Results 71 to 80 of about 25,880 (231)

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Fingolimod does not enhance cerebellar remyelination in the cuprizone model [PDF]

, 2015
Fingolimod (FTY720) is approved for treatment of relapsing–remitting multiple sclerosis. In vitro studies have found that fingolimod stimulates remyelination in cerebellar slices, but in vivo animal studies have not detected any positive effect on ...
Vedeler, Christian A., Bø, Lars, Nystad, Agnes E., Myhr, Kjell-Morten, Wergeland, Stig, Alme, Maria Nordheim, Torkildsen, Øivind, Nystad, Agnes Elisabeth   +7 more
core   +1 more source

Innate and adaptive immune mechanisms regulating central nervous system remyelination

, 2022
Neuroinflammation is a hallmark of many neurodegenerative diseases and is considered their underlying cause. However, certain aspects of neuroinflammation favour beneficial outcomes after damage including the regeneration of myelin (remyelination).
Creswell, Richard, Dombrowski, Yvonne; id_orcid   +1 more
core   +1 more source

Remyelination of the injured spinal cord [PDF]

, 2007
Contusive spinal cord injury (SCI) can result in necrosis of the spinal cord, but often long white matter tracts outside of the central necrotic core are demyelinated. One experimental strategy to improve functional outcome following SCI is to transplant myelin-forming cells to remyelinate these axons and improve conduction.
Masanori, Sasaki, Bingcang, Li, Karen L, Lankford, Christine, Radtke, Jeffery D, Kocsis   +4 more
openaire   +2 more sources

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Ageing and remyelination failure in people with multiple sclerosis. [PDF]

One of the most promising strategies to delay, prevent, or reverse disability progression in multiple sclerosis (MS) is enhancing endogenous remyelination.

core   +9 more sources

Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination

Nature Communications
Aging accelerates central nervous system remyelination failure and neurodegeneration. Microglia promote remyelination by phagocytosing myelin debris, but this function is impaired by aging-related CD22 upregulation.
Weixing Yan, Yelin Zhao, Hui Li, Li Hong, Qi Jia, Di Zhu, Dong Xiang, Li Du, Lang Hu, Ruixue Bai, Meizhen Xu, Yangyang Tang, Xinzhu Chen, Yiwei Cao, Wenyu Jia, Siyu Wang, Yuting Liu, Jinfeng Ren, Shuai Pan, Yanbiao Shi, Sijia Gao, Fuxing Dong, Jianhong Shi, Jinghua Li, Kuiyang Zheng, Jing Yang, Shuli Zhao, Hui Wang   +27 more
doaj   +1 more source

Myelin Damage and Repair in Pathologic CNS: Challenges and Prospects

Frontiers in Molecular Neuroscience, 2015
Injury to the central nervous system (CNS) results in oligodendrocyte cell death and progressive demyelination. Demyelinated axons undergo considerable physiological changes and molecular reorganizations that collectively result in axonal dysfunction ...
Arsalan eAlizadeh, Scott M. Dyck, Soheila eKarimi-Abdolrezaee   +2 more
doaj   +1 more source

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis

Remyelination is a crucial regenerative process in demyelinating diseases, limiting persisting damage to the central nervous system (CNS). It restores saltatory nerve conduction and ensures trophic support of axons.
van der Meer, Franziska, Vakrakou, Aigli, Nessler, Stefan, Nau-Gietz, Cora, Bergner, Caroline Gertrud, Lagumersindez-Denis, Nielsen, Würfel, Thea, Schäfer, Lisa, Winkler, Anne, Stadelmann, Christine, Franz, Jonas   +10 more
core   +1 more source