Results 61 to 70 of about 26,726 (251)

Oligodendroglial primary cilium heterogeneity during development and demyelination/remyelination

Frontiers in Cellular Neuroscience, 2022
The primary cilium (PC) has emerged as an indispensable cellular antenna essential for signal transduction of important cell signaling pathways. The rapid acquisition of knowledge about PC biology has raised attention to PC as a therapeutic target in ...
Giada Delfino, Giada Delfino, Giada Delfino, Karelle Bénardais, Karelle Bénardais, Karelle Bénardais, Karelle Bénardais, Julien Graff, Julien Graff, Brigitte Samama, Brigitte Samama, Brigitte Samama, Brigitte Samama, Maria Cristina Antal, Maria Cristina Antal, Maria Cristina Antal, Maria Cristina Antal, M. Said Ghandour, M. Said Ghandour, Nelly Boehm, Nelly Boehm, Nelly Boehm, Nelly Boehm   +22 more
doaj   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination

Journal of Neuroinflammation, 2023
Highlights AhR regulates remyelination following cuprizone-induced demyelination. Deletion of AhR in adult microglia restrains efficient remyelination.
Yumeng Wang, Jingxian Sun, Keying Zhu, Danjie Wang, Xiaoqiang Zhao, Hongyu Zhang, Shuai Wu, Yanqing Wang, Jun Wang   +8 more
doaj   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration

npj Regenerative Medicine
Regulation of myeloid cell activity is critical for successful myelin regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis (MS).
Jingwen Hu, George S. Melchor, Dimitrios Ladakis, Joan Reger, Hee Won Kim, Kelly A. Chamberlain, Nataliia V. Shults, Helena C. Oft, Victoria N. Smith, Lauren M. Rosko, Erqiu Li, Maryna Baydyuk, Meng-Meng Fu, Pavan Bhargava, Jeffrey K. Huang   +14 more
doaj   +1 more source

Myelin Recovery in Multiple Sclerosis: The Challenge of Remyelination

Brain Sciences, 2013
Multiple sclerosis (MS) is the most common demyelinating and an autoimmune disease of the central nervous system characterized by immune-mediated myelin and axonal damage, and chronic axonal loss attributable to the absence of myelin sheaths.
Edward L. Hogan, Ewa Kurowska, Naren L. Banik, Maria Podbielska   +3 more
doaj   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Macrophages Regulate Schwann Cell Maturation after Nerve Injury

Cell Reports, 2018
Summary: Pro-regenerative macrophages are well known for their role in promoting tissue repair; however, their specific roles in promoting regeneration of the injured nerve are not well defined.
Jo Anne Stratton, Alexandra Holmes, Nicole L. Rosin, Sarthak Sinha, Mohit Vohra, Nicole E. Burma, Tuan Trang, Rajiv Midha, Jeff Biernaskie   +8 more
doaj   +1 more source

Remyelination of the injured spinal cord [PDF]

, 2007
Contusive spinal cord injury (SCI) can result in necrosis of the spinal cord, but often long white matter tracts outside of the central necrotic core are demyelinated. One experimental strategy to improve functional outcome following SCI is to transplant myelin-forming cells to remyelinate these axons and improve conduction.
Masanori, Sasaki, Bingcang, Li, Karen L, Lankford, Christine, Radtke, Jeffery D, Kocsis   +4 more
openaire   +2 more sources