Results 81 to 90 of about 22,271 (244)
Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim +4 more
wiley +1 more source
Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination
eLifeRevealing unknown cues that regulate oligodendrocyte progenitor cell (OPC) function in remyelination is important to optimise the development of regenerative therapies for multiple sclerosis (MS). Platelets are present in chronic non-remyelinated lesions
Amber R Philp +20 more
doaj +1 more source
In vivo analysis of demyelination and remyelination in an animal model of multiple sclerosis [PDF]
, 2020 Aleksandra Mężydło
openalex +1 more source
Efficacy of Different Intensities of Aquatic Exercises in Remyelination and Neuronal Plasticity Using Cuprizone Model in Male Wistar Rats [PDF]
, 2022 Zareena Begum +5 more
openalex +1 more source
Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression
Archiv der Pharmazie, Volume 359, Issue 6, June 2026.Ion channel remodelling induced by neuroinflammation in multiple sclerosis alters neuronal excitability and immune signalling, creating shared molecular pathways that link multiple sclerosis pathology to depression and reveal novel pharmacological targets.
Nicole Rychlik +4 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.Our findings demonstrate that CYP46A1 plays a critical role in regulating cholesterol homeostasis in microglia and that the targeting of CYP46A1 may offer a viable therapeutic approach for traumatic brain injury (TBI). The CYP46A1 activator Efavirenz reduces white matter damage by increasing the levels of the cholesterol metabolite 24OHC, thereby ...
Lin Li +10 more
wiley +1 more source
EEF1A1 deacetylation enables transcriptional activation of remyelination
Nature Communications, 2020 The molecular mechanisms regulating remyelination are unclear. Here, the authors show that promoting deacetylation of eEF1A1 prevents the translocation of Sox10 outside the nucleus, contributing to maintaining the expression of Sox10 target genes and ...
Mert Duman +14 more
doaj +1 more source
Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong +3 more
wiley +1 more source
Effect of glial cells on remyelination after spinal cord injury
Neural Regeneration Research, 2017 Remyelination plays a key role in functional recovery of axons after spinal cord injury. Glial cells are the most abundant cells in the central nervous system. When spinal cord injury occurs, many glial cells at the lesion site are immediately activated,
Hai-feng Wang +12 more
doaj +1 more source
Remyelination In Multiple Sclerosis
, 2007 Remyelination is the phenomenon by which new myelin sheaths are generated around axons in the adult central nervous system (CNS). This follows the pathological loss of myelin in diseases like multiple sclerosis (MS). Remyelination can restore conduction properties to axons (thereby restoring neurological function) and is increasingly believed to exert ...
openaire +2 more sources