Results 61 to 70 of about 6,317 (193)
, 2023 The development of new neurotherapeutics depends on appropriate animal models being chosen in preclinical studies. The cuprizone model is an effective tool for studying demyelination and remyelination processes in the brain, but blood–brain barrier
Vladimir Chekhonin +10 more
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In toxic demyelination oligodendroglial cell death occurs early and is FAS independent
Neurobiology of Disease, 2010 Oligodendroglial cell death is a frequent phenomenon of many neurological diseases, e.g. in demyelinating diseases such as multiple sclerosis (MS). The underlying mechanisms are largely unknown.
Amke Hesse +7 more
doaj +1 more source
Acta Physiologica, Volume 242, Issue 9, September 2026.ABSTRACT In the central nervous system (CNS), the tissue microenvironment is continuously monitored and regulated to secure the unobstructed function of neurons and of their networks. This is a key function of the neurovascular niche (NVN), which is the interface between the cells of the nervous tissue and the cells and the content of blood vessels. It
Ilias Kazanis +4 more
wiley +1 more source
Astrocytes: Lessons Learned from the Cuprizone Model
International Journal of Molecular Sciences, 2023 A diverse array of neurological and psychiatric disorders, including multiple sclerosis, Alzheimer’s disease, and schizophrenia, exhibit distinct myelin abnormalities at both the molecular and histological levels. These aberrations are closely linked to dysfunction of oligodendrocytes and alterations in myelin structure, which may be pivotal factors ...
openaire +2 more sources
Neurotoxicity of Cuprizone in Female and Male Rats: Electrophysiological Observations
, 2018 Cuprizone induces massive demyelination in the CNS; however, the effects of cuprizone on the functions of the peripheral nervous system, as well as differential effects it may exert on males and females, have not yet been studied.
Ozcan, M., Unsal, C.
core +1 more source
High‐Resolution Diffusion Kurtosis Imaging of Hippocampus Subfields Across the Healthy Lifespan
NMR in Biomedicine, Volume 39, Issue 8, August 2026.Developmental and aging changes were examined in the hippocampus using 1 mm isotropic diffusion kurtosis imaging in 363 participants aged 5–90 years. HippUnfold enabled automated subfield segmentation and unfolded hippocampal maps. Whole‐hippocampus showed distinct lifespan trajectories: volume, quadratic; MD, negative Gamma Variate; FA, positive Gamma
Pablo Stack‐Sanchez +3 more
wiley +1 more source
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.Abstract Alzheimer's disease (AD) is a biologically heterogeneous condition with vascular, proteinopathic, metabolic, and immune processes jointly shaping its clinical expression, trajectory of progression, and response to therapeutic intervention.
Malú Gámez Tansey +32 more
wiley +1 more source
Brain and BehaviorObjective To investigate whether nicotinamide adenine dinucleotide (NAD+) supplementation can improve behavioral changes in a cuprizone‐intoxicated mouse model.
Shuang Song +6 more
doaj +1 more source
17β-Estradiol Enhances the Efficacy of Adipose-Derived Mesenchymal Stem Cells on Remyelination in Mouse Model of Multiple Sclerosis [PDF]
Acta Medica Iranica, 2012 revious studies have demonstrated the potential of monotherapy with either mesenchymal stem cells (MSCs) or estrogen in autoimmune and cuprizone models of multiple sclerosis (MS).
Vahid Pirhajati Mahabadi +7 more
doaj +2 more sources
Journal of Cellular and Molecular Medicine, Volume 30, Issue 14, July 2026.ABSTRACT The conceptual landscape of cell death has evolved beyond the traditional dichotomy of apoptosis and necrosis to encompass diverse regulated pathways including necroptosis, autophagy, ferroptosis, and pyroptosis. Necroptosis, a caspase‐independent inflammatory form of programmed cell death, has emerged as a critical driver of the pathogenesis ...
Fengxin Wang +9 more
wiley +1 more source