Results 51 to 60 of about 25,880 (231)
PLoS ONE, 2017 Demyelination is observed in numerous diseases of the central nervous system, including multiple sclerosis (MS). However, the endogenous regenerative process of remyelination can replace myelin lost in disease, and in various animal models. Unfortunately,
Marja J Karttunen +4 more
doaj +1 more source
Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration
Advanced Healthcare Materials, EarlyView.This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu +4 more
wiley +1 more source
Nature CommunicationsMyelin loss induces neural dysfunction and contributes to the pathophysiology of neurodegenerative diseases, injury conditions, and aging. Because remyelination is often incomplete, better understanding endogenous remyelination and developing ...
Gustavo Della-Flora Nunes +19 more
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iScienceSummary: Peripheral viral infection disrupts oligodendrocyte (OL) homeostasis such that endogenous remyelination may be affected. Here, we demonstrate that influenza A virus infection perpetuated a demyelination- and disease-associated OL phenotype ...
Allison Y. Louie +6 more
doaj +1 more source
Biointegrated Battery‐Based Electroceuticals
Advanced Materials, EarlyView.Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou +6 more
wiley +1 more source
Oligodendroglial primary cilium heterogeneity during development and demyelination/remyelination
Frontiers in Cellular Neuroscience, 2022 The primary cilium (PC) has emerged as an indispensable cellular antenna essential for signal transduction of important cell signaling pathways. The rapid acquisition of knowledge about PC biology has raised attention to PC as a therapeutic target in ...
Giada Delfino +22 more
doaj +1 more source
Remyelination in the central nervous system
, 2013 Multiple Sclerosis (MS) is an inflammatory disease which causes areas of demyelination in the Central Nervous System (CNS) and affects only humans. Current therapies for MS are focused on anti-inflammatory treatment, which reduce the occurrence and ...
Zhang, Hui
core +3 more sources
Advanced Science, EarlyView.The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang +11 more
wiley +1 more source
Promoting remyelination in multiple sclerosis. [PDF]
, 2019 The greatest unmet need in multiple sclerosis (MS) are treatments that delay, prevent or reverse progression. One of the most tractable strategies to achieve this is to therapeutically enhance endogenous remyelination; doing so restores nerve conduction ...
core +4 more sources
Central Nervous System Remyelination: Roles of Glia and Innate Immune Cells
Frontiers in Molecular Neuroscience, 2019 In diseases such as multiple sclerosis (MS), inflammation can injure the myelin sheath that surrounds axons, a process known as demyelination. The spontaneous regeneration of myelin, called remyelination, is associated with restoration of function and ...
Charbel S. Baaklini +4 more
doaj +1 more source