Results 41 to 50 of about 5,891 (192)
Brain and Behavior, 2019 Introduction The aim of this study was to investigate the effects of cuprizone on adult hippocampal neurogenesis in naïve mice. Additionally, we also studied how melatonin affects the neuronal degeneration induced by cuprizone.
Woosuk Kim +11 more
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Progesterone alleviates neural behavioral deficits and demyelination with reduced degeneration of oligodendroglial cells in cuprizone-induced mice. [PDF]
PLoS ONE, 2013 Demyelination occurs widely in neurodegenerative diseases. Progesterone has neuroprotective effects, is known to reduce the clinical scores and the inflammatory response.
Jian-Ning Ye +8 more
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Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model
International Journal of Molecular Sciences, 2022 Remyelination therapies, which are currently under development, have a great potential to delay, prevent or even reverse disability in multiple sclerosis patients. Several models are available to study the effectiveness of novel compounds in vivo, among which is the cuprizone model.
Heinig Leo, Markus Kipp
openaire +2 more sources
Neurotoxicity of Cuprizone in Female and Male Rats: Electrophysiological Observations [PDF]
, 2018 Cuprizone induces massive demyelination in the CNS; however, the effects of cuprizone on the functions of the peripheral nervous system, as well as differential effects it may exert on males and females, have not yet been studied.
Ozcan, M., Unsal, C.
core +1 more source
Laquinimod ameliorates secondary brain inflammation
Neurobiology of Disease, 2020 Accumulating evidence suggests that a degenerative processes within the brain can trigger the formation of new, focal inflammatory lesions in Multiple Sclerosis (MS).
Julia Nedelcu +9 more
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Effect of cuprizone on thymic epithelial cells. [PDF]
, 2015 Four week-old male mice were treated with cuprizone for one week, then immune-staining (A) with FITC-labelled anti-EpCAM1 (green) and PE-labelled anti-Ly-51 (red) antibodies was performed on thymic sections of untreated (Control) and cuprizone-treated ...
Peter Acs (751324) +10 more
core +1 more source
ASN Neuro, 2020 The levels of brain-derived neurotrophic factor (BDNF) in the corpus callosum have previously been shown to have a critical impact on oligodendrocyte (OLG) lineage cells during cuprizone-elicited demyelination. In particular, BDNF+/– mice exhibit greater
Yangyang Huang +6 more
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Characterisation of cuprizone-induced cell death. [PDF]
, 2015 Four week-old male mice were treated with cuprizone for one week. Type of cell death was determined using flow cytometry following double staining with FITC-labelled AnnexinV and propidium iodide thymus suspensions of untreated (Control, grey bars) and ...
Peter Acs (751324) +10 more
core +1 more source
Dock3 protects myelin in the cuprizone model for demyelination [PDF]
Cell Death & Disease, 2014 Dedicator of cytokinesis 3 (Dock3) belongs to an atypical family of the guanine nucleotide exchange factors. It is predominantly expressed in the neural tissues and causes cellular morphological changes by activating the small GTPase Rac1. We previously reported that Dock3 overexpression protects retinal ganglion cells from excitotoxic cell death ...
Namekata, K +5 more
openaire +2 more sources
Heliyon, 2019 Cuprizone-induced neurotoxicity has been employed to study the biology of remyelination in experimental models of multiple sclerosis. This study was aimed at determining the role of kolaviron, a biflavonoid from Garcinia kola, in mitigating the damaging ...
G.O. Omotoso +6 more
doaj +1 more source