Results 121 to 130 of about 26,726 (251)

Betaine Attenuates Cuprizone‐Induced Cortical Demyelination: The Role of the WNT4/mTOR Signalling Pathway in Regulating Astrogliosis and Synaptic Integrity

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Betaine helps to restore the dysfunctional communication between oxidative stress and inflammation, and it also improves demyelination in cuprizone‐induced demyelinating disease within the cerebral cortex. ABSTRACT Cortical grey matter pathology manifests early demyelinating diseases and is a primary driver of permanent neurological impairment.
Yara M. Said, Heba‐Tallah Abd Elrahim Abd Elkader, Gihad Jamal Bekheet, Sherine Abdel Salam, Amina E. Essawy   +4 more
wiley   +1 more source

The Role of Astrocytes in the Inflammatory Response in Neurodiseases

MedComm, Volume 7, Issue 11, November 2026.
Reactive astrocyte‐mediated pathogenic mechanisms in neurodegenerative diseases Schematic representation of key astrocytic pathways contributing to pathology in the pathogenesis of AD, PD, ALS, and HD. In AD, astrocytes exhibit Aβ plaque‐associated activation characterized by GFAP/S100β upregulation, accompanied by impaired EAAT2‐mediated glutamate ...
Shijun Peng, Lepeng Wang, Jia Ouyang, Ruen Liu   +3 more
wiley   +1 more source

Pilot functional magnetic resonance imaging study of clemastine‐aided functional recovery on a mouse model of demyelination

Neuroprotection
Background Multiple sclerosis (MS) is a chronic demyelinating disease characterized by autoimmune attacks on myelin sheaths. Its deleterious effects may be reversed by remyelination, a process that restores the integrity of myelin sheaths and ...
Ander Egimendia, Irati L. de laPisa, Daniel Padro, Lorena Colás, Sandra Plaza‐García, David Otaegui, Pedro Ramos‐Cabrer   +6 more
doaj   +1 more source

Manipulating developmental mechanisms to promote remyelination [PDF]

, 2012
Remyelination, the ability of oligodendrocytes to extend myelin sheaths to wrap demyelinated axons, becomes progressively inefficient and can fail in multiple sclerosis (MS) leading to axonal degeneration and permanent functional deficits.
Harrington, Emily Prentiss
core  

Isobaric Incorporation of C13-Histidine for the Assessment of Remyelination

, 2022
Multiple sclerosis is a demyelinating disease of the central nervous system characterized by the loss of the myelin sheath-the nonconductive membrane surrounding neuronal axons.
Valdivia, Anddre Osmar, Harvey, Faith Christine, Hayter, Colin, Bhattacharya, Sanjoy K   +3 more
core  

Neurodegenerative Diseases: Epidemiology, Risk Factors, Classification, Pathophysiology, Clinical Features, Diagnosis, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He, Jingjing Zeng, Guoqing Wang, Yuxin Li, Feng Zhang   +4 more
wiley   +1 more source

Multiple Sclerosis and Viruses: « Liaisons Dangereuses »

Reviews in Medical Virology, Volume 36, Issue 6, November 2026.
ABSTRACT Multiple sclerosis (MS) is a complex, multifactorial neurodegenerative disease with an aetiology that is still partially elusive. Several risk factors are associated with MS development including genetic predisposition and various environmental stressors; however, recently, viral infections have gained significant attention as a crucial ...
Samanta Plavina, Daniela Malakovska, Jolanta Kalnina, Ilva Trapina, Elina Leonova, Mohammed Habib, Susanne Schifmann, Jegors Paramonovs, Nikolajs Sjakste, Yegor Vassetzky, Emmanuel Drouet, Natalia Paramonova   +11 more
wiley   +1 more source

Microenvironmental Regulation of Central Nervous System Myelination and Remyelination

Journal of Integrative Neuroscience
Both myelination and remyelination in the central nervous system (CNS) rely on the differentiation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes (OLs).
Yuxuan Wang, Lingzhen Tan, Lin Lao, Xiaomeng Huang, Sheng Zhang, Haitao Sun   +5 more
doaj   +1 more source

In Vivo Partial Cell Reprogramming With Yamanaka Factors Reduced Ischemic Brain Damage in Aging Mice

Aging Cell, Volume 25, Issue 11, November 2026.
Short‐term cyclic partial reprogramming with Yamanaka factors protects aged mice from ischemic brain injury, preserving cognitive function, myelin integrity, and neuronal density, supporting partial reprogramming as a promising neuroprotective intervention in aging.
Paula R. Mallavibarrena, Gerardo Martín‐López, Jorge Rodríguez‐Morales, Jesús Ávila, Félix Hernández, María José Pérez‐Álvarez   +5 more
wiley   +1 more source

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease

Aging Cell, Volume 25, Issue 11, November 2026.
This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang, Huawen Cao, Xiumin Ren, Nan Sha, Xueqing Han, Ling Jiang, Bin Liu, Weiming Zhao   +7 more
wiley   +1 more source