Results 31 to 40 of about 25,880 (231)

Conduction in segmentally demyelinated mammalian central axons. [PDF]

, 1997
The prominent symptoms associated with central demyelinating diseases such as multiple sclerosis (MS) are primarily caused by conduction deficits in affected axons.
Paul A. Felts, Baker, Theresa A., Theresa A. Baker, Felts, PA, Smith, KJ, Smith, Kenneth J., Felts, Paul A.; id_orcid, Kenneth J. Smith, Baker, TA   +8 more
core   +1 more source

Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination

Neurobiology of Disease, 2008
Osteopontin (OPN) is a key immunoregulator in the autoimmune-mediated demyelinating disease multiple sclerosis. OPN may also play a role in the remyelination since it is 1) a ligand for αV integrins, several of which regulate the properties of the ...
Chao Zhao, Stephen P.J. Fancy, Charles ffrench-Constant, Robin J.M. Franklin   +3 more
doaj   +1 more source

Brain region dependent molecular signatures and myelin repair following chronic demyelination

Frontiers in Cellular Neuroscience, 2023
Multiple sclerosis (MS) is the most prevalent demyelinating disease of the central nervous system, characterized by myelin destruction, axonal degeneration, and progressive loss of neurological functions.
Grace Samtani, Grace Samtani, Sunja Kim, Danielle Michaud, Andrew E. Hillhouse, Joseph A. Szule, Kranti Konganti, Jianrong Li, Jianrong Li   +8 more
doaj   +1 more source

The species specific effects of Mesenchymal stem cell conditioned medium on proliferating mouse and rat adult neural stem, progenitor cells [PDF]

, 2012
Adult stem cells reside in different tissues and organs of the adult organism. Among these cells are Mesenchymal stem cells (MSCs) and neural stem and progenitor cells (NSPCs).
Dechant, Franz - Xaver
core   +1 more source

remyelination [PDF]

, 2013
The increasing effectiveness of new disease-modifying drugs that suppress disease activity in multiple sclerosis has opened up opportunities for regenerative medicines that enhance remyelination and potentially slow disease progression.
Jeffrey K. Huang, Moritz J. Rossner, Rundle, Jon, Syed, Yasir Ahmed, Kotter, Mark R., Yasir A. Syed, Zhao, Chao, Matthew W. B. Trotter, Gert Lubec, Baer, Alexandra, Ginez A. González, Robin J. M. Franklin, Alexandra Baer, Rossner, Moritz J., Jon Rundle, Lubec, Gert, Huang, Jeffrey K., Trotter, Matthew W. B., Mark R. Kotter, Hofer, Matthias P., Matthias P. Hofer, González, Ginez A., Myrta, Szymon, Syed, Yasir A., Szymon Myrta, Franklin, Robin J. M., Chao Zhao   +26 more
core   +1 more source

Astrocytes in myelination and remyelination

Neuroscience Letters, 2019
Astrocytes are known to play critical roles in central nervous system development, homeostasis, and response to injury. In addition to well-defined functions in synaptic signalling and blood-brain barrier control, astrocytes are now emerging as important contributors to white matter health.
Irene Molina-Gonzalez, Veronique E. Miron   +1 more
openaire   +3 more sources

Experimental models of demyelination and remyelination

Neurología (English Edition), 2020
Experimental animal models constitute a useful tool to deepen our knowledge of central nervous system disorders. In the case of multiple sclerosis, however, there is no such specific model able to provide an overview of the disease; multiple models covering the different pathophysiological features of the disease are therefore necessary.We reviewed the
L. Torre-Fuentes, L. Moreno-Jiménez, V. Pytel, J.A. Matías-Guiu, U. Gómez-Pinedo, J. Matías-Guiu   +5 more
openaire   +3 more sources

A multidimensional analysis of neuropsychiatric lupus: clinical, biological and imaging insights from systematic evidence

Frontiers in Immunology
ObjectiveNeuropsychiatric systemic lupus erythematosus (NPSLE) is among the most challenging manifestations of systemic lupus erythematosus (SLE), affecting the central and peripheral nervous systems with diverse symptoms.
Karim Matmat, Hélène Jamann, Amin Maazouzi, Amin Maazouzi, Kévin Bigaut, Kévin Bigaut, Michel Maitre, Jérôme De Seze, Jérôme De Seze, Ayikoé-Guy Mensah-Nyagan, Hélène Jeltsch-David   +10 more
doaj   +1 more source

Regenerative Effects of CDP-Choline: A Dose-Dependent Study in the Toxic Cuprizone Model of De- and Remyelination

Pharmaceuticals, 2021
Inflammatory attacks and demyelination in the central nervous system (CNS) are the key factors responsible for the damage of neurons in multiple sclerosis (MS).
Viktoria Gudi, Nora Schäfer, Stefan Gingele, Martin Stangel, Thomas Skripuletz   +4 more
doaj   +1 more source

rHIgM22 enhances remyelination in the brain of the cuprizone mouse model of demyelination

Neurobiology of Disease, 2017
Failure of oligodendrocyte precursor cells (OPCs) to differentiate and remyelinate axons is thought to be a major cause of the limited ability of the central nervous system to repair plaques of immune-mediated demyelination in multiple sclerosis (MS ...
Ariana P. Mullin, Charlene Cui, Yu Wang, Jing Wang, Erika Troy, Anthony O. Caggiano, Tom J. Parry, Raymond W. Colburn, Elias Pavlopoulos   +8 more
doaj   +1 more source