Oligodendrocyte calcium signaling promotes actin-dependent myelin sheath extension [PDF]
Nature CommunicationsMyelin is essential for rapid nerve signaling and is increasingly found to play important roles in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as sheath length are thought to precisely tune conduction velocity ...
Manasi Iyer +12 more
doaj +5 more sources
Myelin sheath structure and regeneration in peripheral nerve injury repair [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Afferent and efferent nerve fibers cannot be distinguished based on the axonal diameter or the presence of the Remark bundle. The compaction of the myelin sheath involves 2 steps: 1) The distance between the 2 layers of cell membranes in the
Huan-Huan Li, Ting Li, Dan Wang
exaly +5 more sources
Myelinating Schwann Cell Polarity and Mechanically-Driven Myelin Sheath Elongation
Frontiers in Cellular Neuroscience, 2018 Myelin sheath geometry, encompassing myelin sheath thickness relative to internodal length, is critical to optimize nerve conduction velocity and these parameters are carefully adjusted by the myelinating cells in mammals.
Nicolas Tricaud
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Peripheral Nerve Diffusion Tensor Imaging: Assessment of Axon and Myelin Sheath Integrity [PDF]
PLoS ONE, 2015 To investigate the potential of diffusion tensor imaging (DTI) parameters as in-vivo biomarkers of axon and myelin sheath integrity of the median nerve in the carpal tunnel as validated by correlation with electrophysiology.MRI examinations at 3T ...
Maurice Ruetters +2 more
exaly +4 more sources
Oligodendrocyte HCN2 Channels Regulate Myelin Sheath Length. [PDF]
J Neurosci, 2021 Oligodendrocytes generate myelin sheaths vital for the formation, health, and function of the CNS. Myelin sheath length is a key property that determines axonal conduction velocity and is known to be variable across the CNS.
Swire M +5 more
europepmc +6 more sources
Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death. [PDF]
Cell Rep, 2022 SUMMARY Although macroautophagy deficits are implicated across adult-onset neurodegenerative diseases, we understand little about how the discrete, highly evolved cell types of the central nervous system use macroautophagy to maintain homeostasis.
Aber ER +9 more
europepmc +4 more sources
Myelin sheath injury and repairment after subarachnoid hemorrhage [PDF]
Frontiers in Pharmacology, 2023 Subarachnoid hemorrhage (SAH) can lead to damage to the myelin sheath in white matter. Through classification and analysis of relevant research results, the discussion in this paper provides a deeper understanding of the spatiotemporal change ...
Yujie Chen, Peiwen Guo, Xufang Ru
exaly +4 more sources
Treadmilling Model for Plasticity of the Myelin Sheath. [PDF]
Trends Neurosci, 2019 We propose a mechanism for myelin plasticity that would complement synaptic plasticity by adjusting conduction velocity for optimal spike-time arrival. In the proposed treadmilling model, myelin sheath thickness is a dynamic balance between the rates of ...
Fields RD, Dutta DJ.
europepmc +5 more sources
The Akt-mTOR Pathway Drives Myelin Sheath Growth by Regulating Cap-Dependent Translation. [PDF]
J Neurosci, 2021 In the vertebrate CNS, oligodendrocytes produce myelin, a specialized membrane, to insulate and support axons. Individual oligodendrocytes wrap multiple axons with myelin sheaths of variable lengths and thicknesses.
Fedder-Semmes KN, Appel B.
europepmc +2 more sources
The RNA binding protein fragile X mental retardation protein promotes myelin sheath growth. [PDF]
Glia, 2020 During development, oligodendrocytes in the central nervous system extend a multitude of processes that wrap axons with myelin. The highly polarized oligodendrocytes generate myelin sheaths on many different axons, which are far removed from the cell ...
Doll CA, Yergert KM, Appel BH.
europepmc +2 more sources