Results 21 to 30 of about 53,780 (245)
Loss of ABCA8B decreases myelination by reducing oligodendrocyte precursor cells in mice
Journal of Lipid Research, 2022 The myelin sheath, which is wrapped around axons, is a lipid-enriched structure produced by mature oligodendrocytes. Disruption of the myelin sheath is observed in several neurological diseases, such as multiple sclerosis.
Yiran Liu +14 more
doaj +1 more source
A Jones matrix formalism for simulating three-dimensional polarized light imaging of brain tissue [PDF]
, 2015 The neuroimaging technique three-dimensional polarized light imaging (3D-PLI) provides a high-resolution reconstruction of nerve fibres in human post-mortem brains.
Amunts, Katrin +5 more
core +4 more sources
Optimization of electron microscopy for human brains with long-term fixation and fixed-frozen sections. [PDF]
, 2014 BackgroundAbnormal connectivity across brain regions underlies many neurological disorders including multiple sclerosis, schizophrenia and autism, possibly due to atypical axonal organization within white matter.
Liu, Xiao-Bo, Schumann, Cynthia M
core +1 more source
Microtubules, Myelin Sheaths, and Altered Behavior [PDF]
eneuro, 2021 Mice are skttish creatures that innately hide from perceived threats by staying out of open areas, freezing to avoid predators, or hiding in dark spaces when an adverse stimulus is sensed. However, after inducing a global TPPP (tubulin polymerization promoting protein) gene knock-out (KO), which results in reduced myelin length and thickness (Fu et al.,
openaire +2 more sources
Frontiers in Neurology, 2018 Myelin sensitive MRI techniques, such as diffusion tensor imaging and myelin water imaging, have previously been used to reveal changes in myelin after sports-related concussions.
Alexander M. Weber +14 more
doaj +1 more source
Citrullination – small change with a great consequence [PDF]
, 2013 Citrullination is one of the possible post-translational modifications of proteins. It is based on a conversion of L-arginine residue (L-Arg) to L-citrulline residue (L-Cit). The reaction is catalyzed by peptidylarginine deiminases (PAD). The change of L-
Gogól Mariusz
core +2 more sources
Image Analysis and Stereology, 2017 Studies have provided qualitative evidence of de-myelination and re-myelination in aged brain white matter. However, there have been no quantitative evidences of degeneration and regeneration of myelin sheaths in white matter.
Chen Li +4 more
doaj +1 more source
Myelin pathology: Involvement of molecular chaperones and the promise of chaperonotherapy [PDF]
, 2019 The process of axon myelination involves various proteins including molecular chaperones. Myelin alteration is a common feature in neurological diseases due to structural and functional abnormalities of one or more myelin proteins.
Cappello F. +4 more
core +1 more source
C1q is essential for myelination in the central nervous system (CNS)
iScience, 2023 Summary: Myelin sheath in the central nervous system (CNS) is essential for efficient action potential conduction. Microglia, the macrophages in the CNS, are suggested to regulate myelin development.
Qiang Yu +6 more
doaj +1 more source
Oligodendrocytes express synaptic proteins that modulate myelin sheath formation. [PDF]
Nat Commun, 2019 Hughes AN, Appel B.
europepmc +2 more sources