Results 31 to 40 of about 34,938 (236)
Local cholesterol metabolism orchestrates remyelination [PDF]
Trends in Neurosciences, 2022 Cholesterol is an essential component of all cell membranes and particularly enriched in myelin membranes. Myelin membranes are a major target of immune attacks in the chronic neurological disorder multiple sclerosis (MS). During demyelinating insults, cholesterol is released from damaged myelin, increasing local levels of this unique lipid and ...
Stefan A. Berghoff +2 more
openaire +4 more sources
Pharmaceuticals, 2021 Inflammatory attacks and demyelination in the central nervous system (CNS) are the key factors responsible for the damage of neurons in multiple sclerosis (MS).
Viktoria Gudi +4 more
doaj +1 more source
Mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis. [PDF]
, 2015 Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits.
Biswas, Sangita +5 more
core +3 more sources
Oligodendrocytes, BK channels and remyelination [PDF]
F1000Research, 2021 Oligodendrocytes wrap multiple lamellae of their membrane, myelin, around axons of the central nervous system (CNS), to improve impulse conduction. Myelin synthesis is specialised and dynamic, responsive to local neuronal excitation. Subtle pathological insults are sufficient to cause significant neuronal metabolic impairment, so myelin preservation is
Maddalena Rupnik +2 more
openaire +3 more sources
Learning Myelin Content in Multiple Sclerosis from Multimodal MRI through Adversarial Training [PDF]
, 2018 Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). A reliable measure of the tissue myelin content is therefore essential for the understanding of the physiopathology of MS, tracking progression and assessing ...
Ayache, Nicholas +6 more
core +3 more sources
Remyelination in multiple sclerosis
Journal of the Neurological Sciences, 2003 Remyelination in multiple sclerosis (MS) lesions has been described in several studies. It depends on the presence of myelinating oligodendrocytes and a functional interaction between these myelinating cells and axons. The imaging signal of remyelination in magnetic resonance imaging or spectroscopy is not yet defined.
Brück, Wolfgang +2 more
openaire +3 more sources
Glia Disease and Repair—Remyelination [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 The inability of the mammalian central nervous system (CNS) to undergo spontaneous regeneration has long been regarded as a central tenet of neurobiology. However, although this is largely true of the neuronal elements of the adult mammalian CNS, save for discrete populations of granular neurons, the same is not true of its glial elements.
Franklin, Robin J M, Goldman, Steven A
openaire +3 more sources
Frontiers in ImmunologyObjectiveNeuropsychiatric systemic lupus erythematosus (NPSLE) is among the most challenging manifestations of systemic lupus erythematosus (SLE), affecting the central and peripheral nervous systems with diverse symptoms.
Karim Matmat +10 more
doaj +1 more source
rHIgM22 enhances remyelination in the brain of the cuprizone mouse model of demyelination
Neurobiology of Disease, 2017 Failure of oligodendrocyte precursor cells (OPCs) to differentiate and remyelinate axons is thought to be a major cause of the limited ability of the central nervous system to repair plaques of immune-mediated demyelination in multiple sclerosis (MS ...
Ariana P. Mullin +8 more
doaj +1 more source
In vivo imaging reveals mature Oligodendrocyte division in adult Zebrafish
Cell Regeneration, 2021 Whether mature oligodendrocytes (mOLs) participate in remyelination has been disputed for several decades. Recently, some studies have shown that mOLs participate in remyelination by producing new sheaths.
Suqi Zou, Bing Hu
doaj +1 more source