Results 11 to 20 of about 4,605 (161)

Toll-like receptor 4 agonist and antagonist lipopolysaccharides modify innate immune response in rat brain circumventricular organs [PDF]

Journal of Neuroinflammation, 2020
Background The circumventricular organs (CVOs) are blood-brain-barrier missing structures whose activation through lipopolysaccharide (LPS) is a starting point for TLR-driven (Toll-like receptors) neuroinflammation.
Alejandra Vargas-Caraveo, Aline Sayd, Javier Robledo-Montaña, Javier R. Caso, José L. M. Madrigal, Borja García-Bueno, Juan C. Leza   +6 more
doaj   +2 more sources

New aspects of fenestrated vasculature and tissue dynamics in the sensory circumventricular organs of adult brains [PDF]

Frontiers in Neuroscience, 2015
The blood–brain barrier (BBB) generally consists of endothelial tight junction barriers that prevent the free entry of blood-derived substances, thereby maintaining the extracellular environment of the brain. However, the circumventricular organs (CVOs),
Seiji eMiyata
doaj   +2 more sources

Sensory Circumventricular Organ Insulin Signaling in Cardiovascular and Metabolic Regulation [PDF]

Current Issues in Molecular Biology
Central nervous system (CNS) insulin signaling is involved in a broad array of cardiometabolic physiology, including glucose and lipid metabolism, feeding, energy expenditure, and blood pressure regulation.
Han Rae Kim, Jin Kwon Jeong, Colin N. Young   +2 more
doaj   +2 more sources

The Dark Pituitary: Hemochromatosis as a Lesser-Known Cause of Pituitary Dysfunction

Journal of the Belgian Society of Radiology, 2022
Teaching Point: Iron deposition in the pituitary gland in patients with primary and secondary hemochromatosis is a lesser-known cause of pituitary dysfunction and results in T2- and T2*-signal loss on MRI, other brain structures, in which iron deposition
Bert Verberckmoes, Sven Dekeyzer, Karen Decaestecker   +2 more
doaj   +1 more source

Constitutively active microglial populations limit anorexia induced by the food contaminant deoxynivalenol

Journal of Neuroinflammation, 2022
Microglia are involved in neuroinflammatory processes during diverse pathophysiological conditions. To date, the possible contribution of these cells to deoxynivalenol (DON)-induced brain inflammation and anorexia has not yet been evaluated.
Stéphanie Gaige, Rym Barbouche, Manon Barbot, Sarah Boularand, Michel Dallaporta, Anne Abysique, Jean-Denis Troadec   +6 more
doaj   +1 more source

The circumventricular organs.

Histology and histopathology, 2017
The circumventricular organs (CVOs) are midline structures located around the third and fourth ventricles that are characterized by a lack of blood-brain barrier. The pineal gland, median eminence, neurohypophysis and the subcommisural organ are classified as secretory, whereas the subfornical organ, area postrema and the organum vasculosum of the ...
Kaur, Charanjit, Ling, Eng Ang
openaire   +3 more sources

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents. [PDF]

Brain Behav
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Lawrence E, Fulton D, Brown P, Suresh S, Morris M, Goggolidou P, Chaithanya S, Abbawy M, Wild A, Nasa P, Duggal NA, Gao-Smith F, Ahmed Z, Renukappa S, Veenith T.   +14 more
europepmc   +2 more sources

The neuroactive neurosteroid Dehydroepiandrosterone Sulfate (DHEAS) modulates the serotonergic system within the dorsal Raphe nucleus and the cerebrospinal fluid release of Reissner’s fiber in rat

Comptes Rendus Biologies, 2020
Dehydroepiandrosterone sulfate (DHEAS) exerts important functions in the nervous system, such as modulation of neuronal death, brain development, cognition and behavior.
El Hiba, Omar, Draoui, Ahmed, Gamrani, Halima   +2 more
doaj   +1 more source

LPS Primes Brain Responsiveness to High Mobility Group Box-1 Protein

Pharmaceuticals, 2021
High mobility group box (HMGB)1 action contributes to late phases of sepsis, but the effects of increased endogenous plasma HMGB1 levels on brain cells during inflammation are unclear.
Verena Peek, Lois M. Harden, Jelena Damm, Ferial Aslani, Stephan Leisengang, Joachim Roth, Rüdiger Gerstberger, Marita Meurer, Maren von Köckritz-Blickwede, Sabine Schulz, Bernhard Spengler, Christoph Rummel   +11 more
doaj   +1 more source

IMMUNOHISTOCHEMICAL EXPRESSION OF MONOCARBOXYLATE TRANSPORTER 1&4 IN TANYCYTE–LIKE CELLS OF THE SULCUS MEDIANUS ORGANUM

The Iraqi Journal of Medical Sciences, 2019
Background: Circumventricular organs (CVOs) are specialized structures border the brain ventricles and lack the blood-brain barrier. These CVOs are lined by specialized ependymal cells (ECs) called tanycyte.
Haider F. Jawad, Muthanna A. Al-Kaabi, Anam R. Al-Salihi   +2 more
doaj   +6 more sources