Results 31 to 40 of about 22,271 (244)
Remyelination Therapy in Multiple Sclerosis
Frontiers in Neurology, 2015 Multiple Sclerosis (MS) is an immune-mediated disorder of the central nervous system that results in destruction of the myelin sheath that surrounds axons and eventual neurodegeneration.
Danielle E. Harlow +2 more
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A New Model of Cuprizone-Mediated Demyelination/Remyelination
ASN Neuro, 2014 In the central nervous system, demyelinating diseases, such as multiple sclerosis, result in devastating long-term neurologic damage, in part because of the lack of effective remyelination in the adult human brain.
Hilary H. Sachs +4 more
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Brain region dependent molecular signatures and myelin repair following chronic demyelination
Frontiers in Cellular Neuroscience, 2023 Multiple sclerosis (MS) is the most prevalent demyelinating disease of the central nervous system, characterized by myelin destruction, axonal degeneration, and progressive loss of neurological functions.
Grace Samtani +8 more
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Neurobiology of Disease, 2008 Osteopontin (OPN) is a key immunoregulator in the autoimmune-mediated demyelinating disease multiple sclerosis. OPN may also play a role in the remyelination since it is 1) a ligand for αV integrins, several of which regulate the properties of the ...
Chao Zhao +3 more
doaj +1 more source
Pharmaceuticals, 2021 Inflammatory attacks and demyelination in the central nervous system (CNS) are the key factors responsible for the damage of neurons in multiple sclerosis (MS).
Viktoria Gudi +4 more
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Frontiers in ImmunologyObjectiveNeuropsychiatric systemic lupus erythematosus (NPSLE) is among the most challenging manifestations of systemic lupus erythematosus (SLE), affecting the central and peripheral nervous systems with diverse symptoms.
Karim Matmat +10 more
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Astrocytes in myelination and remyelination
Neuroscience Letters, 2019 Astrocytes are known to play critical roles in central nervous system development, homeostasis, and response to injury. In addition to well-defined functions in synaptic signalling and blood-brain barrier control, astrocytes are now emerging as important contributors to white matter health.
Irene Molina-Gonzalez +1 more
openaire +4 more sources
rHIgM22 enhances remyelination in the brain of the cuprizone mouse model of demyelination
Neurobiology of Disease, 2017 Failure of oligodendrocyte precursor cells (OPCs) to differentiate and remyelinate axons is thought to be a major cause of the limited ability of the central nervous system to repair plaques of immune-mediated demyelination in multiple sclerosis (MS ...
Ariana P. Mullin +8 more
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Experimental models of demyelination and remyelination
Neurología (English Edition), 2020 Experimental animal models constitute a useful tool to deepen our knowledge of central nervous system disorders. In the case of multiple sclerosis, however, there is no such specific model able to provide an overview of the disease; multiple models covering the different pathophysiological features of the disease are therefore necessary.We reviewed the
L. Torre-Fuentes +5 more
openaire +3 more sources
In vivo imaging reveals mature Oligodendrocyte division in adult Zebrafish
Cell Regeneration, 2021 Whether mature oligodendrocytes (mOLs) participate in remyelination has been disputed for several decades. Recently, some studies have shown that mOLs participate in remyelination by producing new sheaths.
Suqi Zou, Bing Hu
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