Results 31 to 40 of about 72,448 (306)

Polarization and Myelination in Myelinating Glia [PDF]

open access: yesISRN Neurology, 2012
Myelinating glia, oligodendrocytes in central nervous system and Schwann cells in peripheral nervous system, form myelin sheath, a multilayered membrane system around axons enabling salutatory nerve impulse conduction and maintaining axonal integrity.
openaire   +2 more sources

Data on the effect of knockout of cytohesin-1 in myelination-related protein kinase signaling

open access: yesData in Brief, 2017
Cytohesin-1 is the guanine-nucleotide exchange factor of Arf6, a small GTPase of Arf family, and participates in cellular morphological changes. Knockout mice of cytohesin-1 exhibit decreased myelination of neuronal axons in the peripheral nervous system
Ruri Tsuneishi   +11 more
doaj   +1 more source

Clemastine promotes oligodendrocyte precursor cell differentiation and myelination after acute radiation injury

open access: yesFushe yanjiu yu fushe gongyi xuebao, 2021
A rat radiation injury model was constructed, in which myelin basic protein (MBP) expression was detected via western blot. Primary oligodendrocyte precursor cells (OPCs) and neuronal cells were isolated from Sprague-Dawley rats, and expression of ...
WANG Yanyan   +5 more
doaj   +1 more source

Assessment of normal myelination in infants and young children using the T1w/T2w mapping technique

open access: yesFrontiers in Neuroscience, 2023
BackgroundWhite matter myelination is a crucial process of CNS maturation. The purpose of this study was to validate the T1w/T2w mapping technique for brain myelination assessment in infants and young children.MethodsNinety-four patients (0–23 months of ...
Elena Filimonova   +9 more
doaj   +1 more source

Human Schwann Cell Transplantation for Spinal Cord Injury: Prospects and Challenges in Translational Medicine

open access: yesFrontiers in Cellular Neuroscience, 2021
The benefits of transplanting cultured Schwann cells (SCs) for the treatment of spinal cord injury (SCI) have been systematically investigated in experimental animals since the early 1990s. Importantly, human SC (hSC) transplantation for SCI has advanced
Paula V. Monje   +5 more
doaj   +1 more source

Polyphosphoinositides in myelin [PDF]

open access: yesBiochemical Journal, 1965
1. On fractionation of guinea-pig forebrain homogenates by differential and gradient-density centrifugation most of the polyphosphoinositides were recovered in the myelin-rich particles. 2. The phospholipids of pure preparations of myelin contained di- and tri-phosphoinositide in proportions 2-3 times greater than in the whole-brain phospholipids.
J, Eichberg, R M, Dawson
openaire   +2 more sources

CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair

open access: yesNature Communications, 2020
Myelination by Schwann cells (SC) in the peripheral nervous system is essential for motor function, and dysregulation of SC myelination can lead to various neuropathies.
Jincheng Wang   +9 more
doaj   +1 more source

Initiation of CNS Myelination in the Optic Nerve Is Dependent on Axon Caliber

open access: yesCell Reports, 2018
Summary: Emerging evidence suggests that neuronal signaling is important for oligodendrocyte myelination; however, the necessity of this signaling during development is unclear.
Sonia R. Mayoral   +3 more
doaj   +1 more source

TACE/ADAM17 Is Essential for Oligodendrocyte Development and CNS Myelination

open access: yes, 2014
Several studies have elucidated the significance of a disintegrin and metalloproteinase proteins (ADAMs) in PNS myelination, but there is no evidence if they also play a role in oligodendrogenesis and CNS myelination.
Aguirre, Adan   +6 more
core   +1 more source

Neurotoxic Reactive Astrocytes Drive Defective Myelination in Acute Perinatal White Matter Injury.

open access: yes, 2022
Introduction: Acute perinatal white matter injury (apWMI) is the most common form of brain injury in preterm infants, yet the mechanisms underlying neurologic dysmaturation in this disease are far from understood.
Renz, Patricia   +6 more
core   +1 more source

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