Results 21 to 30 of about 25,880 (231)

CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities [PDF]

, 2022
Remyelination, the myelin regenerative response that follows demyelination, restores saltatory conduction and function and sustains axon health. Its declining efficiency with disease progression in the chronic autoimmune disease multiple sclerosis (MS ...
Simons, Mikael, Franklin, Robin J. M.
core   +1 more source

Remyelination Trials [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2021
Neuroaxonal loss is believed to underpin the progressive disability that characterizes multiple sclerosis (MS). While focal inflammatory demyelination is a principal cause of acute axonal transection and subsequent axonal degeneration, the gradual attrition of permanently demyelinated axons may also contribute to tissue damage, particularly in the ...
Klistorner, Alexandr, Barnett, Michael
openaire   +2 more sources

TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination [PDF]

, 2021
Upon demyelinating injury, microglia orchestrate a regenerative response that promotes myelin repair, thereby restoring rapid signal propagation and protecting axons from further damage.
Bosch-Queralt, Mar, Klose, Christian, Christian Klose, Cantuti-Castelvetri, Ludovico, Ozgun Gokce, Lu Liu, Martina Schifferer, Gokce, Ozgun, Simons, Mikael, Garyfallia Gouna, Mar Bosch-Queralt, Mikael Simons, Schifferer, Martina, Gouna, Garyfallia, Ludovico Cantuti-Castelvetri, Liu, Lu   +15 more
core   +1 more source

The Neurovascular Niche: A Gathering Venue for Neuroinflammation and Remyelination in Multiple Sclerosis. [PDF]

Acta Physiol (Oxf)
ABSTRACT In the central nervous system (CNS), the tissue microenvironment is continuously monitored and regulated to secure the unobstructed function of neurons and of their networks. This is a key function of the neurovascular niche (NVN), which is the interface between the cells of the nervous tissue and the cells and the content of blood vessels. It
Kazanis I, Silva ME, de la Fuente AG, de Castro F, Rivera FJ.   +4 more
europepmc   +2 more sources

Transcriptional analysis of astrocytes reveals protective functions during remyelination [PDF]

, 2020
In Multiple Sclerosis (MS), the insulating membrane that ensheaths axons termed myelin, is lost by a process known as demyelination. Initial regeneration of myelin, termed remyelination, restores neuronal function.
Molina-González, Irene
core   +1 more source

T₁ Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Wright SJ, McKay SG, Bou JR, Bao F, Truong VB, Li C, Jiang L, Memon AB, Haacke EM, Ge Y, Chen Y.   +10 more
europepmc   +2 more sources

Fingolimod modulates microglial activation to augment markers of remyelination [PDF]

, 2011
Introduction Microglial activation in multiple sclerosis has been postulated to contribute to long-term neurodegeneration during disease. Fingolimod has been shown to impact on the relapsing remitting phase of disease by modulating autoreactive T-cell ...
Giovannoni Gavin, Jackson Samuel J, Jackson, SJ, Baker, D, Gavin Giovannoni, Baker David, Giovannoni, G, David Baker, Samuel J Jackson   +8 more
core   +1 more source

Effects of calcitriol and fingolimod on remyelination in the cuprizone model [PDF]

, 2020
Multiple sclerosis (MS) is a chronic disease characterized by inflammation, demyelination, and neurodegeneration of the central nervous system (CNS). There is no cure. Current treatments target the autoimmune aspects of MS but do not directly improve CNS
Nystad, Agnes Elisabeth
core   +1 more source

Molecular Mediators Associated With Myelination, Demyelination, and Remyelination in the Peripheral Nervous System. [PDF]

J Peripher Nerv Syst
ABSTRACT The peripheral nervous system (PNS) is responsible for innervating all regions of the body outside of the central nervous system (CNS), the latter consisting of the brain, spinal cord, and optic nerves. While myelin is an essential component for the efficient functioning of both CNS and peripheral nerve cells, it is particularly important for ...
Hagen KM, Ousman SS.
europepmc   +2 more sources

Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis [PDF]

, 2012
Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide.
Aigner, Ludwig, Ludwig Aigner, Francisco J Rivera, Rivera, Francisco J   +3 more
core   +1 more source