Results 21 to 30 of about 22,271 (244)
Microglia-derived APOE2 improves remyelination even in the presence of endogenous APOE4 [PDF]
J NeuroinflammationGeorgia L. Nolt +13 more
openalex +2 more sources
Life Science Alliance, 2022 PRMT1 regulates MHC-associated microglia cluster during de/remyelination. Remyelination failure in multiple sclerosis leads to progressive demyelination and inflammation, resulting in neurodegeneration and clinical decline.
Jeesan Lee +6 more
doaj +1 more source
Remyelination in animal models of multiple sclerosis: finding the elusive grail of regeneration
Frontiers in Molecular Neuroscience, 2023 Remyelination biology and the therapeutic potential of restoring myelin sheaths to prevent neurodegeneration and disability in multiple sclerosis (MS) has made considerable gains over the past decade with many regeneration strategies undergoing tested in
Davin Packer +2 more
doaj +1 more source
Microglia promote remyelination independent of their role in clearing myelin debris
Cell Reports, 2023 Summary: Multiple sclerosis (MS) is an inflammatory disease characterized by myelin loss. While therapies exist to slow MS progression, no treatment currently exists for remyelination.
Charbel S. Baaklini +17 more
doaj +1 more source
Neurology Neuroimmunology & Neuroinflammation, 2021 Neuroaxonal loss is believed to underpin the progressive disability that characterizes multiple sclerosis (MS). While focal inflammatory demyelination is a principal cause of acute axonal transection and subsequent axonal degeneration, the gradual attrition of permanently demyelinated axons may also contribute to tissue damage, particularly in the ...
Klistorner, Alexandr, Barnett, Michael
openaire +2 more sources
In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis
eLife, 2023 Remyelination is crucial to recover from inflammatory demyelination in multiple sclerosis (MS). Investigating remyelination in vivo using magnetic resonance imaging (MRI) is difficult in MS, where collecting serial short-interval scans is challenging ...
Maxime Donadieu +14 more
doaj +1 more source
Animal models to investigate the effects of inflammation on remyelination in multiple sclerosis
Frontiers in Molecular Neuroscience, 2022 Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). In people with MS, impaired remyelination and axonal loss lead to debilitating long-term neurologic deficits.
Marjan Gharagozloo +3 more
doaj +1 more source
eLife, 2016 Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss.
Feng Mei +16 more
doaj +1 more source
Delayed Demyelination and Impaired Remyelination in Aged Mice in the Cuprizone Model
Cells, 2020 To unravel the failure of remyelination in multiple sclerosis (MS) and to test promising remyelinating treatments, suitable animal models like the well-established cuprizone model are required. However, this model is only standardized in young mice. This
Stefan Gingele +7 more
doaj +1 more source
A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.
PLoS ONE, 2021 Incomplete remyelination is frequent in multiple sclerosis (MS)-lesions, but there is no established marker for recent remyelination. We investigated the role of the oligodendrocyte/myelin protein ermin in de- and remyelination in the cuprizone (CPZ ...
Intakhar Ahmad +3 more
doaj +1 more source