Results 31 to 40 of about 79,170 (253)

The development of a ε-polycaprolactone (PCL) scaffold for CNS repair [PDF]

, 2013
Potential treatment strategies for the repair of spinal cord injury (SCI) currently favour a combinatorial approach incorporating several factors, including exogenous cell transplantation and biocompatible scaffolds. The use of scaffolds for bridging the
Boomkamp, S.D., Rebecca Lamond (7128584), Donoghue, P.S., Lamond, R., Nikolaj Gadegaard (1292763), Riehle, M.O., Stephanie D. Boomkamp (7128587), Mathis O. Riehle (1292769), Tao, S., Barnett, S.C., Peter S. Donoghue (7128581), Tao Sun (1255119), Gadegaard, N., Susan C. Barnett (7128590)   +13 more
core   +1 more source

Neuron to Oligodendrocyte Precursor Cell Synapses: Protagonists in Oligodendrocyte Development and Myelination, and Targets for Therapeutics

Frontiers in Neuroscience, 2022
The development of neuronal circuitry required for cognition, complex motor behaviors, and sensory integration requires myelination. The role of glial cells such as astrocytes and microglia in shaping synapses and circuits have been covered in other ...
Daniela M. S. Moura, Emma J. Brennan, Robert Brock, Laura A. Cocas, Laura A. Cocas   +4 more
doaj   +1 more source

Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system

eLife, 2017
Myelination is a biosynthetically demanding process in which mTORC1, the gatekeeper of anabolism, occupies a privileged regulatory position. We have shown previously that loss of mTORC1 function in Schwann cells (SCs) hampers myelination.
Gianluca Figlia, Camilla Norrmén, Jorge A Pereira, Daniel Gerber, Ueli Suter   +4 more
doaj   +1 more source

Neuron–Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells

Life, 2021
Axonal myelination by oligodendrocytes increases the speed and reliability of action potential propagation, and so plays a pivotal role in cortical information processing.
Elisa Mazuir, Desdemona Fricker, Nathalie Sol-Foulon   +2 more
doaj   +1 more source

Biological role of dystroglycan in Schwann cell function and its implications in peripheral nervous system diseases [PDF]

, 2010
Dystroglycan is a central component of the dystrophin-glycoprotein complex (DGC) that links extracellular matrix with cytoskeleton, expressed in a variety of fetal and adult tissues.
Kiichiro Matsumura, Matsumura, Kiichiro, Masaki, Toshihiro, Toshihiro Masaki   +3 more
core   +1 more source

Kif13b Regulates PNS and CNS Myelination Through the Dlg1 Scaffold [PDF]

, 2016
Microtubule-based kinesin motors have many cellular functions, including the transport of a variety of cargos. However, unconventional roles have recently emerged, and kinesins have also been reported to act as scaffolding proteins and signaling ...
Bolino, A., Palmisano, Marilena, Palmisano, M., Sherman, Diane L., Brophy, P., Guerrero-Valero, M., Previtali, Stefano C, Huganir, R. L., Peter J. Brophy (3174942), Peter J Brophy, Bolino, Alessandra, Noseda, Roberta, Alessandra Bolino, Roberta Noseda, Cuenda, A., Nave, K., Valeria Alberizzi, Marilena Palmisano, Guerrero-Valero, Marta, Huganir, R., Richard L. Huganir (123343), Marta Guerrero-Valero (2234071), Huganir, Richard L., Brophy, Peter, Richard L Huganir, Alberizzi, Valeria, Alessandra Bolino (200578), Alberizzi, V., Sherman, Diane, Klaus-Armin Nave (267354), Nave, Klaus-Armin, Cuenda, Ana, Ana Cuenda (126376), Feltri, M., Noseda, R., Valeria Alberizzi (3174933), Maria Laura Feltri, Diane L. Sherman (3174930), Feltri, Maria Laura, Sherman, D., Stefano C. Previtali (332140), Previtali, Stefano C., Diane L Sherman, Maria Laura Feltri (3174936), Previtali, S., Stefano C Previtali, Klaus-Armin Nave, Marta Guerrero-Valero, Roberta Noseda (3174939), Barres, Ben A., Marilena Palmisano (591058), Ana Cuenda, Alberizzi V, Noseda R, Huganir RL, Cuenda A, Nave KA, Brophy, Peter J., Palmisano M, Guerrero Valero, Marta, Guerrero-Valero M, Previtali SC, Bolino A, Sherman DL, Brophy PJ, Feltri ML   +65 more
core   +1 more source

Complement factor B is essential for the proper function of the peripheral auditory system

Frontiers in Neurology, 2023
Sensorineural hearing loss is associated with dysfunction of cochlear cells. Although immune cells play a critical role in maintaining the inner ear microenvironment, the precise immune-related molecular mechanisms underlying the pathophysiology of ...
LaShardai N. Brown, Jeremy L. Barth, Shabih Jafri, Jeffrey A. Rumschlag, Tyreek R. Jenkins, Carl Atkinson, Hainan Lang   +6 more
doaj   +1 more source

Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination [PDF]

, 2016
Myelination occurs selectively around neuronal axons to increase the efficiency and velocity of action potentials. While oligodendrocytes are capable of myelinating permissive structures in the absence of molecular cues, structurally permissive neuronal ...
Leshkowitz, Dena, Lyons, David A., Shen, Yun-An A., Peles, Elior, Eshed-Eisenbach, Yael, Osso, Lindsay A., Kay, Jeremy N., Aurrand-Lions, Michel, Redmond, Stephanie A., Chan, Jonah R., Mei, Feng   +10 more
core   +1 more source

Grey matter myelination [PDF]

, 2019
There is now increasing evidence that myelin is not only generated early in development, but also during adulthood possibly contributing to lifelong plasticity of the brain.
Simons, Mikael, Sebastian Timmler, Mikael Simons, Timmler, Sebastian   +3 more
core   +1 more source

Clemastine promotes oligodendrocyte precursor cell differentiation and myelination after acute radiation injury

Fushe yanjiu yu fushe gongyi xuebao, 2021
A rat radiation injury model was constructed, in which myelin basic protein (MBP) expression was detected via western blot. Primary oligodendrocyte precursor cells (OPCs) and neuronal cells were isolated from Sprague-Dawley rats, and expression of ...
WANG Yanyan, CHANG Kai, LIU Chenxia, NA Wanlin, JIANG Zhongyong, XIONG Jie   +5 more
doaj   +1 more source