Results 121 to 130 of about 25,880 (231)
NeuroprotectionBackground Multiple sclerosis (MS) is a chronic demyelinating disease characterized by autoimmune attacks on myelin sheaths. Its deleterious effects may be reversed by remyelination, a process that restores the integrity of myelin sheaths and ...
Ander Egimendia +6 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan +3 more
wiley +1 more source
Equine Veterinary Education, Volume 38, Issue 9, Page e614-e621, September 2026.Summary A 2‐year‐old Arabian filly presented with acute onset grade 4/5 (AAEP) right forelimb lameness and hindlimb ataxia following a collision with another horse and subsequent fall. The right forelimb lameness was associated with marked scapulohumeral joint instability.
O. E. Newman, B. Dunkel, M. Perrier
wiley +1 more source
Remyelination capacity of the MS brain decreases with disease chronicity
, 2009 Objective: To analyze and compare the extent of remyelination in lesions from patients with multiple sclerosis (MS) who have a short (early MS lesions) or a long (chronic MS lesions) disease duration and to determine the influence of anatomic ...
Goldschmidt, Thomas +4 more
core +1 more source
Microenvironmental Regulation of Central Nervous System Myelination and Remyelination
Journal of Integrative NeuroscienceBoth myelination and remyelination in the central nervous system (CNS) rely on the differentiation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes (OLs).
Yuxuan Wang +5 more
doaj +1 more source
The Therapeutic Potential of Purmorphamine Across Disease Models
Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.ABSTRACT Purmorphamine (PUR) is a trisubstituted purine compound that selectively activates Smoothened receptor, thereby initiating Sonic Hedgehog (Shh) signalling—a pathway critical for embryonic patterning, neuronal specification and tissue regeneration across multiple organ systems. Dysregulation of Shh signalling has been implicated in degenerative
Ashis Dhar +4 more
wiley +1 more source
Extensive cortical remyelination in patients with chronic multiple sclerosis
, 2007 Recent studies revealed prominent cortical demyelination in patients with chronic multiple sclerosis (MS). Demyelination in white matter lesions is frequently accompanied by remyelination.
Brueck, Wolfgang +3 more
core +1 more source
Remyelination in the CNS: from biology to therapy
, 2008 Remyelination involves reinvesting demyelinated axons with new myelin sheaths. In stark contrast to the situation that follows loss of neurons or axonal damage, remyelination in the CNS can be a highly effective regenerative process.
Franklin, Robin J.M. +3 more
core +1 more source
Targeting progressive multiple sclerosis: Toward mechanism‐informed precision medicine
Journal of Internal Medicine, Volume 300, Issue 3, Page 238-257, September 2026.Abstract Multiple sclerosis has undergone a therapeutic revolution over the past three decades. Randomized clinical trials and real‐world data demonstrate that modern disease‐modifying therapies substantially reduce relapse rates and acute inflammatory activity detected by magnetic resonance imaging (MRI).
Fredrik Piehl +3 more
wiley +1 more source
Remyelination in the Central Nervous System
The inability of the mammalian central nervous system (CNS) to undergo spontaneous regeneration has long been regarded as a central tenet of neurobiology.
Franklin, Robin J.M. +2 more
core +1 more source