Results 61 to 70 of about 5,891 (192)

Cerebellar Cortical Demyelination in the Murine Cuprizone Model

Brain Pathology, 2010
AbstractIn multiple sclerosis, demyelination occurs beside the white‐matter structures and in the cerebral and cerebellar cortex. We have previously shown that, in the cuprizone model, demyelination is present not only in the corpus callosum but also in the cerebral cortex.
Thomas, Skripuletz, Jens-Heiko, Bussmann, Viktoria, Gudi, Paraskevi N, Koutsoudaki, Refik, Pul, Darius, Moharregh-Khiabani, Maren, Lindner, Martin, Stangel   +7 more
openaire   +3 more sources

Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance

Molecular Neurodegeneration, 2022
Background Microglia regulate the response to injury and disease in the brain and spinal cord. In white matter diseases microglia may cause demyelination. However, how microglia respond and regulate demyelination is not fully understood.
Sameera Zia, Brady P. Hammond, Martin Zirngibl, Anastasia Sizov, Charbel S. Baaklini, Sharmistha P. Panda, Madelene F. S. Ho, Kelly V. Lee, Apurba Mainali, Mena K. Burr, Sioned Williams, Andrew V. Caprariello, Christopher Power, Thomas Simmen, Bradley J. Kerr, Jason R. Plemel   +15 more
doaj   +1 more source

APP/Aβ Signaling Orchestrates Reactive Astrocyte Networks in Alzheimer's Disease

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Stress increases astrocyte APP production, generating amyloid‐β (Aβ). Aβ then diffuses to neighboring astrocytes, stimulating further APP and Aβ production and creating a self‐reinforcing cycle. Over time, impaired Aβ clearance leads to its accumulation, chronic inflammation, and contributes to sporadic Alzheimer's disease. ABSTRACT Alzheimer's disease
Gretsen Velezmoro Jauregui, Sophie Coomes, Elizabeth Emmett, Alex Thatcher, Nicole Oyelakin, Maria Čarna, Jana Zelinkova, Jan Sebastian Novotny, Natalie Polakova, Tarun Kuruvilla, Robert Zorec, Alexei Verkhratsky, Vladimir Parpura, David Morgan, Kenneth L. Moya, Clara Limback‐Stokin, Gorazd Bernard Stokin   +16 more
wiley   +1 more source

Deep gray matter demyelination detected by magnetization transfer ratio in the cuprizone model. [PDF]

PLoS ONE, 2013
In multiple sclerosis (MS), the correlation between lesion load on conventional magnetic resonance imaging (MRI) and clinical disability is weak. This clinico-radiological paradox might partly be due to the low sensitivity of conventional MRI to detect ...
Sveinung Fjær, Lars Bø, Arvid Lundervold, Kjell-Morten Myhr, Tina Pavlin, Oivind Torkildsen, Stig Wergeland   +6 more
doaj   +1 more source

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, Volume 111, Issue 7, Page 3179-3190, 1 July 2026.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source

Astrocytes: Lessons Learned from the Cuprizone Model

International Journal of Molecular Sciences, 2023
A diverse array of neurological and psychiatric disorders, including multiple sclerosis, Alzheimer’s disease, and schizophrenia, exhibit distinct myelin abnormalities at both the molecular and histological levels. These aberrations are closely linked to dysfunction of oligodendrocytes and alterations in myelin structure, which may be pivotal factors ...
openaire   +2 more sources

Leucine Supplementation in Cuprizone-Induced Oligodendrocyte Toxicity [PDF]

, 2019
Cuprizone is a copper chelator that induces demyelination in the central nervous system when fed to mice. This compound is thought to target Complex IV and disrupt mitochondrial metabolism leading to loss of myelin-producing oligodendrocytes.
Ley, Michael
core   +1 more source

In toxic demyelination oligodendroglial cell death occurs early and is FAS independent

Neurobiology of Disease, 2010
Oligodendroglial cell death is a frequent phenomenon of many neurological diseases, e.g. in demyelinating diseases such as multiple sclerosis (MS). The underlying mechanisms are largely unknown.
Amke Hesse, Michael Wagner, Jasmin Held, Wolfgang Brück, Gabriela Salinas-Riester, Zhenyue Hao, Ari Waisman, Tanja Kuhlmann   +7 more
doaj   +1 more source

Experimental plan in the cuprizone experiment. [PDF]

, 2023
IntroductionMultiple sclerosis (MS) is characterized by chronic inflammation, demyelination, and axonal degeneration within the central nervous system (CNS), for which there is no current treatment available with the ability to promote neuroprotection or
Lars Bø (199928), Kamal Mustafa (495710), Christopher Elnan Kvistad (3140868), Samih Mohamed-Ahmed (5871182), Torbjørn Kråkenes (12696620), Stig Wergeland (199899), Daniela-Elana Costea (17364394), Niyaz Al-Sharabi (17364391), Siren Fromreide (9278171)   +8 more
core   +1 more source

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source