Results 41 to 50 of about 6,283 (202)

Overuse injury induces persistent behavioral declines that correlate with higher IL-6 expression in the affected musculoskeletal tissues, circulation, and brain

Frontiers in Physiology
BackgroundPain and sickness behaviors can be elicited by systemic inflammation. We sought to determine if mature rats displayed these behaviors following overuse injury and whether they correlated with inflammatory cytokines in musculoskeletal tissues ...
Mary F. Barbe, Alex G. Lambi, Michele Y. Harris, Parth R. Patel, Istvan P. Tamas, Elizabeth R. McGonagle, Megan Van Der Bas, Betsy A. Kalicharan, Lewis Bright-Rowe, Steven N. Popoff, David M. Klyne   +10 more
doaj   +1 more source

STAID: A Self‐Refining Deep Learning Framework for Spatial Cell‐Type Deconvolution with Biologically Informed Modeling

Advanced Science, Volume 13, Issue 43, 3 August 2026.
STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu, Shuli Sun, Zhengliang Lv, Xinyu Liu, Yihua Wang, Bingqiang Liu   +5 more
wiley   +1 more source

The Ependyma of the Cat Central Canal, with Particular Reference to its Mitochondria-Containing Bulbs [PDF]

, 1984
The ultrastructure of the ependyma in the central canal of adult cats was examined in both the scanning and the transmission electron microscopes (SEM and TEM).
Nacimiento, A. C., Booz, K. H., Rascher, K., Donauer, E.   +3 more
core   +1 more source

Single‐cell atlas of neuroglial dynamics in SNCA‐A53T Parkinson's disease mouse model

Animal Models and Experimental Medicine, Volume 9, Issue 8, Page 1613-1632, August 2026.
We performed single‐cell RNA sequencing of midbrain and striatal tissues from SNCA‐A53T Parkinson's disease (PD) mice, revealing glia‐enriched PD‐risk gene signatures and disease‐specific subpopulations. Transcriptional dysregulation of key TFs (e.g., Rorb, Foxc1) and enhanced neuroinflammatory signaling (SEMA, CCL, MIF) were identified.
Binqing Qin, Zichu Fu, Xuanxuan Zou, Senmao Chai, Jingjing Weng, Puqing Wang, Xiaodong Sun, Ming Sang   +7 more
wiley   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, Volume 104, Issue 5, Page e478-e490, August 2026.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Iron homeostasis and post-hemorrhagic hydrocephalus: a review

Frontiers in Neurology
Iron physiology is regulated by a complex interplay of extracellular transport systems, coordinated transcriptional responses, and iron efflux mechanisms.
Shelei Pan, Andrew T. Hale, Mackenzie E. Lemieux, Dhvanii K. Raval, Thomas P. Garton, Brooke Sadler, Brooke Sadler, Kelly B. Mahaney, Jennifer M. Strahle, Jennifer M. Strahle, Jennifer M. Strahle   +10 more
doaj   +1 more source

In utero ventriculosubgaleal shunt placement in a fetal lamb model: Phase 1 technical insights

Pregnancy, Volume 2, Issue 4, July 2026.
Abstract Background Progressive ventriculomegaly and the resulting irreversible brain damage may be mitigated through timely diversion prenatal intervention. While ventriculosubgaleal shunt (VSGS) is commonly performed postnatally in premature infants, in utero placement is unexplored.
Shohra Qaderi, Weston T. Northam, Soner Duru, Eyal Krispin, Nikan Zargarzadeh, Ali Javinani, Jose L. Peiro, Hamidreza Forourtan, Braxton Forde, Syril James, Scott A. Shainker, Arthur Nedder, Brittany Pattison, Lana Vasung, Lucas Peiro, Ryne A. Didier, Michaela K. Farber, Sebastian Seifert, Darren B. Orbach, P. Ellen Grant, Ramen H. Chmait, Benjamin C. Warf, Kjersti Aagaard, Yves Ville, Alireza A. Shamshirsaz   +24 more
wiley   +1 more source

The Distributional Nexus of Choroid Plexus to Cerebrospinal Fluid, Ependyma and Brain

, 2010
Bordering the ventricular cerebrospinal fluid (CSF) are epithelial cells of choroid plexus (CP), ependyma and circumventricular organs (CVOs) that contain homeostatic transporters for mediating secretion/reabsorption. The distributional pathway (“nexus”)
Daniel Roth, Paul McMillan, Georg Krinke, Edward Stopa, Conrad Johanson, Juergen Funk   +5 more
core   +1 more source

Primary cell and tissue cultures of human choroid plexus epithelial cells

Frontiers in Cellular Neuroscience
Choroid plexus epithelial cells (CPEC) are implicated in cerebrospinal fluid (CSF) production and the site of the inner blood-cerebrospinal fluid barrier.
Ronja Bihlmaier, Melanie Scharr, Peter H. Neckel, Bernhard Hirt, Andreas F. Mack   +4 more
doaj   +1 more source

Welfare and Physiological Consequences of Non‐Lethal Blood Sampling From the Caudal Vasculature of Atlantic Salmon (Salmo salar L.)

Journal of Fish Diseases, Volume 49, Issue 7, July 2026.
ABSTRACT The objective of this study was to evaluate welfare and health effects following single and repeated non‐lethal blood sampling from the caudal vasculature of Atlantic salmon. Two experiments were conducted at three different temperatures: a 6‐week freshwater experiment with fish weighing 50–100 g, undergoing up to four blood withdrawals, and a
Harriet Romstad, Camilla Karlsen, Silje Stensby‐Skjærvik, Alf Seljenes Dalum, Maria Banaszkiewicz, Simen Foyn Nørstebø, Jessica Louise Ray, Hege Lund, Torstein Kristensen, Christine Klykken   +9 more
wiley   +1 more source