Myelin sheath structure and regeneration in peripheral nerve injury repair [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Observing the structure and regeneration of the myelin sheath in peripheral nerves following injury and during repair would help in understanding the pathogenesis and treatment of neurological diseases caused by an abnormal myelin sheath.
Bin Liu, Ting Li, Dan Wang
exaly +4 more sources
Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, plasticity, and density of resident glial cells [PDF]
GliaMyelin basic protein (Mbp) is essential for both elaboration and maintenance of CNS myelin, and its reduced accumulation results in hypomyelination. How different Mbp mRNA levels affect myelin dimensions across the lifespan and how resident glial cells ...
Hooman Bagheri +2 more
exaly +6 more sources
A Nanoscale Model System for the Human Myelin Sheath [PDF]
Biomacromolecules, 2021 Neurodegenerative disorders are among the most common diseases in modern society. However, the molecular bases of diseases such as multiple sclerosis or Charcot-Marie-Tooth disease remain far from being fully understood. Research in this field is limited by the complex nature of native myelin and by difficulties in obtaining good in vitro model systems
Matthias Hoffmann +11 more
openaire +4 more sources
Treadmilling Model for Plasticity of the Myelin Sheath. [PDF]
Trends Neurosci, 2019 We propose a mechanism for myelin plasticity that would complement synaptic plasticity by adjusting conduction velocity for optimal spike-time arrival. In the proposed treadmilling model, myelin sheath thickness is a dynamic balance between the rates of new myelin deposited adjacent to the axon and removal of the outermost layer.
Fields RD, Dutta DJ.
europepmc +4 more sources
Oligodendrocyte HCN2 Channels Regulate Myelin Sheath Length. [PDF]
J Neurosci, 2021 Oligodendrocytes generate myelin sheaths vital for the formation, health and function of the central nervous system (CNS). Myelin sheath length is a key property that determines axonal conduction velocity and is known to be variable across the CNS ...
Swire M +5 more
europepmc +4 more sources
Myelin sheath injury and repairment after subarachnoid hemorrhage [PDF]
Frontiers in Pharmacology, 2023 Peiwen Guo, Xufang Ru, Yujie Chen
exaly +2 more sources
Entangled biphoton generation in the myelin sheath
Physical Review EConsciousness within the brain hinges on the synchronized activities of millions of neurons, but the mechanism responsible for orchestrating such synchronization remains elusive. In this study, we employ cavity quantum electrodynamics (cQED) to explore entangled biphoton generation through cascade emission in the vibration spectrum of C-H bonds within ...
Zefei Liu, Yong-Cong Chen, Ping Ao
openaire +4 more sources
Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death. [PDF]
Cell Rep, 2022 Although macroautophagy deficits are implicated across adult-onset neurodegenerative diseases, we understand little about how the discrete, highly evolved cell types of the central nervous system use macroautophagy to maintain homeostasis.
Aber ER +9 more
europepmc +2 more sources
Activity-driven myelin sheath growth is mediated by mGluR5. [PDF]
Nat NeurosciMyelination by oligodendrocytes in the central nervous system is influenced by neuronal activity, but the molecular mechanisms by which this occurs have remained unclear.
Braaker PN +13 more
europepmc +2 more sources
Oligodendrocyte calcium signaling promotes actin-dependent myelin sheath extension. [PDF]
Nat CommunMyelin is essential for rapid nerve signaling and is increasingly found to play important roles in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as sheath length are thought to precisely tune conduction velocity ...
Iyer M +12 more
europepmc +2 more sources