Results 11 to 20 of about 6,317 (193)
Strain differences in cuprizone induced demyelination [PDF]
Cell & Bioscience, 2017 Background Multiple sclerosis (MS) is a severe neurological disorder, characterized by demyelination of the central nervous system (CNS), and with a prevalence of greater than 2 million people worldwide.
Qili Yu +6 more
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Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination [PDF]
Molecular Neurodegeneration, 2022 Background The dietary consumption of cuprizone – a copper chelator – has long been known to induce demyelination of specific brain structures and is widely used as model of multiple sclerosis.
Martin Zirngibl +4 more
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Evaluation of the cuprizone model [PDF]
, 2022 Diese Arbeit sollte das cuprizone Mäusemodell herstellen und pathologischen änderungen kennzeichnen, die zu den menschlichen demyelinisierenden Krankheiten relevant sind.
Awn, Najmy
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An Alternative Cuprizone-Induced Demyelination and Remyelination Mouse Model
ASN Neuro, 2017 The cuprizone model is a well-established and investigated paradigm to study demyelination and remyelination in rodents. Cuprizone is usually administrated by mixing in the powdered or pelleted rodent chow.
Wei Zhen +5 more
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Cognitive disturbances in the cuprizone model of multiple sclerosis [PDF]
Genes, Brain and Behavior, 2020 AbstractCognitive problems frequently accompany neurological manifestations of multiple sclerosis (MS). However, during screening of preclinical candidates, assessments of behaviour in mouse models of MS typically focus on locomotor activity. In the present study, we analysed cognitive behaviour of 9 to 10‐week‐old female C57Bl/6J mice orally ...
Maksym V. Kopanitsa +13 more
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Cuprizone feeding induces swollen astrocyte endfeet
Pflügers Archiv - European Journal of Physiology, 2022 AbstractThe cuprizone model is a widely used model to study the pathogenesis of multiple sclerosis (MS). Due to the selective loss of mature oligodendrocytes and myelin, it is mainly being used to study demyelination and the mechanisms of remyelination, as well as the efficiency of compounds or therapeutics aiming at remyelination.
Petra Fallier-Becker +2 more
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Development and validation of a novel HILIC method for the quantification of low-levels of cuprizone in cuprizone-containing chow [PDF]
Scientific Reports, 2021 Cuprizone is an amide compound that has been wildly used in various animal studies, such as in the investigation of remyelination in mouse model. It is important to control the amount of cuprizone dosed in animals to be consistent as different amounts ...
Fengmei Zheng, Yiqing Lin, Pierre Boulas
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Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: effects of antipsychotics [PDF]
Frontiers in Behavioral Neuroscience, 2010 Recent human studies suggest a role for altered oligodendrocytes in the pathophysiology of schizophrenia. Our recent animal study has reported some schizophrenia-like behaviors in mice exposed to cuprizone (Xu et al., 2009), a copper chelator that has ...
Haiyun Xu +4 more
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PLoS ONE, 2020 The cuprizone induced animal model of demyelination is characterized by demyelination in many regions of the brain with high levels of demyelination in the corpus callosum as well as changes in neuronal function by 4-6 weeks of exposure.
John Shelestak +7 more
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Unravelling the chemical nature of copper cuprizone
Dalton Transactions, 2007 During the last 50 years, formation of the highly chromogenic copper cuprizone complex has been exploited for spectrophotometric determinations of copper although the precise chemical nature of the resulting species has never been ascertained; we eventually show here, in contrast to current opinion, that copper cuprizone is a copper(III)complex.
MESSORI, LUIGI +5 more
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