Results 61 to 70 of about 34,938 (236)

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Respiratory infection with influenza A virus delays remyelination and alters oligodendrocyte metabolism

iScience
Summary: Peripheral viral infection disrupts oligodendrocyte (OL) homeostasis such that endogenous remyelination may be affected. Here, we demonstrate that influenza A virus infection perpetuated a demyelination- and disease-associated OL phenotype ...
Allison Y. Louie, Jenny Drnevich, Jennifer L. Johnson, Meagan Woodard, Anna V. Kukekova, Rodney W. Johnson, Andrew J. Steelman   +6 more
doaj   +1 more source

Regenerative Capacity of Macrophages for Remyelination

Frontiers in Cell and Developmental Biology, 2016
White matter injury, consisting of loss of axons, myelin and oligodendrocytes, is common in many neurological disorders and is believed to underlie several motor and sensory deficits. Remyelination is the process in which the insulative myelin sheath is
Khalil eRawji, Manoj eMishra, V Wee eYong   +2 more
doaj   +1 more source

Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination

Journal of Neuroinflammation, 2023
Highlights AhR regulates remyelination following cuprizone-induced demyelination. Deletion of AhR in adult microglia restrains efficient remyelination.
Yumeng Wang, Jingxian Sun, Keying Zhu, Danjie Wang, Xiaoqiang Zhao, Hongyu Zhang, Shuai Wu, Yanqing Wang, Jun Wang   +8 more
doaj   +1 more source

Neural precursor cells derived from induced pluripotent stem cells exhibit reduced susceptibility to infection with a neurotropic coronavirus. [PDF]

, 2017
The present study examines the susceptibility of mouse induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) to infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV).
Lane, Thomas E, Mangale, Vrushali, Marro, Brett S, Plaisted, Warren C, Walsh, Craig M   +4 more
core   +1 more source

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

Remyelination in multiple sclerosis from the miRNA perspective

Frontiers in Molecular Neuroscience, 2023
Remyelination relies on the repair of damaged myelin sheaths, involving microglia cells, oligodendrocyte precursor cells (OPCs), and mature oligodendrocytes.
Karina Maciak, Angela Dziedzic, Joanna Saluk   +2 more
doaj   +1 more source

AxonDeepSeg: automatic axon and myelin segmentation from microscopy data using convolutional neural networks [PDF]

, 2017
Segmentation of axon and myelin from microscopy images of the nervous system provides useful quantitative information about the tissue microstructure, such as axon density and myelin thickness. This could be used for instance to document cell morphometry
Antonsanti, Pierre-Louis, Cohen-Adad, Julien, Herman, Victor, Perone, Christian Samuel, Wabartha, Maxime, Zaimi, Aldo   +5 more
core   +3 more sources

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function

Nature Communications
Myelin loss induces neural dysfunction and contributes to the pathophysiology of neurodegenerative diseases, injury conditions, and aging. Because remyelination is often incomplete, better understanding endogenous remyelination and developing ...
Gustavo Della-Flora Nunes, Lindsay A. Osso, Johana A. Haynes, Lauren Conant, Michael A. Thornton, Michael E. Stockton, Katherine A. Brassell, Amanda Morris, Yessenia I. Mancha Corchado, John A. Gaynes, Anthony R. Chavez, Michaelanne B. Woerner, Deidre A. MacKenna, Aryan Alavi, Anne Danks, Alon Poleg-Polsky, Rohan Gandhi, Jeffrey A. Vivian, Daniel J. Denman, Ethan G. Hughes   +19 more
doaj   +1 more source