Results 31 to 40 of about 7,972 (202)

Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread

Neurobiology of Disease, 2014
Dementia with Lewy bodies (DLB), Parkinson’s disease (PD) and multiple system atrophy are characterized by the deposition of disease-associated α-synuclein.
Gabor G. Kovacs, Leonid Breydo, Ryan Green, Viktor Kis, Gina Puska, Péter Lőrincz, Laura Perju-Dumbrava, Regina Giera, Walter Pirker, Mirjam Lutz, Ingolf Lachmann, Herbert Budka, Vladimir N. Uversky, Kinga Molnár, Lajos László   +14 more
doaj   +1 more source

Anatomical and histological characterization of the filum terminale in dogs

Frontiers in Veterinary Science
The filum terminale (FT) remains poorly characterized in the veterinary literature, limiting understanding of its role in spinal cord and nerve root pathologies such as tethered cord syndrome.
Christoforos Posporis, Javier Espinosa, Martí Pumarola, Ester Blasco Ortega, Jaume Alomar, Koen Santifort, Koen Santifort, Steven De Decker, Karol Lam, Juan José Mínguez, Patricia Álvarez, Vicente Aige-Gil   +11 more
doaj   +1 more source

Transnasal endoscopic surgery of sphenoid meningocele associated with pituitary adenoma. A case report

Biomedical Papers, 2022
Background. Transsphenoid meningoencephalocele is a congenital anomaly formed by herniation of an ependyma delimited sac through a bony defect into the sphenoid sinus. The sac contains cerebrospinal fluid and neurovascular structures.
Vlastimil Novak, Lumir Hrabalek, Jiri Hoza, Lucie Tuckova, Daniel Pohlodek   +4 more
doaj   +1 more source

STAID: A Self‐Refining Deep Learning Framework for Spatial Cell‐Type Deconvolution with Biologically Informed Modeling

Advanced Science, EarlyView.
STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu, Shuli Sun, Zhengliang Lv, Xinyu Liu, Yihua Wang, Bingqiang Liu   +5 more
wiley   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

T cells can mediate viral clearance from ependyma but not from brain parenchyma in a major histocompatibility class I- and perforin-independent manner

Brain : a journal of neurology, 2010
Viral infection of the central nervous system can lead to disability and death. Yet the majority of viral infections with central nervous system involvement resolve with only mild clinical manifestations, if any. This is generally attributed to efficient
D. Pinschewer, Mariann Schedensack, A. Bergthaler, Edit Horváth, W. Brück, M. Löhning, D. Merkler   +6 more
semanticscholar   +1 more source

The MacBrain Resource Center (MBRC) rhesus macaque embryonic brain histology datasets

Journal of Anatomy, EarlyView.
We introduce the MacBrain Resource Center (MBRC) Collections of rhesus macaque embryonic brain tissue. Here, we illustrate histo‐ and immunohistology from our dynamically growing Collection 6, which currently contains >10,000 zoomable and downloadable images from n = 14 male and female embryos from early to late in gestation.
Valeria Mendoza‐Silva, Emma Burke, Lucy Greene, Mikhail Rodov, Janja Kopić, Phil Barello, Yury M. Morozov, Keiko Moriya‐Ito, Chiaki Ohtaka‐Maruyama, Zeljka Krsnik, Pasko Rakic, Alvaro Duque   +11 more
wiley   +1 more source

In utero ventriculosubgaleal shunt placement in a fetal lamb model: Phase 1 technical insights

Pregnancy, Volume 2, Issue 4, July 2026.
Abstract Background Progressive ventriculomegaly and the resulting irreversible brain damage may be mitigated through timely diversion prenatal intervention. While ventriculosubgaleal shunt (VSGS) is commonly performed postnatally in premature infants, in utero placement is unexplored.
Shohra Qaderi, Weston T. Northam, Soner Duru, Eyal Krispin, Nikan Zargarzadeh, Ali Javinani, Jose L. Peiro, Hamidreza Forourtan, Braxton Forde, Syril James, Scott A. Shainker, Arthur Nedder, Brittany Pattison, Lana Vasung, Lucas Peiro, Ryne A. Didier, Michaela K. Farber, Sebastian Seifert, Darren B. Orbach, P. Ellen Grant, Ramen H. Chmait, Benjamin C. Warf, Kjersti Aagaard, Yves Ville, Alireza A. Shamshirsaz   +24 more
wiley   +1 more source

Welfare and Physiological Consequences of Non‐Lethal Blood Sampling From the Caudal Vasculature of Atlantic Salmon (Salmo salar L.)

Journal of Fish Diseases, Volume 49, Issue 7, July 2026.
ABSTRACT The objective of this study was to evaluate welfare and health effects following single and repeated non‐lethal blood sampling from the caudal vasculature of Atlantic salmon. Two experiments were conducted at three different temperatures: a 6‐week freshwater experiment with fish weighing 50–100 g, undergoing up to four blood withdrawals, and a
Harriet Romstad, Camilla Karlsen, Silje Stensby‐Skjærvik, Alf Seljenes Dalum, Maria Banaszkiewicz, Simen Foyn Nørstebø, Jessica Louise Ray, Hege Lund, Torstein Kristensen, Christine Klykken   +9 more
wiley   +1 more source

Targeting choroid plexus epithelia and ventricular ependyma for drug delivery to the central nervous system

BMC Neuroscience, 2011
BackgroundBecause the choroid plexus (CP) is uniquely suited to control the composition of cerebrospinal fluid (CSF), there may be therapeutic benefits to increasing the levels of biologically active proteins in CSF to modulate central nervous system ...
A. González, W. Leadbeater, M. Burg, K. Sims, T. Terasaki, C. Johanson, E. Stopa, B. Eliceiri, A. Baird   +8 more
semanticscholar   +1 more source