Results 81 to 90 of about 34,938 (236)

FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination. [PDF]

, 2014
BackgroundFTY720 (fingolimod) is the first oral drug approved by the Food and Drug Administration for treatment of patients with the relapsing-remitting form of the human demyelinating disease multiple sclerosis.
Blanc, Caroline A, Lane, Thomas E, Rosen, Hugh   +2 more
core   +1 more source

Electroacupuncture and category IV LASER for treating suprascapular neuropathy in a two‐year‐old Arabian filly

Equine Veterinary Education, EarlyView.
Summary A 2‐year‐old Arabian filly presented with acute onset grade 4/5 (AAEP) right forelimb lameness and hindlimb ataxia following a collision with another horse and subsequent fall. The right forelimb lameness was associated with marked scapulohumeral joint instability.
O. E. Newman, B. Dunkel, M. Perrier
wiley   +1 more source

Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration

npj Regenerative Medicine
Regulation of myeloid cell activity is critical for successful myelin regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis (MS).
Jingwen Hu, George S. Melchor, Dimitrios Ladakis, Joan Reger, Hee Won Kim, Kelly A. Chamberlain, Nataliia V. Shults, Helena C. Oft, Victoria N. Smith, Lauren M. Rosko, Erqiu Li, Maryna Baydyuk, Meng-Meng Fu, Pavan Bhargava, Jeffrey K. Huang   +14 more
doaj   +1 more source

Combination Therapy With Fingolimod and Neural Stem Cells Promotes Functional Myelination [PDF]

, 2019
Myelination, which occurs predominantly postnatally and continues throughout life, is important for proper neurologic function of the mammalian central nervous system (CNS).
Ciric, Bogoljub, Li, Xing, Lu, Xin-Yu, Ma, Cun-Gen, Rostami, A. M., Ye, Ze-Qin, Zhang, Guang-Xian, Zhang, Yuan   +7 more
core   +1 more source

Activity of Cyclic AMP Phosphodiesterases and Adenylyl Cyclase in Peripheral Nerve after Crush and Permanent Transection Injuries [PDF]

, 1998
Recent studies demonstrate that cAMP levels are tightly controlled during demyelination and remyelination in Schwann cells as cAMP decreases to 8–10% of normal following both sciatic nerve crush or permanent transection injury and only begins to increase
Poduslo, Joseph F., Walikonis, Randall S.   +1 more
core   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Relationship between prolactin plasma levels and white matter volume in women with multiple sclerosis [PDF]

, 2015
BACKGROUND: The role of prolactin (PRL) on tissue injury and repair mechanisms in multiple sclerosis (MS) remains unclear. The aim of this work was to investigate the relationship between PRL plasma levels and brain damage as measured by magnetic ...
Barletta, VALERIA TERESA, Contessa, Gian Marco, DE ANGELIS, Floriana, DE GIGLIO, Laura, Gurreri, F., Marinelli, Fabiana, Pantano, Patrizia, Piattella, MARIA CRISTINA, Pozzilli, Carlo, Prosperini, Luca, Tomassini, Valentina   +10 more
core   +4 more sources

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, EarlyView.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source

Remyelination protects neurons from DLK-mediated neurodegeneration

Nature Communications
Chronic demyelination and oligodendrocyte loss deprive neurons of crucial support. It is the degeneration of neurons and their connections that drives progressive disability in demyelinating disease.
Greg J. Duncan, Sam D. Ingram, Katie Emberley, Jo Hill, Christian Cordano, Ahmed Abdelhak, Michael McCane, Jennifer E. Jenks, Nora Jabassini, Kirtana Ananth, Skylar J. Ferrara, Brittany Stedelin, Benjamin Sivyer, Sue A. Aicher, Thomas S. Scanlan, Trent A. Watkins, Anusha Mishra, Jonathan W. Nelson, Ari J. Green, Ben Emery   +19 more
doaj   +1 more source

Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system

Neurobiology of Disease, 2018
Remyelination is an endogenous regenerative process of myelin repair in the central nervous system (CNS) with limited efficacy in demyelinating disorders.
Gemma Llufriu-Dabén, Alex Carrete, Elena Chierto, Jo Mailleux, Emeline Camand, Anne Simon, Tim Vanmierlo, Christiane Rose, Bernadette Allinquant, Jerome J.A. Hendriks, Charbel Massaad, Delphine Meffre, Mehrnaz Jafarian-Tehrani   +12 more
doaj   +1 more source