Results 41 to 50 of about 88,496 (298)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Ramifications of microglial activation on oligodendrocytes in in vitro models of multiple sclerosis [PDF]

, 2010
Oligodendrocytes are the principal target of immune attack in multiple sclerosis (MS), where the immune system attacks the myelin sheath, leading to oligodendrocyte demise, compromised axonal saltatory conduction and eventually neuronal degeneration ...
Sevastou, I.
core  

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Mechanosensitivity of Human Oligodendrocytes [PDF]

Frontiers in Cellular Neuroscience, 2020
Oligodendrocytes produce and repair myelin, which is critical for the integrity and function of the central nervous system (CNS). Oligodendrocyte and oligodendrocyte progenitor cell (OPC) biology is modulated in vitro by mechanical cues within the magnitudes observed in vivo.
Daniela Espinosa-Hoyos, Suzanne R. Burstein, Jaaram Cha, Tanya Jain, Madhura Nijsure, Anna Jagielska, Anna Jagielska, Valentina Fossati, Krystyn J. Van Vliet, Krystyn J. Van Vliet, Krystyn J. Van Vliet   +10 more
openaire   +3 more sources

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Retrovirus-Mediated Gene Transfer and Galactocerebrosidase Uptake into Twitcher Glial Cells Results in Appropriate Localization and Phenotype Correction

Neurobiology of Disease, 2001
Galactocerebrosidase (GALC) is deficient in all tissues from human patients and animal models with globoid cell leukodystrophy (GLD) or Krabbe disease.
A. Luddi, M. Volterrani, M. Strazza, A. Smorlesi, M.A. Rafi, J. Datto, D.A. Wenger, E. Costantino-Ceccarini   +7 more
doaj   +1 more source

Efficient derivation of oligodendrocytes from marmoset ESCs.

, 2012
(A) Protocol for derivation of NS/PCs from marmoset ESCs, which efficiently generate oligodendrocytes. EBs were cultured in the presence of 1×10−6 M RA and 2 µM purmorphamine for 2 weeks.
Toshihiro Nomura (121816), Ikuo Tomioka (121813), Hiroko Shimada (121794), Hayao Ebise (121806), Takuji Maeda (121819), Michisuke Yuzaki (121827), Masaya Nakamura (121832), Yohei Okada (121798), Erika Sasaki (121830), Kazuhisa Kohda (121822), Hideyuki Okano (47690), Shin-ichi Ota (121809), Keiji Ibata (121802)   +12 more
core   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

pH Microdomains in Oligodendrocytes [PDF]

Journal of Biological Chemistry, 2004
Oligodendrocytes (OLs) are cells that produce myelin in the central nervous system. Here we use ratiometric pH indicator dye to analyze intracellular pH in OLs in culture. The results reveal alkaline microdomains, which predominate in the perikaryon and proximal dendrites, and acidic microdomains, which predominate in distal dendrites.
Hyun-ah, Ro, John H, Carson
openaire   +2 more sources

GAT-1 mediated GABA uptake in rat oligodendrocytes [PDF]

, 2017
Stimulated by the results of a recent paper on the effects of tiagabine, a selective inhibitor of the main GABA transporter GAT-1, on oligodendrogenesis, we verified the possibility that GAT-1 may be expressed in oligodendrocytes using immunocytochemical
Giorgia Fattorini, María Victoria Sánchez‐Gómez, FATTORINI, GIORGIA, MELONE, Marcello, CONTI, FIORENZO, Rogelio O. Arellano, Silvia Bassi, Carlos Matute, Matute, Carlos, BASSI, SILVIA, Marcello Melone, Arellano, Rogelio O, Sánchez Gómez, María Victoria, Fiorenzo Conti   +13 more
core   +1 more source