Results 41 to 50 of about 21,830 (258)
Density-dependence of functional development in spiking cortical networks grown in vitro
, 2008 During development, the mammalian brain differentiates into specialized regions with distinct functional abilities. While many factors contribute to functional specialization, we explore the effect of neuronal density on the development of neuronal ...
A Tang +31 more
core +1 more source
Alignment of multiple glial cell populations in 3D nanofiber scaffolds: toward the development of multicellular implantable scaffolds for repair of neural injury [PDF]
, 2014 Non-neuronal cells of the central nervous system (CNS), termed "neuroglia," play critical roles in neural regeneration; therefore, replacement of glial populations via implantable nanofabricated devices (providing a growth-permissive niche) is a ...
Chari, Divya M. +4 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Neuronal Glial Crosstalk: Specific and Shared Mechanisms in Alzheimer’s Disease
Brain Sciences, 2022 The human brain maintains billions of neurons functional across the lifespan of the individual. The glial, supportive cells of the brain are indispensable to neuron elasticity.
Vishal Chavda +4 more
doaj +1 more source
, 2012 The simulation data presented here, and the conceptual framework developed for their interpretation are, both, in need of substantial refinement and extension.
Werner, prof. Gerhard
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
RNA content in motor and sensory neurons and surrounding neuroglia of mouse spinal cord under conditions of hypodynamia and following normalization [PDF]
The differences in the dynamics of reparative processes in RNA metabolism within the neuron-neuroglia unit after the cessation of hyper- and hypodynamia is dicussed.
Brumberg, V. A., Pevzner, L. A.
core +4 more sources
Release of VAMP5‐positive extracellular vesicles by retinal Müller glia in vivo
Journal of Extracellular Vesicles, 2022 Cell‐cell interactions in the central nervous system are based on the release of molecules mediating signal exchange and providing structural and trophic support through vesicular exocytosis and the formation of extracellular vesicles.
Valerie Demais +11 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2023 The neuroimmunology of traumatic brain injury (TBI) has recently gained recognition as a crucial element in the secondary pathophysiological consequences that occur following neurotrauma. Both immune cells residing within the central nervous system (CNS)
Hadi Abou-El-Hassan +7 more
doaj +1 more source