Results 41 to 50 of about 8,969 (212)

Cognitive disturbances in the cuprizone model of multiple sclerosis [PDF]

Genes, Brain and Behavior, 2020
AbstractCognitive problems frequently accompany neurological manifestations of multiple sclerosis (MS). However, during screening of preclinical candidates, assessments of behaviour in mouse models of MS typically focus on locomotor activity. In the present study, we analysed cognitive behaviour of 9 to 10‐week‐old female C57Bl/6J mice orally ...
Maksym V. Kopanitsa, Kimmo K. Lehtimäki, Markku Forsman, Ari Suhonen, Juho Koponen, Tuukka O. Piiponniemi, Anna‐Mari Kärkkäinen, Pavlina Pavlidi, Artem Shatillo, Patrick J. Sweeney, Avia Merenlender‐Wagner, Joel Kaye, Aric Orbach, Antti Nurmi   +13 more
openaire   +4 more sources

Laquinimod ameliorates secondary brain inflammation

Neurobiology of Disease, 2020
Accumulating evidence suggests that a degenerative processes within the brain can trigger the formation of new, focal inflammatory lesions in Multiple Sclerosis (MS).
Julia Nedelcu, Christin Reinbach, Philipp Riedler, Matthias Brendel, Axel Rominger, Joel Kaye, Newshan Behrangi, Zhan Jiangshan, Christoph Schmitz, Markus Kipp   +9 more
doaj   +1 more source

Nogo-A is a reliable oligodendroglial marker in adult human and mouse CNS and in demyelinated lesions [PDF]

, 2007
The unambiguous identification of oligodendrocytes in tissue sections, especially in myelinated tracts, is often difficult. Most of the antibodies used to identify oligodendrocytes label the myelin sheath as well.
Brück, Wolfgang, Kuhlmann, Tanja, Maruschak, Brigitte, Owens, Trevor, Remington, Leah   +4 more
core   +1 more source

Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis. [PDF]

, 2012
Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide.
Aigner, Ludwig, Rivera, Francisco J
core   +2 more sources

Cuprizone short-term exposure: Astrocytic IL-6 activation and behavioral changes relevant to psychosis

Neurobiology of Disease, 2013
A growing body of evidence suggests the involvement of inflammatory processes in the pathophysiology of schizophrenia. Four- to 8-week exposure to cuprizone, a copper chelator, causes robust demyelination and has been used to build a model for multiple ...
Tomoaki Tezuka, Makoto Tamura, Mari A. Kondo, Masaki Sakaue, Kinya Okada, Kana Takemoto, Atsushi Fukunari, Keiko Miwa, Hiromitsu Ohzeki, Shin-ichi Kano, Hiroshi Yasumatsu, Akira Sawa, Yasushi Kajii   +12 more
doaj   +1 more source

Tropomyosin Receptor Kinase B Expressed in Oligodendrocyte Lineage Cells Functions to Promote Myelin Following a Demyelinating Lesion

ASN Neuro, 2020
The levels of brain-derived neurotrophic factor (BDNF) in the corpus callosum have previously been shown to have a critical impact on oligodendrocyte (OLG) lineage cells during cuprizone-elicited demyelination. In particular, BDNF+/– mice exhibit greater
Yangyang Huang, Yeri J. Song, Maria Isaac, Shir Miretzky, Ashish Patel, W. Geoffrey McAuliffe, Cheryl F. Dreyfus   +6 more
doaj   +1 more source

AxonDeepSeg: automatic axon and myelin segmentation from microscopy data using convolutional neural networks [PDF]

, 2017
Segmentation of axon and myelin from microscopy images of the nervous system provides useful quantitative information about the tissue microstructure, such as axon density and myelin thickness. This could be used for instance to document cell morphometry
Antonsanti, Pierre-Louis, Cohen-Adad, Julien, Herman, Victor, Perone, Christian Samuel, Wabartha, Maxime, Zaimi, Aldo   +5 more
core   +3 more sources

Loss of Saltation and Presynaptic Action Potential Failure in Demyelinated Axons [PDF]

, 2017
In cortical pyramidal neurons the presynaptic terminals controlling transmitter release are located along unmyelinated axon collaterals, far from the original action potential (AP) initiation site, the axon initial segment (AIS). Once initiated, APs will
Maarten H. P. Kole, Marko A. Popovic, Mustafa S. Hamada   +2 more
core   +2 more sources

AAV-Based Intracerebral Administration of BDNF Promotes Myelin Repair and Cognitive Improvement After Cuprizone-Induced Demyelination. [PDF]

Glia
Main Points AAV‐BDNF improves cognitive performance after cuprizone‐induced demyelination. BDNF promotes OPC maturation and enhances remyelination in the corpus callosum. Mitochondrial integrity is preserved through reduced swelling and improved morphology.
El Ouaamari Y, Ricciardi L, van der Heijden S, Peter A, De Waele J, Van den Bos J, Van Dam D, Calus E, Kuhn S, Marei W, Dombrowski Y, Verhoye M, Ponsaerts P, Wens I, Cools N.   +14 more
europepmc   +2 more sources

Thalamocortical-auditory network alterations following cuprizone‐induced demyelination [PDF]

Journal of Neuroinflammation, 2016
Demyelination and remyelination are common pathological processes in many neurological disorders, including multiple sclerosis (MS). Clinical evidence suggests extensive involvement of the thalamocortical (TC) system in patients suffering from MS.Using murine brain slices of the primary auditory cortex, we investigated the functional consequences of ...
Ghaffarian, Nikoo, Mesgari, Masoud, Cerina, Manuela, Göbel, Kerstin, Budde, Thomas, Speckmann, Erwin-Josef, Meuth, Sven G., Gorji, Ali   +7 more
openaire   +2 more sources