Results 61 to 70 of about 8,969 (212)

Cerebellar Cortical Demyelination in the Murine Cuprizone Model

Brain Pathology, 2010
AbstractIn multiple sclerosis, demyelination occurs beside the white‐matter structures and in the cerebral and cerebellar cortex. We have previously shown that, in the cuprizone model, demyelination is present not only in the corpus callosum but also in the cerebral cortex.
Thomas, Skripuletz, Jens-Heiko, Bussmann, Viktoria, Gudi, Paraskevi N, Koutsoudaki, Refik, Pul, Darius, Moharregh-Khiabani, Maren, Lindner, Martin, Stangel   +7 more
openaire   +3 more sources

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

Deep gray matter demyelination detected by magnetization transfer ratio in the cuprizone model. [PDF]

PLoS ONE, 2013
In multiple sclerosis (MS), the correlation between lesion load on conventional magnetic resonance imaging (MRI) and clinical disability is weak. This clinico-radiological paradox might partly be due to the low sensitivity of conventional MRI to detect ...
Sveinung Fjær, Lars Bø, Arvid Lundervold, Kjell-Morten Myhr, Tina Pavlin, Oivind Torkildsen, Stig Wergeland   +6 more
doaj   +1 more source

Mesenchymal stromal-cell transplants induce oligodendrocyte progenitor migration and remyelination in a chronic demyelination model. [PDF]

, 2013
Demyelinating disorders such as leukodystrophies and multiple sclerosis are neurodegenerative diseases characterized by the progressive loss of myelin that may lead toward a chronic demyelination of the brain¿s white matter, impairing normal axonal ...
A Nishiyama, A Nishiyama, A Nishiyama, A Uccelli, A Williams, AI Caplan, B Menn, BA Barres, BA Barres, C Steffenhagen, D Pastor, DL Sellers, DM Chari, DM Chari, DM Chari, F Jiang, FJ Rivera, FJ Rivera, FJ Rivera, FJ Sim, G Wolswijk, I Del Valle, J Jones, J Zhang, J Zhang, JG Boyd, JG Nutt, JM Levine, KA Nave, L Steinman, M Beck, M Cristofanilli, M Eriksdotter-Jönhagen, O Aktas, P Ye, RC Armstrong, RD McKinnon, RJ Franklin, S Kumar, T Kuhlmann, W Kohler   +40 more
core   +2 more sources

Oligodendrogenesis from neural stem cells: Perspectives for remyelinating strategies [PDF]

, 2013
Mobilization of remyelinating cells spontaneously occurs in the adult brain. These cellular resources are specially active after demyelinating episodes in early phases of multiple sclerosis (MS).
Bernardino, Liliana, Grade, Sofia, Malva, João O.   +2 more
core   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

In toxic demyelination oligodendroglial cell death occurs early and is FAS independent

Neurobiology of Disease, 2010
Oligodendroglial cell death is a frequent phenomenon of many neurological diseases, e.g. in demyelinating diseases such as multiple sclerosis (MS). The underlying mechanisms are largely unknown.
Amke Hesse, Michael Wagner, Jasmin Held, Wolfgang Brück, Gabriela Salinas-Riester, Zhenyue Hao, Ari Waisman, Tanja Kuhlmann   +7 more
doaj   +1 more source

Combination Therapy With Fingolimod and Neural Stem Cells Promotes Functional Myelination [PDF]

, 2019
Myelination, which occurs predominantly postnatally and continues throughout life, is important for proper neurologic function of the mammalian central nervous system (CNS).
Ciric, Bogoljub, Li, Xing, Lu, Xin-Yu, Ma, Cun-Gen, Rostami, A. M., Ye, Ze-Qin, Zhang, Guang-Xian, Zhang, Yuan   +7 more
core   +1 more source

Clozapine administration enhanced functional recovery after cuprizone demyelination

PLOS ONE, 2019
The atypical antipsychotic agent, clozapine, is used to treat a variety of neurological disorders including schizophrenia and Parkinson's disease and readily crosses the blood brain barrier to interact with a wide range of neuroreceptors including those for dopamine and serotonin.
Nikki Templeton, Bronwyn Kivell, Amy McCaughey-Chapman, Bronwen Connor, Anne Camille La Flamme   +4 more
openaire   +3 more sources

Teriflunomide Attenuates Demyelination and Enhances Remyelination in Organotypic Brain Slice Cultures Through Modulation of Glial Cell Dynamics

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
In an organotypic cerebellar slice culture (OSC) ex vivo demyelination model, teriflunomide has been shown to positively affect myelin preservation during demyelination and enhance remyelination. This is hypothesized as being achieved by modulating the dynamics of glial cells.
Jessica Kronenberg, Lara‐Jasmin Schröder, Henriette Reinsberg, Thomas Skripuletz, Sandra Heckers, Florian Hansmann, Wolfgang Baumgärtner, Martin Stangel, Viktoria Gudi   +8 more
wiley   +1 more source