Results 41 to 50 of about 6,317 (193)

Progesterone alleviates neural behavioral deficits and demyelination with reduced degeneration of oligodendroglial cells in cuprizone-induced mice. [PDF]

PLoS ONE, 2013
Demyelination occurs widely in neurodegenerative diseases. Progesterone has neuroprotective effects, is known to reduce the clinical scores and the inflammatory response.
Jian-Ning Ye, Xing-Shu Chen, Le Su, Yun-Lai Liu, Qi-Yan Cai, Xiao-Li Zhan, Yan Xu, Shi-Fu Zhao, Zhong-Xiang Yao   +8 more
doaj   +1 more source

Dock3 protects myelin in the cuprizone model for demyelination [PDF]

Cell Death & Disease, 2014
Dedicator of cytokinesis 3 (Dock3) belongs to an atypical family of the guanine nucleotide exchange factors. It is predominantly expressed in the neural tissues and causes cellular morphological changes by activating the small GTPase Rac1. We previously reported that Dock3 overexpression protects retinal ganglion cells from excitotoxic cell death ...
Namekata, K, Kimura, A, Harada, C, Yoshida, H, Matsumoto, Y, Harada, T   +5 more
openaire   +2 more sources

Laquinimod ameliorates secondary brain inflammation

Neurobiology of Disease, 2020
Accumulating evidence suggests that a degenerative processes within the brain can trigger the formation of new, focal inflammatory lesions in Multiple Sclerosis (MS).
Julia Nedelcu, Christin Reinbach, Philipp Riedler, Matthias Brendel, Axel Rominger, Joel Kaye, Newshan Behrangi, Zhan Jiangshan, Christoph Schmitz, Markus Kipp   +9 more
doaj   +1 more source

Tropomyosin Receptor Kinase B Expressed in Oligodendrocyte Lineage Cells Functions to Promote Myelin Following a Demyelinating Lesion

ASN Neuro, 2020
The levels of brain-derived neurotrophic factor (BDNF) in the corpus callosum have previously been shown to have a critical impact on oligodendrocyte (OLG) lineage cells during cuprizone-elicited demyelination. In particular, BDNF+/– mice exhibit greater
Yangyang Huang, Yeri J. Song, Maria Isaac, Shir Miretzky, Ashish Patel, W. Geoffrey McAuliffe, Cheryl F. Dreyfus   +6 more
doaj   +1 more source

Cuprizone toxicity and Garcinia kola biflavonoid complex activity on hippocampal morphology and neurobehaviour

Heliyon, 2019
Cuprizone-induced neurotoxicity has been employed to study the biology of remyelination in experimental models of multiple sclerosis. This study was aimed at determining the role of kolaviron, a biflavonoid from Garcinia kola, in mitigating the damaging ...
G.O. Omotoso, O.J. Olajide, I.T. Gbadamosi, J.O. Adebayo, B.U. Enaibe, O.B. Akinola, B.V. Owoyele   +6 more
doaj   +1 more source

Imaging Cuprizone-Induced Mitochondrial Dysfunction [PDF]

, 2020
Abstract Cuprizone is a copper chelator that induces mitochondrial dysfunction in myelin-producing oligodendrocytes and hepatic cells. Inhibition of oxidative phosphorylation has been proposed as a potential mechanism, but the exact relationship between shape changes and metabolic alterations is not well-understood.
Lucille A. Ray, Gardenia Pacheco, Alexandra Taraboletti, Michael C. Konopka, Leah P. Shriver   +4 more
openaire   +1 more source

Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination [PDF]

The Journal of Neuroscience, 2020
Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS. Cuprizone (CZ), a copper chelator, is widely used to study demyelination and remyelination in the CNS, in the context of MS. However, the mechanisms underlying oligodendrocyte (OL) cell loss and demyelination are not known.
Priya Jhelum, Eva Santos-Nogueira, Wulin Teo, Alice Haumont, Isadora Lenoël, Peter K. Stys, Samuel David   +6 more
openaire   +2 more sources

COVID‐19 Amplifies Sex‐Specific Dopamine and Glial Responses in a Parkinson's Disease Mouse Model

Movement Disorders, EarlyView.
Abstract Background Exposure to environmental agents, including viral infections, may increase Parkinson's disease (PD) susceptibility, especially in males, but the neurodegenerative risk extent of COVID‐19 remains uncertain. Objectives We investigated the plausible link between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and
Ifeoluwa Awogbindin, Mélanie Bourque, Marc Morissette, Marie‐Ève Hamelin, Chantal Rhéaume, Jared VanderZwaag, Antonia Landwehr, Disha Patel, Guy Boivin, Marie‐Ève Tremblay, Thérèse Di Paolo   +10 more
wiley   +1 more source

Cuprizone short-term exposure: Astrocytic IL-6 activation and behavioral changes relevant to psychosis

Neurobiology of Disease, 2013
A growing body of evidence suggests the involvement of inflammatory processes in the pathophysiology of schizophrenia. Four- to 8-week exposure to cuprizone, a copper chelator, causes robust demyelination and has been used to build a model for multiple ...
Tomoaki Tezuka, Makoto Tamura, Mari A. Kondo, Masaki Sakaue, Kinya Okada, Kana Takemoto, Atsushi Fukunari, Keiko Miwa, Hiromitsu Ohzeki, Shin-ichi Kano, Hiroshi Yasumatsu, Akira Sawa, Yasushi Kajii   +12 more
doaj   +1 more source

The Maintenance of Dysmyelinated Small‐Diameter Axons by 14‐3‐3s in the Central Nervous System

Glia, Volume 74, Issue 11, November 2026.
Dysmyelinated small‐diameter axons are maintained in teneurin‐4 deficient mice at the age of 1 year, while axonal damage is observed. 14‐3‐3s are highly expressed and suppress the progression of the damage in these axons. ABSTRACT In the central nervous system, myelin formed around nerve axons by oligodendrocyte enables efficient conduction of action ...
Nanako Yamada, Hinako Saito, Riko Takahashi, Mio Fujisato, Yukina Hosoda, Binri Sasaki, Momona Yamada, Sakurako Abe, Chikako Hayashi, Akira Yoshimoto, Ryunosuke Ohkawa, Tomal Julian Matt, Florence M Bareyre, Stefan Berghoff, Mikael Simons, Nobuharu Suzuki   +15 more
wiley   +1 more source