Results 21 to 30 of about 19,756 (195)

Experimental models of demyelination and remyelination

Neurología (English Edition), 2020
Experimental animal models constitute a useful tool to deepen our knowledge of central nervous system disorders. In the case of multiple sclerosis, however, there is no such specific model able to provide an overview of the disease; multiple models covering the different pathophysiological features of the disease are therefore necessary.We reviewed the
L. Torre-Fuentes, L. Moreno-Jiménez, V. Pytel, J.A. Matías-Guiu, U. Gómez-Pinedo, J. Matías-Guiu   +5 more
openaire   +3 more sources

rHIgM22 enhances remyelination in the brain of the cuprizone mouse model of demyelination

Neurobiology of Disease, 2017
Failure of oligodendrocyte precursor cells (OPCs) to differentiate and remyelinate axons is thought to be a major cause of the limited ability of the central nervous system to repair plaques of immune-mediated demyelination in multiple sclerosis (MS ...
Ariana P. Mullin, Charlene Cui, Yu Wang, Jing Wang, Erika Troy, Anthony O. Caggiano, Tom J. Parry, Raymond W. Colburn, Elias Pavlopoulos   +8 more
doaj   +1 more source

In vivo imaging reveals mature Oligodendrocyte division in adult Zebrafish

Cell Regeneration, 2021
Whether mature oligodendrocytes (mOLs) participate in remyelination has been disputed for several decades. Recently, some studies have shown that mOLs participate in remyelination by producing new sheaths.
Suqi Zou, Bing Hu
doaj   +1 more source

Therapeutic effect of combination vitamin D3 and siponimod on remyelination and modulate microglia activation in cuprizone mouse model of multiple sclerosis

Frontiers in Behavioral Neuroscience, 2023
Stimulation of remyelination is critical for the treatment of multiple sclerosis (MS) to alleviate symptoms and protect the myelin sheath from further damage. The current study aimed to investigate the possible therapeutic effects of combining vitamin D3
Kholoud M. Al-Otaibi, Kholoud M. Al-Otaibi, Badrah S. Alghamdi, Badrah S. Alghamdi, Maryam A. Al-Ghamdi, Maryam A. Al-Ghamdi, Maryam A. Al-Ghamdi, Rasha A. Mansouri, Ghulam Md Ashraf, Ghulam Md Ashraf, Ulfat M. Omar, Ulfat M. Omar   +11 more
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Influence of progesterone application on trigeminal nerve root-entry zone remyelination in experiment

Ukrainian Neurosurgical Journal, 2007
The results of trigeminal nerve root-entry zone remyelination experimental study are presented. Original experimental model of trigeminal nerve root focal toxic demyelination was used.
Yu. Yu. Chomolyak
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

Age-impaired remyelination is associated with dysregulated microglial transitions

Nature Communications
Multiple sclerosis (MS) is a chronic, inflammatory condition characterized by neurodegeneration and lost myelin, or demyelination. This lost myelin may be regenerated in people with MS through a process called remyelination, that is prone to failure and ...
Sameera Zia, Marianela E. Traetta, Charbel S. Baaklini, Brady P. Hammond, Rebecca K. John, Katherine M. Souter, Niels Meijns, Larry K. A. Afun, Sharmistha Panda, Fernando González Ibáñez, Mena K. Burr, Eva Dhupia, Abhisha M. Rathod, Andre O. Faria, Dhruvish Zaveri, Sowmya Challa, Eugene Hahn, Sohrab B. Manesh, Kelly V. Lee, Madelene F. S. Ho, Timothy N. Friedman, Aislinn D. Maguire, Arina Pang, Olivia Farkas, Bożena Szulc, Luiz Tenorio, Diya Vyas, Olivia R. La Caprara, Wolfram Tetzlaff, Sarthak Sinha, Gregory J. Duncan, Anastassia Voronova, Bradley J. Kerr, Marie-Eve Tremblay, Jeff Biernaskie, Geert Schenk, Jason R. Plemel   +36 more
doaj   +1 more source

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source