Results 91 to 100 of about 26,726 (251)

Extensive cortical remyelination in patients with chronic multiple sclerosis

, 2007
Recent studies revealed prominent cortical demyelination in patients with chronic multiple sclerosis (MS). Demyelination in white matter lesions is frequently accompanied by remyelination.
Brueck, Wolfgang, Stadelmann, Christine, Albert, Monika, Antel, Jack P.   +3 more
core   +1 more source

Swallowing‐Related Quality of Life After Carotid Body Tumor Resection: A Longitudinal Trajectory Analysis

Head &Neck, EarlyView.
ABSTRACT Objectives To identify longitudinal swallowing‐related QoL trajectories after carotid body tumor (CBT) resection and explore associated characteristics. Methods A prospective study assessed swallowing‐related QoL using the MD Anderson Dysphagia Inventory at nine timepoints from preoperation to 12 months postdischarge.
Pan Chen, Qiao‐Dan Lu, He‐Jing Liang, Ming‐Hua Guo, Jia‐Pin Chen, Chun‐Xu Yang, Guang‐Chao Gu, Lei Wang, Yue‐Hong Zheng   +8 more
wiley   +1 more source

Multi‐Parametric Phase‐Cycled Balanced Steady‐State Free Precession Brain Tissue Characterization in Relapsing‐Remitting Multiple Sclerosis

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Time‐efficient phase‐cycled balanced steady‐state free precession (pc‐bSSFP) imaging is a novel microstructure‐ and myelin‐sensitive approach for multi‐parametric brain tissue characterization not yet evaluated in demyelinating diseases such as multiple sclerosis (MS).
Florian Birk, Benjamin Bender, Hamzeh Tesh, Anagha Deshmane, Maris M. Fabian, Markus C. Kowarik, Tobias Lindig, Ulrike Ernemann, Klaus Scheffler, Rahel Heule   +9 more
wiley   +1 more source

From nature to nanoscale: advances, challenges, and preclinical translation of nanofiber drug delivery systems containing plant‐derived active ingredients

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Since the early 1960s, nanotechnology has been a critical area of science, allowing for the development of sophisticated nanomaterials. Nanofibers, one of the most widely used nanotechnological drug delivery systems, have emerged as a highly versatile platform within modern pharmaceutical sciences.
Heybet Kerem Polat, Yasin Turanlı, Nihat Kurt, Sefa Gözcü, Emre Tunçel, Hilal Bacanak, Eren Aytekin, Sedat Ünal   +7 more
wiley   +1 more source

Steroid-dependent regulation of central nervous system remyelination: From gonadal hormones to chemokine signaling

Neurobiology of Disease
Efficient remyelination in the adult central nervous system remains limited and poorly understood. Recent experimental studies reveal that gonadal steroid hormones are essential regulators of myelin repair and that cooperation between androgen receptor ...
Abdel Mouman Ghoumari, Michael Schumacher   +1 more
doaj   +1 more source

Effect of glial cells on remyelination after spinal cord injury

Neural Regeneration Research, 2017
Remyelination plays a key role in functional recovery of axons after spinal cord injury. Glial cells are the most abundant cells in the central nervous system. When spinal cord injury occurs, many glial cells at the lesion site are immediately activated,
Hai-feng Wang, Xing-kai Liu, Rui Li, Ping Zhang, Ze Chu, Chun-li Wang, Hua-rui Liu, Jun Qi, Guo-yue Lv, Guang-yi Wang, Bin Liu, Yan Li, Yuan-yi Wang   +12 more
doaj   +1 more source

Retinoid X receptor gamma signaling accelerates CNS remyelination [PDF]

, 2010
The molecular basis of CNS myelin regeneration (remyelination) is poorly understood. We generated a comprehensive transcriptional profile of the separate stages of spontaneous remyelination that follow focal demyelination in the rat CNS and found that ...
Krezel, Wojciech, Chambon, Pierre, Huang, Jeffrey K, Christophe Kerninon, Kagechika, Hiroyuki, Julien Bauer, Brahim Nait Oumesmar, Jarjour, Andrew A., Andrew A Jarjour, Jarjour, Andrew A, Bauer, Julien, Pierre Chambon, Zhao, Chao, Ffrench-Constant, Charles, Nait Oumesmar, Brahim, Anne Baron-Van Evercooren, Hiroyuki Kagechika, Robin J M Franklin, Baron-Van Evercooren, Anne, Charles ffrench-Constant, Huang, Jeffrey K., Franklin, Robin J.M., Wojciech Krezel, Anna Williams, Jeffrey K Huang, Franklin, Robin J. M., Oumesmar, Brahim Nait, Chao Zhao, Kerninon, Christophe, Williams, Anna   +29 more
core   +1 more source

Optical Stimulation and Monitoring of the Peripheral Nervous System: Perspectives and Challenges Toward Clinical Translation

Laser &Photonics Reviews, EarlyView.
Optical neuromodulation with IR light allows stimulation of the PNS without the need for physical contact with the target nerve or without requiring any genetic modification. The clinical translation of this technique will pave the way to the development of neural interfaces for restoring sensory feedback in individuals with limb amputation.
Federica Piccirillo, Sarassunta Ucci, Anna Aliberti, Patrizio Vaiano, Alessia La Rocca, Francesca Angelone, Silvia Pascarella, Pellegrino Lippiello, Maria Concetta Miniaci, Giuseppe Prisco, Michela Russo, Francesco Amato, Deyanira Contartese, Milena Fini, Gianluca Giavaresi, Lucia Martini, Francesco Rosa, Cosimo Gentile, Emanuele Gruppioni, Armando Ricciardi, Andrea Cusano   +20 more
wiley   +1 more source

Identification of a microglia phenotype supportive of remyelination

, 2011
In multiple sclerosis, endogenous oligodendrocyte precursor cells (OPCs) attempt to remyelinate areas of myelin damage. During disease progression, however, these attempts fail.
Brouwer, Nieske, Amor, Sandra, Bart Eggen, Nieske Brouwer, VINET, JONATHAN, Jonathan Vinet, Eggen, Bart; id_orcid, Marta Olah, Boddeke, Erik, Eggen, Bart, Sandra Amor, Olah, Marta, Knut Biber, Hendrikus W. G. M. Boddeke, Biber, Knut, Boddeke, Hendrikus W. G. M.   +15 more
core   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source