Results 111 to 120 of about 26,726 (251)

Myelin Maintenance and Addition Regulate Synaptic Plasticity in the Adult Mouse Cortex

Glia, Volume 74, Issue 12, December 2026.
We report that existing myelin allows neurons to remain plastic throughout life, while new myelin progressively stabilises synapses along the basal but not apical dendrites of layer V pyramidal neurons in the motor cortex. ABSTRACT Myelin has the capacity to affect synapse number or plasticity across the lifespan.
Renee E. Pepper, Kalina Makowiecki, Kimberley A. Pitman, Raphael Ricci, Angela L. Nicoli, Phuong Tram Nguyen, Catherine A. Blizzard, Ben Emery, Carlie L. Cullen, Kaylene M. Young   +9 more
wiley   +1 more source

Remyelination After Cuprizone-Induced Demyelination Is Accelerated in Juvenile Mice

, 2015
Remyelination capacity decreases with age in adult mice, but data comparing remyelination capacity after toxic demyelination in developing mice versus adult mice are not available.
Wegner, Christiane, Nessler, Stefan, Brueck, Wolfgang, Pfeifenbring, Sabine, Stadelmann, Christine   +4 more
core   +1 more source

Disruption of Lactate Metabolism in the Peripheral Nervous System Leads to Motor‐Selective Deficits

Glia, Volume 74, Issue 12, December 2026.
To test the importance of lactate metabolism and shuttling between Schwann cells and neurons in the PNS, we selectively knocked out both LDHA and LDHB in motor neurons, sensory neurons, or Schwann cells. ABSTRACT Schwann cells (SCs) myelinate and provide trophic support to axons in the peripheral nervous system (PNS).
A. Joseph Bloom, Shweta Tendulkar, Amber R. Hackett, Amy Strickland, Yurie Sato‐Yamada, Liya Yuan, Wendy Dong, Joseph Ippolito, Robert E. Schmidt, Yo Sasaki, Aaron DiAntonio, Jeffrey Milbrandt   +11 more
wiley   +1 more source

Fampridine for Symptomatic Treatment in Chronic Inflammatory Demyelinating Polyneuropathy: A Randomized, Double‐Blinded, Placebo‐Controlled Crossover Study

Journal of the Peripheral Nervous System, Volume 31, Issue 4, December 2026.
ABSTRACT Background and Aims Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is an immune‐mediated neuropathy that may cause persistent disability despite immunoglobulin treatment. Ion channel dysfunction has been demonstrated in CIDP, but no therapies specifically target this mechanism.
Peter Nørregaard Hansen, Lars Markvardsen, Hatice Tankisi, Henning Andersen, Thomas Krøigård, Søren Sindrup   +5 more
wiley   +1 more source

Mechanisms of Exercise Training in Ameliorating Cognitive Function in Patients With Depression: A Narrative Review of Molecular Targets and Clinical Prescriptions

European Journal of Sport Science, Volume 26, Issue 11, November 2026.
ABSTRACT Depression is frequently accompanied by core cognitive impairments, notably in executive function and memory. Although the ameliorative effects of exercise training have been widely corroborated, the evidence regarding its underlying mechanisms remains fragmented. To provide a comprehensive and integrated view, this review proposes a testable,
Zhaohui Guo, Lingling Dong, Jessie J. X. Lin, Yanping Duan, Weizhi Liu, Wanting Jiang, Cong Liu, Shuqi Jia, Yagang Song, Feng Ding, Zhenwen Xie, Mingyue Yin, Kang Zhu, Xiaochen Ma, Peng Wang, Chen Wei, Felipe Barreto Schuch, Xing Wang   +17 more
wiley   +1 more source

Remyelinating Drugs at a Crossroad: How to Improve Clinical Efficacy and Drug Screenings

Cells
Axons wrapped around the myelin sheath enable fast transmission of neuronal signals in the Central Nervous System (CNS). Unfortunately, myelin can be damaged by injury, viral infection, and inflammatory and neurodegenerative diseases.
Aland Ibrahim Ahmed Al Jaf, Simone Peria, Tommaso Fabiano, Antonella Ragnini-Wilson   +3 more
doaj   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets. [PDF]

MedComm (2020)
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Huang L, Cheng P, Liu G, Xiang Y, Hong Z, Le W.   +5 more
europepmc   +2 more sources

In vitro modeling of central nervous system myelination and remyelination

, 2011
This review aims to summarize the current techniques to study myelination and remyelination in culture systems. We attempt to put these into historical context, and to identify the strengths and weaknesses of each approach, which vary depending on the ...
Zhang, Hui, Anna Williams, Jarjour, Andrew A., ffrench-Constant, Charles, Andrew A. Jarjour, Nina Bauer, Charles ffrench-Constant, Hui Zhang, Bauer, Nina, Williams, Anna   +9 more
core   +1 more source

The Maintenance of Dysmyelinated Small‐Diameter Axons by 14‐3‐3s in the Central Nervous System

Glia, Volume 74, Issue 11, November 2026.
Dysmyelinated small‐diameter axons are maintained in teneurin‐4 deficient mice at the age of 1 year, while axonal damage is observed. 14‐3‐3s are highly expressed and suppress the progression of the damage in these axons. ABSTRACT In the central nervous system, myelin formed around nerve axons by oligodendrocyte enables efficient conduction of action ...
Nanako Yamada, Hinako Saito, Riko Takahashi, Mio Fujisato, Yukina Hosoda, Binri Sasaki, Momona Yamada, Sakurako Abe, Chikako Hayashi, Akira Yoshimoto, Ryunosuke Ohkawa, Tomal Julian Matt, Florence M Bareyre, Stefan Berghoff, Mikael Simons, Nobuharu Suzuki   +15 more
wiley   +1 more source

Progenitor Timing Shapes NG2‐Glia Fate and Oligodendrocyte Differentiation

Glia, Volume 74, Issue 11, November 2026.
Developmental timing defines NG2‐glia and oligodendrocyte fate. E16 NG2‐progenitors produce large, more dispersed NG2‐glia clones. P0 progenitors show a bias toward oligodendrocyte differentiation. Temporal windows establish long‐term cortical glial heterogeneity.
Ana Cristina Ojalvo‐Sanz, Carolina Pernia‐Solanilla, Laura López‐Mascaraque   +2 more
wiley   +1 more source