Results 21 to 30 of about 26,726 (251)

Transcriptional analysis of astrocytes reveals protective functions during remyelination [PDF]

, 2020
In Multiple Sclerosis (MS), the insulating membrane that ensheaths axons termed myelin, is lost by a process known as demyelination. Initial regeneration of myelin, termed remyelination, restores neuronal function.
Molina-González, Irene
core   +1 more source

Fingolimod modulates microglial activation to augment markers of remyelination [PDF]

, 2011
Introduction Microglial activation in multiple sclerosis has been postulated to contribute to long-term neurodegeneration during disease. Fingolimod has been shown to impact on the relapsing remitting phase of disease by modulating autoreactive T-cell ...
Giovannoni Gavin, Jackson Samuel J, Jackson, SJ, Baker, D, Gavin Giovannoni, Baker David, Giovannoni, G, David Baker, Samuel J Jackson   +8 more
core   +1 more source

Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis [PDF]

, 2012
Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide.
Aigner, Ludwig, Ludwig Aigner, Francisco J Rivera, Rivera, Francisco J   +3 more
core   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury. [PDF]

Adv Sci (Weinh)
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Pan T, Huang Y, Zhang J, Tian S, Li Z, Li X, Zhang Y, Wang D, Ye S, Jin M, Ling N, Yan W, Nan K, Wu W.   +13 more
europepmc   +2 more sources

A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.

PLoS ONE, 2021
Incomplete remyelination is frequent in multiple sclerosis (MS)-lesions, but there is no established marker for recent remyelination. We investigated the role of the oligodendrocyte/myelin protein ermin in de- and remyelination in the cuprizone (CPZ ...
Intakhar Ahmad, Stig Wergeland, Eystein Oveland, Lars Bø   +3 more
doaj   +1 more source

Remyelination Therapy in Multiple Sclerosis

Frontiers in Neurology, 2015
Multiple Sclerosis (MS) is an immune-mediated disorder of the central nervous system that results in destruction of the myelin sheath that surrounds axons and eventual neurodegeneration.
Danielle E. Harlow, Justin eHonce, Augusto A. Miravalle   +2 more
doaj   +1 more source

Conduction in segmentally demyelinated mammalian central axons. [PDF]

, 1997
The prominent symptoms associated with central demyelinating diseases such as multiple sclerosis (MS) are primarily caused by conduction deficits in affected axons.
Paul A. Felts, Baker, Theresa A., Theresa A. Baker, Felts, PA, Smith, KJ, Smith, Kenneth J., Felts, Paul A.; id_orcid, Kenneth J. Smith, Baker, TA   +8 more
core   +1 more source

Region Specific miRNA-mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Sapra A, Rai NK, Niepokny TD, Courtney H, Tripathi A, Dutta R.   +5 more
europepmc   +2 more sources

A New Model of Cuprizone-Mediated Demyelination/Remyelination

ASN Neuro, 2014
In the central nervous system, demyelinating diseases, such as multiple sclerosis, result in devastating long-term neurologic damage, in part because of the lack of effective remyelination in the adult human brain.
Hilary H. Sachs, Kathryn K. Bercury, Daniela C. Popescu, S. Priya Narayanan, Wendy B. Macklin   +4 more
doaj   +1 more source

Brain region dependent molecular signatures and myelin repair following chronic demyelination

Frontiers in Cellular Neuroscience, 2023
Multiple sclerosis (MS) is the most prevalent demyelinating disease of the central nervous system, characterized by myelin destruction, axonal degeneration, and progressive loss of neurological functions.
Grace Samtani, Grace Samtani, Sunja Kim, Danielle Michaud, Andrew E. Hillhouse, Joseph A. Szule, Kranti Konganti, Jianrong Li, Jianrong Li   +8 more
doaj   +1 more source