Results 41 to 50 of about 6,444 (163)
Neurobiology of Disease, 2013 A growing body of evidence suggests the involvement of inflammatory processes in the pathophysiology of schizophrenia. Four- to 8-week exposure to cuprizone, a copper chelator, causes robust demyelination and has been used to build a model for multiple ...
Tomoaki Tezuka +12 more
doaj +1 more source
Body‐integrated photonic biosensors: Illuminating the path to active healthcare
FlexMat, EarlyView.Body‐integrated photonic biosensors are promising tools for active healthcare. These optical devices can be worn, implanted, or swallowed to monitor health signals continuously. This review introduces key sensing modalities, including fluorescence, colorimetry, SPR, LSPR, SERS, and light‐modulating materials.
Jiayue Gu +10 more
wiley +1 more source
Neurotoxicity of Cuprizone in Female and Male Rats: Electrophysiological Observations
, 2018 Cuprizone induces massive demyelination in the CNS; however, the effects of cuprizone on the functions of the peripheral nervous system, as well as differential effects it may exert on males and females, have not yet been studied.
Ozcan, M., Unsal, C., ÖZCAN, Mustafa
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COVID‐19 Amplifies Sex‐Specific Dopamine and Glial Responses in a Parkinson's Disease Mouse Model
Movement Disorders, EarlyView.Abstract Background Exposure to environmental agents, including viral infections, may increase Parkinson's disease (PD) susceptibility, especially in males, but the neurodegenerative risk extent of COVID‐19 remains uncertain. Objectives We investigated the plausible link between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and
Ifeoluwa Awogbindin +10 more
wiley +1 more source
Leucine Supplementation in Cuprizone-Induced Oligodendrocyte Toxicity [PDF]
, 2019 Cuprizone is a copper chelator that induces demyelination in the central nervous system when fed to mice. This compound is thought to target Complex IV and disrupt mitochondrial metabolism leading to loss of myelin-producing oligodendrocytes.
Ley, Michael
core
Diagnostics, 2020 This study quantitatively measured the changes in metabolites in the hippocampal lesions of a rat model of cuprizone-induced demyelination as detected using in vivo 7 T proton magnetic resonance spectroscopy.
Do-Wan Lee +7 more
doaj +1 more source
Molecular Neurodegeneration, 2022 Background Microglia regulate the response to injury and disease in the brain and spinal cord. In white matter diseases microglia may cause demyelination. However, how microglia respond and regulate demyelination is not fully understood.
Sameera Zia +15 more
doaj +1 more source
Potential of Ginkgo biloba Extract to Intervene in Chronic Inflammation‐Related Diseases
Phytotherapy Research, EarlyView.Chronic inflammation is a pathological mechanism underpinning many diseases. Ginkgo biloba extract (GBE) is well known for its anti‐inflammatory property. GBE and its active constituents have been shown to attenuate pro‐inflammatory cytokine production, suppress nuclear factor kappa B activation, restore redox homeostasis, and modulate disease‐relevant
Yipeng Lin +7 more
wiley +1 more source
Clozapine enhanced recovery after cessation of cuprizone administration.
, 2019 (a) Experimental design for investigating remyelination events. Mice were fed a diet containing 0.3% cuprizone for 6 weeks. After the 5th week of cuprizone, clozapine or vehicle treatment began.
Bronwen Connor (614009) +4 more
core +1 more source
Quantifizierung & Visualisierung von neurodegenerativen Aspekten der Multiplen Sklerose im Cuprizone-Mausmodell: Neuronenverlust, axonaler mitochondrialer Schaden [PDF]
, 2022 Neurodegeneration, insbesondere Neuronenverlust sowie axonaler Schaden tragen maßgeblich zur Krankheitsprogression bei an Multipler Sklerose erkrankten Patienten bei.
Schmutz, Selina
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