Results 71 to 80 of about 26,726 (251)

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

Ageing and remyelination failure in people with multiple sclerosis. [PDF]

One of the most promising strategies to delay, prevent, or reverse disability progression in multiple sclerosis (MS) is enhancing endogenous remyelination.

core   +9 more sources

Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination

Nature Communications
Aging accelerates central nervous system remyelination failure and neurodegeneration. Microglia promote remyelination by phagocytosing myelin debris, but this function is impaired by aging-related CD22 upregulation.
Weixing Yan, Yelin Zhao, Hui Li, Li Hong, Qi Jia, Di Zhu, Dong Xiang, Li Du, Lang Hu, Ruixue Bai, Meizhen Xu, Yangyang Tang, Xinzhu Chen, Yiwei Cao, Wenyu Jia, Siyu Wang, Yuting Liu, Jinfeng Ren, Shuai Pan, Yanbiao Shi, Sijia Gao, Fuxing Dong, Jianhong Shi, Jinghua Li, Kuiyang Zheng, Jing Yang, Shuli Zhao, Hui Wang   +27 more
doaj   +1 more source

Myelin Damage and Repair in Pathologic CNS: Challenges and Prospects

Frontiers in Molecular Neuroscience, 2015
Injury to the central nervous system (CNS) results in oligodendrocyte cell death and progressive demyelination. Demyelinated axons undergo considerable physiological changes and molecular reorganizations that collectively result in axonal dysfunction ...
Arsalan eAlizadeh, Scott M. Dyck, Soheila eKarimi-Abdolrezaee   +2 more
doaj   +1 more source

Zebrafish myelination: a transparent model for remyelination? [PDF]

, 2008
There is currently an unmet need for a therapy that promotes the regenerative process of remyelination in central nervous system diseases, notably multiple sclerosis (MS).
Franklin, Robin, Buckley, Clare, P. Goldsmith, R. J. M. Franklin, C. E. Buckley, Buckley, Clare; id_orcid, Goldsmith, Paul   +6 more
core   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system

Neurobiology of Disease, 2018
Remyelination is an endogenous regenerative process of myelin repair in the central nervous system (CNS) with limited efficacy in demyelinating disorders.
Gemma Llufriu-Dabén, Alex Carrete, Elena Chierto, Jo Mailleux, Emeline Camand, Anne Simon, Tim Vanmierlo, Christiane Rose, Bernadette Allinquant, Jerome J.A. Hendriks, Charbel Massaad, Delphine Meffre, Mehrnaz Jafarian-Tehrani   +12 more
doaj   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Regulation of remyelination in multiple sclerosis

FEBS Letters, 2011
Multiple sclerosis is a common demyelinating disease that worsens over the course of disease, a significant problem in clinical management. Disability in MS is significantly promoted by poor repair and remyelination of lesions. Both oligodendrocyte recruitment and maturation defects are seen as major causes of poor remyelination in MS.
Hanafy, Khalid A., Sloane, Jacob A.
openaire   +2 more sources

Statin therapy inhibits remyelination in the central nervous system [PDF]

, 2009
Remyelination of lesions in the central nervous system contributes to neural repair following clinical relapses in multiple sclerosis. Remyelination is initiated by recruitment and differentiation of oligodendrocyte progenitor cells (OPCs) into ...
Ludwin, Samuel K, Kennedy, Timothy E, Zehntner, Simone P, Miron, Veronique E, Owens, Trevor; id_orcid, Owens, Trevor, Kuhlmann, Tanja, Antel, Jack P, Bedell, Barry J   +8 more
core   +1 more source