A Single Dose of Atorvastatin Applied Acutely after Spinal Cord Injury Suppresses Inflammation, Apoptosis, and Promotes Axon Outgrowth, Which Might Be Essential for Favorable Functional Outcome. [PDF]
, 2018 The aim of our study was to limit the inflammatory response after a spinal cord injury (SCI) using Atorvastatin (ATR), a potent inhibitor of cholesterol biosynthesis.
Bacova, Maria +11 more
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Cyclooxygenase-2 expression in oligodendrocytes increases sensitivity to excitotoxic death
Journal of Neuroinflammation, 2010 Background We previously found that cyclooxygenase 2 (COX-2) was expressed in dying oligodendrocytes at the onset of demyelination in the Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) model of multiple sclerosis (MS ...
Rojas Monica A +6 more
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Gliopathy of Demyelinating And Non-Demyelinating Strains Of Mouse Hepatitis Virus.
Frontiers in Cellular Neuroscience, 2015 Demyelination in the central nervous system induced by neurovirulent strains of Mouse Hepatitis Virus (MHV) is mediated by the viral spike glycoprotein, but it is not clear whether the mechanism of this disease pathology involves direct viral infection ...
Lawrence Charles Kenyon +7 more
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Oligodendrocyte-specific ATF4 inactivation does not influence the development of EAE
Journal of Neuroinflammation, 2019 Background Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory demyelinating and neurodegenerative diseases of the CNS.
Yuan Yue +4 more
doaj +1 more source
Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. [PDF]
, 2013 NG2 (nerve/glial antigen2)-expressing cells represent the largest population of postnatal progenitors in the central nervous system and have been classified as oligodendroglial progenitor cells, but the fate and function of these cells remain ...
Chung, S-H +4 more
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PLoS ONE, 2017 Within the microenvironment of multiple sclerosis lesions, oligodendrocytes are subject to metabolic stress reflecting effects of focal ischemia and inflammation.
Vijayaraghava T S Rao +9 more
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Disease-Associated Oligodendrocyte: New Player in Alzheimer's Disease and CNS Pathologies
Journal of Integrative Neuroscience, 2023 Considerable evidence has shown that the breakdown of myelin has been linked to Alzheimer’s disease (AD). Considering the vulnerability of oligodendrocytes to Alzheimer’s disease, the myelin sheath breakdown and degeneration are easily induced ...
Peng Chen, ZhiLei Guo, Benhong Zhou
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The immunomodulatory oligodendrocyte [PDF]
Brain Research, 2016 Oligodendrocytes, the myelinating glial cells of the central nervous system (CNS), are due to their high specialization and metabolic needs highly vulnerable to various insults. This led to a general view that oligodendrocytes are defenseless victims during brain damage such as occurs in acute and chronic CNS inflammation.
Zeis, Thomas +2 more
openaire +3 more sources
Mesenchymal Stem Cells Promote Oligodendroglial Differentiation in Hippocampal Slice Cultures [PDF]
, 2009 We have previously shown that soluble factors derived from mesenchymal stem cells (MSCs) induce oligodendrogenic fate and differentiation in adult rat neural progenitors (NPCs) in vitro.
Aigner, Ludwig +12 more
core +1 more source
TASK-1 channels in oligodendrocytes: A role in ischemia mediated disruption
Neurobiology of Disease, 2013 Oligodendrocytes are the myelinating cells of the CNS and, like neurons, are highly sensitive to ischemic damage. However, the mechanisms underlying cytotoxicity in oligodendrocytes during hypoxic/ischemic episodes are not fully understood. TASK-1 is a K+
Virginia Hawkins, Arthur Butt
doaj +1 more source