Post-synaptic density proteins in oligodendrocytes are required for activity-dependent myelin sheath growth [PDF]
iScienceSummary: Neuronal activity regulates myelination in the central nervous system, highlighting the critical importance of axon-oligodendrocyte communications in myelin physiology and function.
Mary-Amélie Masson +3 more
doaj +3 more sources
A diffusion MRI model for random walks confined on cylindrical surfaces: towards non-invasive quantification of myelin sheath radius [PDF]
Frontiers in PhysicsIntroductionQuantifying the myelin sheath radius of myelinated axons in vivo is important for understanding, diagnosing, and monitoring various neurological disorders.
Erick Jorge Canales-Rodríguez +2 more
exaly +6 more sources
Diffusion effects in myelin sheath free induction decay
Journal of Magnetic Resonance, 2018 Myelin sheath microstructure and composition produce MR signal decay characteristics that can be used to evaluate status and outcome of demyelinating disease. We extend a recently proposed model of neuronal magnetic susceptibility, that accounts for both
Felix Kurz +2 more
exaly +3 more sources
Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, plasticity, and density of resident glial cells [PDF]
GliaMyelin basic protein (Mbp) is essential for both elaboration and maintenance of CNS myelin, and its reduced accumulation results in hypomyelination. How different Mbp mRNA levels affect myelin dimensions across the lifespan and how resident glial cells ...
Pierre Chaurand +2 more
exaly +7 more sources
A Nanoscale Model System for the Human Myelin Sheath [PDF]
Biomacromolecules, 2021 Here, we for the first time establish nanodiscs with the challenging lipid composition of myelin of the peripheral or central nervous systems, respectively (PNS and CNS, both containing >40% cholesterol, which so far has been thought to be detrimental for nanodisc formation).Thus, we prove that more complex lipid model membrane systems are in ...
Matthias Hoffmann +11 more
openaire +5 more sources
Clinical concentration of sevoflurane had no short-term effect on the myelin sheath in prefrontal cortex of aged marmosets [PDF]
Frontiers in NeuroscienceIntroductionThe fragile brain includes both the developing brain in childhood and the deteriorating brain in elderly. While the effects of general anesthesia on the myelin sheath of developing brain have been well-documented, limited research has ...
Zhengjie Miao +6 more
doaj +2 more sources
Oligodendrocytes express synaptic proteins that modulate myelin sheath formation. [PDF]
Nat Commun, 2019 Vesicular release from neurons promotes myelin sheath growth on axons. Oligodendrocytes express proteins that allow dendrites to respond to vesicular release at synapses, suggesting that axon-myelin contacts use similar communication mechanisms as ...
Hughes AN, Appel B.
europepmc +2 more sources
Entangled biphoton generation in the myelin sheath.
Physical Review EConsciousness within the brain hinges on the synchronized activities of millions of neurons, but the mechanism responsible for orchestrating such synchronization remains elusive. In this study we employ cavity quantum electrodynamics to explore entangled
Zefei Liu, Yong-Cong Chen, Ping Ao
semanticscholar +4 more sources
Dipolar induced spin-lattice relaxation in the myelin sheath: A molecular dynamics study. [PDF]
Sci Rep, 2019 Interactions between hydrogen protons of water molecules and macromolecules within the myelin sheath surrounding the axons are a major factor influencing the magnetic resonance (MR) contrast in white matter (WM) regions.
Schyboll F +3 more
europepmc +2 more sources
Zebrafish oligodendrocyte lineage cells use the postsynaptic protein Gephyrin to myelinate GABAergic axons and limit myelin sheath growth [PDF]
Nature CommunicationsAxon myelination can tune neuronal circuits through placement and modulation of different patterns of myelin sheaths on distinct types of axons. How myelin formation is coordinated on distinct axon classes remains largely unknown.
Natalie J. Carey +2 more
doaj +2 more sources