Results 11 to 20 of about 69,674 (261)
Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells. [PDF]
PLoS ONE, 2017 Oligodendrocytes myelinate axons and form myelin sheaths in the central nervous system. The development of therapies for demyelinating diseases, including multiple sclerosis and leukodystrophies, is a challenge because the pathogenic mechanisms of ...
Tomoko Yamashita +12 more
doaj +1 more source
The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina
Cell Reports, 2023 Summary: Oligodendrocytes are specialized cells that insulate and support axons with their myelin membrane, allowing proper brain function. Here, we identify lamin A/C (LMNA/C) as essential for transcriptional and functional stability of myelinating ...
Mathilde Pruvost +17 more
doaj +1 more source
Cyclooxygenase-2 expression in oligodendrocytes increases sensitivity to excitotoxic death
Journal of Neuroinflammation, 2010 Background We previously found that cyclooxygenase 2 (COX-2) was expressed in dying oligodendrocytes at the onset of demyelination in the Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) model of multiple sclerosis (MS ...
Rojas Monica A +6 more
doaj +1 more source
Gliopathy of Demyelinating And Non-Demyelinating Strains Of Mouse Hepatitis Virus.
Frontiers in Cellular Neuroscience, 2015 Demyelination in the central nervous system induced by neurovirulent strains of Mouse Hepatitis Virus (MHV) is mediated by the viral spike glycoprotein, but it is not clear whether the mechanism of this disease pathology involves direct viral infection ...
Lawrence Charles Kenyon +7 more
doaj +1 more source
Oligodendrocyte-specific ATF4 inactivation does not influence the development of EAE
Journal of Neuroinflammation, 2019 Background Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory demyelinating and neurodegenerative diseases of the CNS.
Yuan Yue +4 more
doaj +1 more source
Demyelination and oligodendrocytes
Rinsho Shinkeigaku, 2011 Although neurological sequelae are attributable to poor regeneration of the central nervous system, oligodendrocytes demonstrate robust regenerative response even in adults. Accumulating evidence indicates that the glial cells identified by surface expression of the proteoglycan NG2 are the cellular source of newly-developed oligodendrocytes following ...
Itoh, Takayuki +4 more
openaire +3 more sources
PLoS ONE, 2017 Within the microenvironment of multiple sclerosis lesions, oligodendrocytes are subject to metabolic stress reflecting effects of focal ischemia and inflammation.
Vijayaraghava T S Rao +9 more
doaj +1 more source
Disease-Associated Oligodendrocyte: New Player in Alzheimer's Disease and CNS Pathologies
Journal of Integrative Neuroscience, 2023 Considerable evidence has shown that the breakdown of myelin has been linked to Alzheimer’s disease (AD). Considering the vulnerability of oligodendrocytes to Alzheimer’s disease, the myelin sheath breakdown and degeneration are easily induced ...
Peng Chen, ZhiLei Guo, Benhong Zhou
doaj +1 more source
TASK-1 channels in oligodendrocytes: A role in ischemia mediated disruption
Neurobiology of Disease, 2013 Oligodendrocytes are the myelinating cells of the CNS and, like neurons, are highly sensitive to ischemic damage. However, the mechanisms underlying cytotoxicity in oligodendrocytes during hypoxic/ischemic episodes are not fully understood. TASK-1 is a K+
Virginia Hawkins, Arthur Butt
doaj +1 more source
Fluids and Barriers of the CNS, 2023 Background Oligodendrocyte lineage cells interact with the vasculature in the gray matter. Physical and functional interactions between blood vessels and oligodendrocyte precursor cells play an essential role in both the developing and adult brain ...
Justine S. C. Palhol +5 more
doaj +1 more source