Post-synaptic density proteins in oligodendrocytes are required for activity-dependent myelin sheath growth. [PDF]
iScienceSummary: Neuronal activity regulates myelination in the central nervous system, highlighting the critical importance of axon-oligodendrocyte communications in myelin physiology and function.
Masson MA +3 more
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Myelinating Schwann Cell Polarity and Mechanically-Driven Myelin Sheath Elongation. [PDF]
Front Cell Neurosci, 2017 Myelin sheath geometry, encompassing myelin sheath thickness relative to internodal length, is critical to optimize nerve conduction velocity and these parameters are carefully adjusted by the myelinating cells in mammals.
Tricaud N.
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Microglia phagocytose myelin sheaths to modify developmental myelination [PDF]
Nature Neuroscience, 2020 During development, oligodendrocytes contact and wrap neuronal axons with myelin. Similarly to neurons and synapses, excess myelin sheaths are produced and selectively eliminated, but how elimination occurs is unknown. Microglia, the resident immune cells of the central nervous system, engulf surplus neurons and synapses. To determine whether microglia
Alexandria N. Hughes, Bruce Appel
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Neurokeratin Network of Myelin Sheaths [PDF]
Nature, 1960 THE recent communication of Tewari and Bourne1 on the neurokeratin network of peripheral nerve fibres is valuable not only for its intrinsic content but also because it validates the histological procedures, findings and arguments derived therefrom, by which it was concluded that neurokeratin formations are part of the architecture of the nerve fibres ...
M A, MACCONAILL, E, GURR
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Functional role of the overexpression of the myelin and lymphocyte protein MAL in Schwann cells [PDF]
, 2013 For fast propagation of action potentials in the nervous system, higher vertebrates have developed a specialized plasma membrane structure, the myelin, ensheathing nerve fibers. Myelin sheaths are formed by Schwann cells in the peripheral nervous system (
Schmid, Daniela
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Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo [PDF]
, 2012 <b>Background</b> Myelination is an exquisite and dynamic example of heterologous cell-cell interaction, which consists of the concentric wrapping of multiple layers of oligodendrocyte membrane around neuronal axons.
Strachan, D. +19 more
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Differential expression and MAL-dependent targeting of the L-MAG and S-MAG isoforms to myelin membranes [PDF]
, 2003 Many degenerative diseases of the nervous system, including Multiple Sclerosis and peripheral neuropathies, are triggered by an impaired interaction between the axons and their surrounding myelin sheaths.
Erb, Michael
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Particular aspects of myelin-axon interactions in health and disease : the expression of myelin-associated glycoprotein isoforms in CNS and PNS. Early axonal pathology in the dysmyelinating peripheral neuropathy CMT1A [PDF]
, 2007 An intact myelin sheath is crucial for the rapid propagation of action potentials along myelinated axons. There are many neurodegenerative diseases associated with defect myelin sheaths resulting in severe clinical symptoms such as multiple sclerosis ...
Flück, Bettina
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CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes [PDF]
, 2015 Since Río-Hortega's description of oligodendrocyte morphologies nearly a century ago, many studies have observed myelin sheath-length diversity between CNS regions [1, 2, 3]. Myelin sheath length directly impacts axonal conduction velocity by influencing
ffrench-Constant, Charles +2 more
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Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo. [PDF]
Nat Neurosci, 2018 How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+]i in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high frequency of [Ca2+]i transients and ...
Krasnow AM +4 more
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