Results 41 to 50 of about 26,726 (251)

Regenerative Effects of CDP-Choline: A Dose-Dependent Study in the Toxic Cuprizone Model of De- and Remyelination

Pharmaceuticals, 2021
Inflammatory attacks and demyelination in the central nervous system (CNS) are the key factors responsible for the damage of neurons in multiple sclerosis (MS).
Viktoria Gudi, Nora Schäfer, Stefan Gingele, Martin Stangel, Thomas Skripuletz   +4 more
doaj   +1 more source

Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17

, 2015
The identification of the molecular network that supports oligodendrocyte (OL) regeneration under demyelinating conditions has been a primary goal for regenerative medicine in demyelinating disorders.
Aguirre, Adan, Klingener, Michael, Crawford, Howard, Palazuelos Diego, Javier, Raines, Elaine   +4 more
core   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Influence of progesterone application on trigeminal nerve root-entry zone remyelination in experiment

Ukrainian Neurosurgical Journal, 2007
The results of trigeminal nerve root-entry zone remyelination experimental study are presented. Original experimental model of trigeminal nerve root focal toxic demyelination was used.
Yu. Yu. Chomolyak
doaj   +1 more source

Therapeutic effect of combination vitamin D3 and siponimod on remyelination and modulate microglia activation in cuprizone mouse model of multiple sclerosis

Frontiers in Behavioral Neuroscience, 2023
Stimulation of remyelination is critical for the treatment of multiple sclerosis (MS) to alleviate symptoms and protect the myelin sheath from further damage. The current study aimed to investigate the possible therapeutic effects of combining vitamin D3
Kholoud M. Al-Otaibi, Kholoud M. Al-Otaibi, Badrah S. Alghamdi, Badrah S. Alghamdi, Maryam A. Al-Ghamdi, Maryam A. Al-Ghamdi, Maryam A. Al-Ghamdi, Rasha A. Mansouri, Ghulam Md Ashraf, Ghulam Md Ashraf, Ulfat M. Omar, Ulfat M. Omar   +11 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

In vivo imaging reveals mature Oligodendrocyte division in adult Zebrafish

Cell Regeneration, 2021
Whether mature oligodendrocytes (mOLs) participate in remyelination has been disputed for several decades. Recently, some studies have shown that mOLs participate in remyelination by producing new sheaths.
Suqi Zou, Bing Hu
doaj   +1 more source

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

Age-impaired remyelination is associated with dysregulated microglial transitions

Nature Communications
Multiple sclerosis (MS) is a chronic, inflammatory condition characterized by neurodegeneration and lost myelin, or demyelination. This lost myelin may be regenerated in people with MS through a process called remyelination, that is prone to failure and ...
Sameera Zia, Marianela E. Traetta, Charbel S. Baaklini, Brady P. Hammond, Rebecca K. John, Katherine M. Souter, Niels Meijns, Larry K. A. Afun, Sharmistha Panda, Fernando González Ibáñez, Mena K. Burr, Eva Dhupia, Abhisha M. Rathod, Andre O. Faria, Dhruvish Zaveri, Sowmya Challa, Eugene Hahn, Sohrab B. Manesh, Kelly V. Lee, Madelene F. S. Ho, Timothy N. Friedman, Aislinn D. Maguire, Arina Pang, Olivia Farkas, Bożena Szulc, Luiz Tenorio, Diya Vyas, Olivia R. La Caprara, Wolfram Tetzlaff, Sarthak Sinha, Gregory J. Duncan, Anastassia Voronova, Bradley J. Kerr, Marie-Eve Tremblay, Jeff Biernaskie, Geert Schenk, Jason R. Plemel   +36 more
doaj   +1 more source

Positive effect of evobrutinib in CNS remyelination models and lack of synergy with clemastine—A dose response study

Multiple Sclerosis Journal - Experimental, Translational and Clinical
Background To recover normal functions, remyelination in multiple sclerosis is crucial. Although endogenous remyelination occurs, it is often insufficient, and finding molecules promoting repair of demyelinated lesions is needed.
E. Martin, M.S. Aigrot, N. Frère, R. Lepaulmier, B. Stankoff, U. Boschert, C. Lubetzki, B. Zalc   +7 more
doaj   +1 more source