Results 121 to 130 of about 34,938 (236)

Senescent-like microglia limit remyelination through the senescence associated secretory phenotype

Nature Communications
The capacity to regenerate myelin in the central nervous system diminishes with age. This decline is particularly evident in multiple sclerosis (MS), a chronic demyelinating disease.
Phillip S. Gross, Violeta Durán-Laforet, Lana T. Ho, George S. Melchor, Sameera Zia, Zeeba Manavi, William E. Barclay, Sung Hyun Lee, Nataliia Shults, Sean Selva, Enrique Alvarez, Jason R. Plemel, Meng-meng Fu, Dorothy P. Schafer, Jeffrey K. Huang   +14 more
doaj   +1 more source

Combination therapy dramatically promotes remyelination

Journal of Molecular Cell Biology
Abstract Multiple sclerosis (MS) is an immune-mediated disease in the central nervous system that is characterized by demyelination, axonal degeneration, and progressive neurological disability and is so far incurable. Current medications are predominantly immune-targeted but fail to prevent disease progression due to their inability ...
Yawen Li, Pingping Li, Yixuan Song, Wenjun Zhang, Xinyue Jiang, Siyi Chen, Wei Luo, Caiyun Ma, Changqing Liu, Jianguo Niu, Aibin Liang, Yarui Du, Bo O Zhou, Mingliang Zhang   +13 more
openaire   +3 more sources

Demyelinating Leprosy Neuropathy: An Unusual and Misleading Electrophysiological Pattern

Muscle &Nerve, Volume 73, Issue 5, Page 898-905, May 2026.
ABSTRACT Introduction/Aims Peripheral neuropathy, especially mononeuropathy multiplex, is a frequent manifestation of leprosy. Electrodiagnostic studies (EDX) usually show predominant axonal involvement. In this study, we report patients with prominent demyelinating abnormalities consistent with the diagnosis of chronic inflammatory demyelinating ...
Cendrine Foucard, Marie Jachiet, Karine Viala, Thierry Maisonobe, Guillaume Fargeot   +4 more
wiley   +1 more source

Systemic TLR2 tolerance enhances central nervous system remyelination

Journal of Neuroinflammation, 2019
Background Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by both inflammatory demyelination and impaired remyelination.
Nicholas J. Wasko, Meghan Horne Kulak, Debayon Paul, Alexandra M. Nicaise, Stephen T. Yeung, Frank C. Nichols, Kamal M. Khanna, Stephen Crocker, Joel S. Pachter, Robert B. Clark   +9 more
doaj   +1 more source

Recent Advances in the Synthesis and Processing of Carbon Nanotubes and Carbon Nanocomposites for Energy Storage, Biomedical, and Environmental Applications

ChemistryOpen, Volume 15, Issue 5, May 2026.
This review summarizes recent advances in the synthesis and processing of carbon nanotubes and carbon nanocomposites, highlighting structure–property relationships and their applications in energy storage, biomedical systems, and environmental technologies, with emphasis on performance optimization and sustainable material design.
Noor‐ul‐Huda Altaf, Muhammad Ayyaz, Yaning Zhang, Mudassar Shahzad, Ayesha Khan, Sanam, Wasqa Liaqat, Ambreen Ashar, Roshaan Malik, Zeeshan Ahmad Bhutta   +9 more
wiley   +1 more source

Dynamic response of microglia/macrophage polarization following demyelination in mice

Journal of Neuroinflammation, 2019
Background The glial response in multiple sclerosis (MS), especially for recruitment and differentiation of oligodendrocyte progenitor cells (OPCs), predicts the success of remyelination of MS plaques and return of function.
Tianci Chu, Yi Ping Zhang, Zhisen Tian, Chuyuan Ye, Mingming Zhu, Lisa B. E. Shields, Maiying Kong, Gregory N. Barnes, Christopher B. Shields, Jun Cai   +9 more
doaj   +1 more source

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Dicer deficiency affects microglial function during demyelination and impairs remyelination

Neurobiology of Disease
Microglia are essential regulators of central nervous system (CNS) homeostasis, playing key roles in demyelination and remyelination. Dysregulated microglial activity contributes to pathological inflammation and impaired repair processes in demyelinating
Ajai Tripathi, Nagendra Kumar Rai, Aaron Perles, Haley Courtney, Claire Jones, Adya Sapra, Jason Plemel, Ranjan Dutta   +7 more
doaj   +1 more source

Temporal and partial inhibition of GLI1 in neural stem cells (NSCs) results in the early maturation of NSC derived oligodendrocytes in vitro. [PDF]

, 2019
BackgroundOligodendrocytes are a type of glial cells that synthesize the myelin sheath around the axons and are critical for the nerve conduction in the CNS.
Biswas, Sangita, Chechneva, Olga, Deng, Wenbin, Mayrhofer, Florian, Namchaiw, Poommaree, Wen, Han   +5 more
core  

Remyelinating Drugs at a Crossroad: How to Improve Clinical Efficacy and Drug Screenings

Cells
Axons wrapped around the myelin sheath enable fast transmission of neuronal signals in the Central Nervous System (CNS). Unfortunately, myelin can be damaged by injury, viral infection, and inflammatory and neurodegenerative diseases.
Aland Ibrahim Ahmed Al Jaf, Simone Peria, Tommaso Fabiano, Antonella Ragnini-Wilson   +3 more
doaj   +1 more source