Results 41 to 50 of about 36,787 (207)

A diffusion MRI model for random walks confined on cylindrical surfaces: towards non-invasive quantification of myelin sheath radius [PDF]

Introduction: Quantifying the myelin sheath radius of myelinated axons in vivo is important for understanding, diagnosing, and monitoring various neurological disorders.
Thiran, Jean-Philippe, Rafael-Patiño, Jonathan, Jones, Derek K., Canales-Rodríguez, Erick J., Fischi-Gomez, Elda, Tax, Chantal M. W.   +5 more
core   +2 more sources

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Investigating mechanisms of myelin sheath length regulation and plasticity [PDF]

, 2019
Myelination of axons is important for proper functioning of the nervous system and breakdown of myelin can cause severe disabilities. By regulating nerve conduction, myelination is also critical for learning and memory processes.
Auer, Franziska
core  

Dexmedetomidine infusions improve cardiovascular and renal function in anaesthetised, experimentally endotoxaemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Dexmedetomidine infusions are beneficial in anaesthetised endotoxaemic horses when administered concurrent to endotoxin, but post‐conditioning effects are unknown. Objectives To evaluate whether a dexmedetomidine infusion is beneficial in horses administered Escherichia coli O55:B5 lipopolysaccharides (LPS) endotoxin prior to ...
Sera Lee, Rachel C. Hector, Lynn Pezzanite, Eric Gilleland, Marlis L. Rezende   +4 more
wiley   +1 more source

The pathology of neuropathies with focal thickening of the myelin sheath (tomaculous neuropathy): Studies on the formation of the abnormal myelin sheath

, 1975
The sural nerves of 4 patients showed similar pathological features of sausage-shaped thickenings of the myelin sheaths ranging in length from 80 to 250 μm, of up to 27 μm diameter and affecting fibres of all sizes.
Madrid, R, Bradley, W.G
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Research progress on the use of the optical coherence tomography system for the diagnosis and treatment of central nervous system tumors

Ibrain, Volume 11, Issue 1, Page 3-18, Spring 2025.
With the advantages of high‐resolution imaging, efficient image acquisition, intraoperative real‐time detection, and radiation‐free and noninvasive characteristics, optical coherence tomography (OCT) provides accurate diagnosis and effective intraoperative guidance for the minimally invasive diagnosis and treatment of central nervous system (CNS ...
Jiuhong Li, Ziba Ayi, Gonggong Lu, Haibo Rao, Feilong Yang, Jing Li, Jiachen Sun, Junlin Lu, Xulin Hu, Si Zhang, Xuhui Hui   +10 more
wiley   +1 more source

Somatosensory Disturbance and Long‐Term Exposure to Methylmercury: A Comprehensive Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Chronic exposure to methylmercury remains a significant public health concern, particularly in populations with high fish consumption. Somatosensory disturbances are among the most frequently reported neurological manifestations, even at exposure levels below internationally established safety thresholds. This review aims to synthesize current
Leonardo Breno do Nascimento de Aviz, Carolina Fonte de Aviz, Fabiana Costa Cardoso, Laura dos Santos Barros, Raphaely Cristiny Sanches Progênio, Mariângela Moreno Domingues, José Maria Farah Costa Júnior, Saul Rassy Carneiro, Carlos Araújo da Costa, Maria da Conceição Nascimento Pinheiro   +9 more
wiley   +1 more source

Protective Effects of Imeglimin Against Oxaliplatin‐Induced Peripheral Neurotoxicity: Evidence From In Vitro and In Vivo Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Oxaliplatin is a platinum‐based anticancer agent widely used for gastrointestinal malignancies; however, it is known to cause dose‐dependent peripheral neuropathy (OIPN), a characteristic adverse effect. OIPN results in a reduced quality of life and often necessitates dose reduction or discontinuation of oxaliplatin; however, effective ...
Yusuke Koura, Kano Kinjo, Keisuke Mine, Yusuke Mori, Mami Ueda, Risa Kaneko, Yuna Kamiya, Taiga Sonoda, Haruka Mimata, Shunsuke Fujita, Takehiro Kawashiri, Daisuke Kobayashi   +11 more
wiley   +1 more source

Functional Expression of Electron Transport Chain and FoF1-ATP Synthase in Optic Nerve Myelin Sheath.

, 2015
Our previous studies reported evidence for aerobic ATP synthesis by myelin from both bovine brainstem and rat sciatic nerve. Considering that the optic nerve displays a high oxygen demand, here we evaluated the expression and activity of the five ...
FERRANDO, SARA, BARTOLUCCI, MARTINA, RAVERA, SILVIA, CALZIA, DANIELA, GARBARINO, GRETA, PANFOLI, ISABELLA, RAMOINO, PAOLA, CANDIANI, SIMONA, MORELLI, ALESSANDRO   +8 more
core   +1 more source