Results 31 to 40 of about 81,187 (302)

Fatty Acid Binding Protein 5 Mediates Cell Death by Psychosine Exposure through Mitochondrial Macropores Formation in Oligodendrocytes

Biomedicines, 2020
Oligodendrocytes, the myelinating cells in the central nervous system (CNS), are critical for producing myelin throughout the CNS. The loss of oligodendrocytes is associated with multiple neurodegenerative disorders mediated by psychosine.
An Cheng, Ichiro Kawahata, Kohji Fukunaga   +2 more
doaj   +1 more source

Cx32 and Cx47 mediate oligodendrocyte:astrocyte and oligodendrocyte:oligodendrocyte gap junction coupling

Neurobiology of Disease, 2011
In addition to the extensive gap junction coupling between astrocytes themselves, oligodendrocytes are thought to be exclusively coupled to astrocytes (O:A coupling) via heterotypic gap junctions composed of Cx47:Cx43 and Cx32:Cx30.
Sameh K. Wasseff, Steven S. Scherer
doaj   +1 more source

Histone deacetylase inhibitor upregulates peroxisomal fatty acid oxidation and inhibits apoptotic cell death in abcd1-deficient glial cells. [PDF]

PLoS ONE, 2013
In X-ALD, mutation/deletion of ALD gene (ABCD1) and the resultant very long chain fatty acid (VLCFA) derangement has dramatically opposing effects in astrocytes and oligodendrocytes.
Jaspreet Singh, Mushfiquddin Khan, Aurora Pujol, Mauhamad Baarine, Inderjit Singh   +4 more
doaj   +1 more source

Dystrophy of Oligodendrocytes and Adjacent Microglia in Prefrontal Gray Matter in Schizophrenia

Frontiers in Psychiatry, 2020
BackgroundSome evidence support the notion that microglia activation in acute state of schizophrenia might contribute to damage of oligodendrocytes and myelinated fibers.
Natalya A. Uranova, Olga V. Vikhreva, Valentina I. Rakhmanova, Diana D. Orlovskaya   +3 more
doaj   +1 more source

Mechanosensitivity of Human Oligodendrocytes [PDF]

Frontiers in Cellular Neuroscience, 2020
Oligodendrocytes produce and repair myelin, which is critical for the integrity and function of the central nervous system (CNS). Oligodendrocyte and oligodendrocyte progenitor cell (OPC) biology is modulated in vitro by mechanical cues within the magnitudes observed in vivo.
Daniela Espinosa-Hoyos, Suzanne R. Burstein, Jaaram Cha, Tanya Jain, Madhura Nijsure, Anna Jagielska, Anna Jagielska, Valentina Fossati, Krystyn J. Van Vliet, Krystyn J. Van Vliet, Krystyn J. Van Vliet   +10 more
openaire   +3 more sources

Epsilon Toxin from Clostridium perfringens Causes Inhibition of Potassium inward Rectifier (Kir) Channels in Oligodendrocytes

Toxins, 2020
Epsilon toxin (ETX), produced by Clostridium perfringens types B and D, causes serious neurological disorders in animals. ETX can bind to the white matter of the brain and the oligodendrocytes, which are the cells forming the myelin sheath around neuron ...
Jean Louis Bossu, Laetitia Wioland, Frédéric Doussau, Philippe Isope, Michel R. Popoff, Bernard Poulain   +5 more
doaj   +1 more source

Evidence for Cooperative Selection of Axons for Myelination by Adjacent Oligodendrocytes in the Optic Nerve. [PDF]

PLoS ONE, 2016
The cellular mechanisms that regulate the topographic arrangement of myelin internodes along axons remain largely uncharacterized. Recent clonal analysis of oligodendrocyte morphologies in the mouse optic nerve revealed that adjacent oligodendrocytes ...
Darragh M Walsh, Tobias D Merson, Kerry A Landman, Barry D Hughes   +3 more
doaj   +1 more source

The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes

, 2009
Elevations of the levels of N-acetyl-aspartyl-glutamate (NAAG) and N-acetyl-aspartate (NAA) are associated with myelin loss in the leucodystrophies Canavan's disease and Pelizaeus-Merzbacher-like disease. NAAG and NAA can activate and antagonize neuronal
Attwell, D., Koodziejczyk, Karolina, Kolodziejczyk, K., Wade, A., Kradttir, Ragnhildur, Wade, Anna, Karadottir, R., Hamilton, Nicola B.; id_orcid, Attwell, David, Hamilton, N. B.   +9 more
core   +1 more source

NF-κB activation protects oligodendrocytes against inflammation [PDF]

, 2017
NF-κB is a key player in inflammatory diseases, including multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). However, the effects of NF-κB activation on oligodendrocytes in MS and EAE remain unknown.
Stone, S., Ruth Schmidt-Ullrich, Schmidt-Ullrich, R., Lin, W., Sarrabeth Stone, Yue, Y., Yuan Yue, Durose, W., Wilaiwan Durose, Jamison, S., Stephanie Jamison, Wensheng Lin   +11 more
core   +1 more source

How Do Cells of the Oligodendrocyte Lineage Affect Neuronal Circuits to Influence Motor Function, Memory and Mood?

Frontiers in Cellular Neuroscience, 2018
Oligodendrocyte progenitor cells (OPCs) are immature cells in the central nervous system (CNS) that can rapidly respond to changes within their environment by modulating their proliferation, motility and differentiation.
Renee E. Pepper, Kimberley A. Pitman, Carlie L. Cullen, Kaylene M. Young   +3 more
doaj   +1 more source