Results 111 to 120 of about 25,880 (231)

In Transected Nerves, Distal Repair Schwann Cells at the Injury Site Direct and Accelerate Axonal Regrowth

Glia, Volume 74, Issue 10, October 2026.
After nerve transection in larval zebrafish, proximal and distal Schwann cells have distinct functions at the injury site. Distal repair Schwann cells promote axonal regrowth. Axonal regrowth is normal in mutants with only a few macrophages. ABSTRACT In vertebrate peripheral nerves, damaged axons can regrow after injury, but the outcomes of ...
Daniel E. Lysko, Annika R. Johnson, William S. Talbot   +2 more
wiley   +1 more source

Dicer deficiency affects microglial function during demyelination and impairs remyelination

Neurobiology of Disease
Microglia are essential regulators of central nervous system (CNS) homeostasis, playing key roles in demyelination and remyelination. Dysregulated microglial activity contributes to pathological inflammation and impaired repair processes in demyelinating
Ajai Tripathi, Nagendra Kumar Rai, Aaron Perles, Haley Courtney, Claire Jones, Adya Sapra, Jason Plemel, Ranjan Dutta   +7 more
doaj   +1 more source

Decalcified and Decellularized Bone Conduits for Peripheral Nerve Regeneration: A Comparative In Vivo Study Using Rat Femur and Chicken Ulna Conduits

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Purpose: Peripheral nerve injuries (PNIs) pose a major clinical challenge, especially when nerve gaps exceed 5 mm and spontaneous regeneration is inadequate. This study aimed to evaluate the regenerative potential of novel bone‐derived nerve guidance conduits (NGCs) fabricated from rat femoral diaphysis and chicken ulna as alternatives to ...
Zahra Sepehri, Ali Moradi, Nasser Mahdavi‐Shahri, Morteza Behnam Rassouli   +3 more
wiley   +1 more source

Crosstalk Between Cortical Plasticity and Peripheral Nervous Injury: Insights, Mechanisms, and Future Directions

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Peripheral nerve injury induces dynamic cortical plasticity, driven by molecular mechanisms such as BDNF and neurotransmitter systems. This review synthesizes subtype‐specific plasticity patterns: compressive injuries trigger rapid reorganization, while metabolic neuropathies lead to maladaptive changes.
Cong Cheng, Dong Gao, Yaojie Shen, Xi Wang, Junxi Dai, Yaoxian Xiang, Zongyuan Jiang, Zongqi You, Junjian Jiang   +8 more
wiley   +1 more source

Inhibition of METTL14 Alleviates OGD/R‐Induced Neuronal Differentiation Injury in Neural Stem Cells Through Suppressing the Tp53inp2/Ptgs2 Axis: Potential Benefits for the Mouse MCAO Model

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
The graphical abstract highlights that ischemic stroke leads to increased METTL14 expression, which enhances Tp53inp2 mRNA stability through m6A modification. Elevated Tp53inp2 then promotes damaging mitophagy and ROS production by upregulating Ptgs2, ultimately impairing the neuronal differentiation of neural stem cells.
Dan Hou, Yujie Hu, Tian Yun, Dan Yu, Guoshuai Yang   +4 more
wiley   +1 more source

Lcn2 Promotes Ferroptosis in Intracerebral Hemorrhage by Targeting Keap1 Tyr572 and Restricting Nrf2 Activation

MedComm, Volume 7, Issue 9, September 2026.
This study reveals that Lcn2 regulates ferroptosis after ICH via the Keap1/Nrf2 axis. Neuronal Lcn2 deletion reduces lipid peroxidation, restores mitochondrial function, and improves ferroptosis. Keap1 Tyr572Ala mutant acts as a molecular switch whose effects invert with Lcn2 status.
Ya‐nan Dou, Hongkang Hu, Qinghua Li, Guangming Wang, Lijun Hou, Junbin Liu, Buyi Zheng, Ying Li, Guohan Hu, Zhou Fei, Xia Li, Li Wang, Jialiang Wei, Lei Jiang, Xiaowei Fei   +14 more
wiley   +1 more source

Remyelinating Drugs at a Crossroad: How to Improve Clinical Efficacy and Drug Screenings

Cells
Axons wrapped around the myelin sheath enable fast transmission of neuronal signals in the Central Nervous System (CNS). Unfortunately, myelin can be damaged by injury, viral infection, and inflammatory and neurodegenerative diseases.
Aland Ibrahim Ahmed Al Jaf, Simone Peria, Tommaso Fabiano, Antonella Ragnini-Wilson   +3 more
doaj   +1 more source

Dietary Intervention With Lutein, Docosahexaenoic Acid, and Choline During Early Development Improves Recognition Memory in Young Adult Females in an Experimental Model

Molecular Nutrition &Food Research, Volume 70, Issue 17, 15 September 2026.
Our study investigates the effects of perinatal supplementation with lutein, DHA, and choline in a controlled rat model. The results show: (1) strictly sex‐specific effects exclusively observed in female rats, (2) lutein‐dependent and synergistic effects, (3) enhancement of long‐term recognition memory, and (4) no effects on locomotor activity, anxiety‐
Leon Saschin, Gregor Fink, Maria Wohlfarth, Jonas Hauser, Jian Yan, Dirk Wiedermann, Mathias Hoehn, Jochen Wilhelm, Lea Quell, Elisabeth Sous, Jenny Voggel, Jörg Dötsch, Eva Nüsken, Kai‐Dietrich Nüsken   +13 more
wiley   +1 more source

Evaluating the Influence of Injury‐Induced Microstructural Variations on the Efficacy of a Diffusion MRI‐Derived Axon Diameter Surrogate

Magnetic Resonance in Medicine, Volume 96, Issue 3, Page 1355-1364, September 2026.
ABSTRACT Purpose To investigate the utility of a recently demonstrated diffusion MRI derived axon diameter surrogate measure (∆D⟂) under pathologic conditions induced by a spinal cord injury model. Methods Contusion injuries were performed on the thoracic–lumbar spinal cord of adult male rats.
Hannah E. Alderson, Chaoqi Mu, Li Min Chen, Mark D. Does, Kevin D. Harkins   +4 more
wiley   +1 more source

Administration of Schwann Cell‐Like Cells Differentiated From Tonsil‐Derived Mesenchymal Stem Cells Promotes Peripheral Nerve Regeneration by Inducing Macrophage Polarization in a Chronic Constriction Injury Model

Muscle &Nerve, Volume 74, Issue 3, Page 728-739, September 2026.
TMSC‐SCs were mixed with fibrin adhesive and administered into the sciatic nerve of CCI rats, and nerve conduction studies and histopathological observations confirmed the regeneration of the peripheral nerve and gastrocnemius muscle. In addition, the expression of M1 and M2 macrophage markers was observed after the administration of TMSC‐SCs. ABSTRACT
Yu Hwa Nam, Ji‐Sup Kim, Yoonji Yum, Juhee Yoon, Youbeen Cho, Jaeseung Lim, Saeyoung Park, Sung‐Chul Jung   +7 more
wiley   +1 more source