyrosine kinase under the control of a glial fibrillary acidic protein promoter, have been produced. This promoter induces protein expression in the initiation stage of myelination in the peripheral nervous ...
Yuki Miyamoto +7 more
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