Results 11 to 20 of about 8,969 (212)
Strain differences in cuprizone induced demyelination [PDF]
Cell & Bioscience, 2017 Background Multiple sclerosis (MS) is a severe neurological disorder, characterized by demyelination of the central nervous system (CNS), and with a prevalence of greater than 2 million people worldwide.
Qili Yu +6 more
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Cuprizone Intoxication Results in Myelin Vacuole Formation [PDF]
Frontiers in Cellular Neuroscience, 2022 Myelin damage is a histopathological hallmark of multiple sclerosis lesions. Results of post mortem studies suggest that impaired myelin-axon interaction characterized by focal myelin detachments is an early event during lesion genesis. In this study, we
Sarah Joost +8 more
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Development and validation of a novel HILIC method for the quantification of low-levels of cuprizone in cuprizone-containing chow [PDF]
Scientific Reports, 2021 Cuprizone is an amide compound that has been wildly used in various animal studies, such as in the investigation of remyelination in mouse model. It is important to control the amount of cuprizone dosed in animals to be consistent as different amounts ...
Fengmei Zheng, Yiqing Lin, Pierre Boulas
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A New Model of Cuprizone-Mediated Demyelination/Remyelination
ASN Neuro, 2014 In the central nervous system, demyelinating diseases, such as multiple sclerosis, result in devastating long-term neurologic damage, in part because of the lack of effective remyelination in the adult human brain.
Hilary H. Sachs +4 more
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Depletion of Microglia Increases Cortical Oligodendrocyte Density During Remyelination. [PDF]
GliaCuprizone demyelination induces transient reactive states in deep cortical microglia (MG) through early recovery. Depleting MG in recovery increases the number of deep cortical mature/pre‐myelinating oligodendrocytes. Deep cortical reactive MG reduce oligodendrocyte density after demyelination.
Loo HK +5 more
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International Journal of Molecular Sciences, 2023 The Cuprizone mouse model is widely used in studies on de- and remyelination. In the hands of different experimenters, the Cuprizone concentrations that lead to comparable levels of demyelination differ considerably. The reasons for this variability are unknown.
Malena Beecken +8 more
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Cuprizone feeding induces swollen astrocyte endfeet
Pflügers Archiv - European Journal of Physiology, 2022 AbstractThe cuprizone model is a widely used model to study the pathogenesis of multiple sclerosis (MS). Due to the selective loss of mature oligodendrocytes and myelin, it is mainly being used to study demyelination and the mechanisms of remyelination, as well as the efficiency of compounds or therapeutics aiming at remyelination.
Petra Fallier-Becker +2 more
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Sex Differences in the Behavioural Aspects of the Cuprizone-Induced Demyelination Model in Mice
Brain Sciences, 2022 Multiple sclerosis is an autoimmune disease characterised by demyelination in the central nervous system. The cuprizone-induced demyelination model is often used in mice to test novel treatments for multiple sclerosis.
Kelly F. Paton +3 more
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Imaging Cuprizone-Induced Mitochondrial Dysfunction [PDF]
, 2020 AbstractCuprizone is a copper chelator that induces mitochondrial dysfunction in myelin-producing oligodendrocytes and hepatic cells. Inhibition of oxidative phosphorylation has been proposed as a potential mechanism, but the exact relationship between shape changes and metabolic alterations is not well-understood.
Lucille A. Ray +4 more
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Protective effects of erythropoietin against cuprizone-induced oxidative stress and demyelination in the mouse corpus callosum [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis.
Iraj Ragerdi Kashani +7 more
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