Results 71 to 80 of about 34,938 (236)
Myelin Recovery in Multiple Sclerosis: The Challenge of Remyelination
Brain Sciences, 2013 Multiple sclerosis (MS) is the most common demyelinating and an autoimmune disease of the central nervous system characterized by immune-mediated myelin and axonal damage, and chronic axonal loss attributable to the absence of myelin sheaths.
Edward L. Hogan +3 more
doaj +1 more source
The glia response after peripheral nerve injury: A comparison between Schwann cells and olfactory ensheathing cells and their uses for neural regenerative therapies [PDF]
, 2017 The peripheral nervous system (PNS) exhibits a much larger capacity for regeneration than the central nervous system (CNS). One reason for this difference is the difference in glial cell types between the two systems.
Barton, Matthew J. +4 more
core +2 more sources
Promoting remyelination in multiple sclerosis [PDF]
Journal of Neurology, 2019 AbstractThe greatest unmet need in multiple sclerosis (MS) are treatments that delay, prevent or reverse progression. One of the most tractable strategies to achieve this is to therapeutically enhance endogenous remyelination; doing so restores nerve conduction and prevents neurodegeneration.
Cunniffe, Nick, Coles, Alasdair
openaire +3 more sources
Force stimulation promotes nerve regeneration by restoring cellular energy
BMEMat, EarlyView.Mechanical stimulation can help nerves regenerate in various ways. We developed two devices (a piezo‐motor‐driven stretching device and a SAW‐based actuator) to apply mechanical stimulation to sciatic nerve and DRG neurons. Our study shows that appropriate mechanical force stimulation can promote regeneration by restoring the energy supply to the ...
Zhe Wang +10 more
wiley +1 more source
Macrophages Regulate Schwann Cell Maturation after Nerve Injury
Cell Reports, 2018 Summary: Pro-regenerative macrophages are well known for their role in promoting tissue repair; however, their specific roles in promoting regeneration of the injured nerve are not well defined.
Jo Anne Stratton +8 more
doaj +1 more source
Astroglial-axonal interactions during early stages of myelination in mixed cultures using in vitro and ex vivo imaging techniques [PDF]
, 2014 <b>Background</b><p></p> Myelination is a very complex process that requires the cross talk between various neural cell types.
Anderson, Kurt I +4 more
core +2 more sources
Epilepsia Open, EarlyView.Abstract Objective Focal epilepsy is characterized by progressive cortical thinning, particularly within limbic structures; however, whether this atrophy reflects acquired seizure‐induced damage or shared genetic predisposition remains unresolved. Methods We integrated genome‐wide association study (GWAS) summary statistics from the ILAE Consortium ...
Dingyuan Zhang +9 more
wiley +1 more source
Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation. [PDF]
, 2019 Disruption of the blood-brain barrier (BBB) is critical to initiation and perpetuation of disease in multiple sclerosis (MS). We report an interaction between oligodendroglia and vasculature in MS that distinguishes human white matter injury from normal ...
Baranzini, Sergio E +9 more
core
Brain Pathology, EarlyView.Integrated histological and transcriptional profiling of the glioblastoma periphery reveals clinically relevant tumor infiltration beyond MRI‐defined boundaries. MRI‐guided biopsies from contrast‐enhancing (CE), non‐contrast‐enhancing (nCE), edema (E), and radiologically normal (N) regions demonstrate that nCE areas frequently retain neoplastic and ...
Olaya de Dios +18 more
wiley +1 more source
Myelin Damage and Repair in Pathologic CNS: Challenges and Prospects
Frontiers in Molecular Neuroscience, 2015 Injury to the central nervous system (CNS) results in oligodendrocyte cell death and progressive demyelination. Demyelinated axons undergo considerable physiological changes and molecular reorganizations that collectively result in axonal dysfunction ...
Arsalan eAlizadeh +2 more
doaj +1 more source