Results 21 to 30 of about 36,787 (207)
Microtubules, Myelin Sheaths, and Altered Behavior [PDF]
eneuro, 2021 Mice are skttish creatures that innately hide from perceived threats by staying out of open areas, freezing to avoid predators, or hiding in dark spaces when an adverse stimulus is sensed. However, after inducing a global TPPP (tubulin polymerization promoting protein) gene knock-out (KO), which results in reduced myelin length and thickness (Fu et al.,
openaire +2 more sources
Role of Connexin-Based Gap Junction Channels in Communication of Myelin Sheath in Schwann Cells. [PDF]
Front Cell Neurosci, 2019 Peripheral nerves have the capacity to conduct action potentials along great distances and quickly recover following damage which is mainly due to Schwann cells (SCs), the most abundant glial cells of the peripheral nervous system (PNS).
Cisterna BA, Arroyo P, Puebla C.
europepmc +3 more sources
The septin cytoskeleton is associated with distinct myelin structures of the central and peripheral nervous system [PDF]
, 2008 Rapid conduction of nerve impulses in the nervous system of higher vertebrates is made possible by ensheathment of nerve fibers by the specialized plasma membrane structure myelin. Consequently, failure of myelination or damage to the myelin sheath leads
Buser, Andres
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Oligodendrocyte Neurofascin independently regulates both myelin targeting and sheath growth in the CNS [PDF]
, 2019 Selection of the correct targets for myelination and regulation of myelin sheath growth are essential for central nervous system (CNS) formation and function.
Benito-Kwiecinski, SK +21 more
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T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ±
Sarah J. Wright +10 more
wiley +1 more source
Shielding effects of myelin sheath on axolemma depolarization under transverse electric field stimulation. [PDF]
PeerJ, 2018 Axonal stimulation with electric currents is an effective method for controlling neural activity. An electric field parallel to the axon is widely accepted as the predominant component in the activation of an axon.
Ye H, Ng J.
europepmc +2 more sources
Myelin-like sheaths in copepod axons [PDF]
Nature, 1999 Copepods, the small planktonic crustaceans that are the most abundant metazoans in the oceans, are so successful partly because they have an escape response that accelerates them to 200 body lengths per second within milliseconds1,3. We find that nerve fibres of many copepods seem to be designed for rapid signalling.
A D, Davis +3 more
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Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
, 2023 In neuroscience, it is of interest to consider all possible modes of information transfer between neurons in order to fully understand processing in the brain.
Christoph Simon (3741511) +2 more
core +1 more source
Advanced Science, EarlyView.An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu +11 more
wiley +1 more source