Results 31 to 40 of about 26,726 (251)
Innate and adaptive immune mechanisms regulating central nervous system remyelination
, 2022 Neuroinflammation is a hallmark of many neurodegenerative diseases and is considered their underlying cause. However, certain aspects of neuroinflammation favour beneficial outcomes after damage including the regeneration of myelin (remyelination).
Creswell, Richard +3 more
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Neurobiology of Disease, 2008 Osteopontin (OPN) is a key immunoregulator in the autoimmune-mediated demyelinating disease multiple sclerosis. OPN may also play a role in the remyelination since it is 1) a ligand for αV integrins, several of which regulate the properties of the ...
Chao Zhao +3 more
doaj +1 more source
Promoting remyelination in multiple sclerosis. [PDF]
, 2019 The greatest unmet need in multiple sclerosis (MS) are treatments that delay, prevent or reverse progression. One of the most tractable strategies to achieve this is to therapeutically enhance endogenous remyelination; doing so restores nerve conduction ...
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Effects of calcitriol and fingolimod on remyelination in the cuprizone model [PDF]
, 2020 Multiple sclerosis (MS) is a chronic disease characterized by inflammation, demyelination, and neurodegeneration of the central nervous system (CNS). There is no cure. Current treatments target the autoimmune aspects of MS but do not directly improve CNS
Nystad, Agnes Elisabeth
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Astrocytes in myelination and remyelination
Neuroscience Letters, 2019 Astrocytes are known to play critical roles in central nervous system development, homeostasis, and response to injury. In addition to well-defined functions in synaptic signalling and blood-brain barrier control, astrocytes are now emerging as important contributors to white matter health.
Irene Molina-Gonzalez +1 more
openaire +3 more sources
Experimental models of demyelination and remyelination
Neurología (English Edition), 2020 Experimental animal models constitute a useful tool to deepen our knowledge of central nervous system disorders. In the case of multiple sclerosis, however, there is no such specific model able to provide an overview of the disease; multiple models covering the different pathophysiological features of the disease are therefore necessary.We reviewed the
L. Torre-Fuentes +5 more
openaire +3 more sources
Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis. [PDF]
, 2020 Regenerative medicines that promote remyelination in multiple sclerosis (MS) are making the transition from laboratory to clinical trials. While animal models provide the experimental flexibility to analyze mechanisms of remyelination, here we discuss ...
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Frontiers in ImmunologyObjectiveNeuropsychiatric systemic lupus erythematosus (NPSLE) is among the most challenging manifestations of systemic lupus erythematosus (SLE), affecting the central and peripheral nervous systems with diverse symptoms.
Karim Matmat +10 more
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, 2013 The increasing effectiveness of new disease-modifying drugs that suppress disease activity in multiple sclerosis has opened up opportunities for regenerative medicines that enhance remyelination and potentially slow disease progression.
Jeffrey K. Huang +39 more
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rHIgM22 enhances remyelination in the brain of the cuprizone mouse model of demyelination
Neurobiology of Disease, 2017 Failure of oligodendrocyte precursor cells (OPCs) to differentiate and remyelinate axons is thought to be a major cause of the limited ability of the central nervous system to repair plaques of immune-mediated demyelination in multiple sclerosis (MS ...
Ariana P. Mullin +8 more
doaj +1 more source