Results 51 to 60 of about 34,938 (236)

Remyelinating Pharmacotherapies in Multiple Sclerosis [PDF]

Neurotherapeutics, 2017
We have witnessed major successes in the development of effective immunomodulatory therapies capable of reducing adaptive immune-mediated myelin damage in MS over the last 30 years. However, until it is possible to prevent MS or initiate treatment before it has already caused lesions there is a need to repair myelin damage to prevent further axonal ...
Riley M. Bove, Ari J Green
openaire   +4 more sources

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Oligodendroglial primary cilium heterogeneity during development and demyelination/remyelination

Frontiers in Cellular Neuroscience, 2022
The primary cilium (PC) has emerged as an indispensable cellular antenna essential for signal transduction of important cell signaling pathways. The rapid acquisition of knowledge about PC biology has raised attention to PC as a therapeutic target in ...
Giada Delfino, Giada Delfino, Giada Delfino, Karelle Bénardais, Karelle Bénardais, Karelle Bénardais, Karelle Bénardais, Julien Graff, Julien Graff, Brigitte Samama, Brigitte Samama, Brigitte Samama, Brigitte Samama, Maria Cristina Antal, Maria Cristina Antal, Maria Cristina Antal, Maria Cristina Antal, M. Said Ghandour, M. Said Ghandour, Nelly Boehm, Nelly Boehm, Nelly Boehm, Nelly Boehm   +22 more
doaj   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Positive effect of evobrutinib in CNS remyelination models and lack of synergy with clemastine—A dose response study

Multiple Sclerosis Journal - Experimental, Translational and Clinical
Background To recover normal functions, remyelination in multiple sclerosis is crucial. Although endogenous remyelination occurs, it is often insufficient, and finding molecules promoting repair of demyelinated lesions is needed.
E. Martin, M.S. Aigrot, N. Frère, R. Lepaulmier, B. Stankoff, U. Boschert, C. Lubetzki, B. Zalc   +7 more
doaj   +1 more source

Regeneration of myelin sheaths of normal length and thickness in the zebrafish CNS correlates with growth of axons in caliber.

PLoS ONE, 2017
Demyelination is observed in numerous diseases of the central nervous system, including multiple sclerosis (MS). However, the endogenous regenerative process of remyelination can replace myelin lost in disease, and in various animal models. Unfortunately,
Marja J Karttunen, Tim Czopka, Marieke Goedhart, Jason J Early, David A Lyons   +4 more
doaj   +1 more source

Central Nervous System Remyelination: Roles of Glia and Innate Immune Cells

Frontiers in Molecular Neuroscience, 2019
In diseases such as multiple sclerosis (MS), inflammation can injure the myelin sheath that surrounds axons, a process known as demyelination. The spontaneous regeneration of myelin, called remyelination, is associated with restoration of function and ...
Charbel S. Baaklini, Khalil S. Rawji, Greg J. Duncan, Madelene F. S. Ho, Jason R. Plemel   +4 more
doaj   +1 more source

Transplantation of Ciliary Neurotrophic Factor-Expressing Adult Oligodendrocyte Precursor Cells Promotes Remyelination and Functional Recovery after SpinalCord Injury [PDF]

, 2010
Demyelination contributes to the dysfunction after traumatic spinal cord injury (SCI). We explored whether the combination of neurotrophic factors and transplantation of adult rat spinal cord oligodendrocyte precursor cells (OPCs) could enhance ...
Cao, Qilin, Cheng, Xiaoxin, DeVries, William H., He, Qian, Howard, Russell M., Kim, Dong H., Magnuson, David S. K., Shields, Christopher B., Wang, Yaping, Whittemore, Scott R., Xu, Xiao-Ming, Zhang, Yiping   +11 more
core   +1 more source

Ultrasound Activated Piezoelectric Dural Patches to Drive Endogenous Neural Stem Cell–Mediated Repair Traumatic Brain Injury

Advanced Science, EarlyView.
This study presents a wireless, non‐invasive strategy for neural repair by developing a biodegradable piezoelectric dural patch that, under transcranial ultrasound, generates localized electrical fields to drive endogenous neural stem cells toward neuronal differentiation and functional integration.
Pengbo Zhou, Qingyuan Wu, Yang Wu, Runzhe Huang, Wei Li, Hanjie Niu, Hongtao Sun, Huiyu Liu   +7 more
wiley   +1 more source

Evidence for down-regulation of beta-2-adreno-ceptors in cirrhotic patients with severe ascites [PDF]

, 1986
The density and affinity of beta-2-adrenoceptors on mononuclear cells from peripheral blood were studied in fifteen patients with cirrhosis of different severity and in thirteen controls. There was no significant difference between cirrhotic patients and
AlexanderL. Gerbes, Arthur, Bihari, Boyum, Burghardt, Burroughs, Dieter Jüngst, Fraser, Gustav Paumgartner, Heinsimer, Henriksen, Jenkins, Jörg Remien, Kroeger, Lebrec, Lebrec, Lebrec, Mann, Molinoff, Pugh, Scatchard, Terblanche, Tilman Sauerbruch   +22 more
core   +1 more source