GPIHBP1, lipoprotein lipase, and triglyceride-rich lipoproteins in capillaries of the choroid plexus and circumventricular organs [PDF]
The Journal of Clinical InvestigationIn peripheral tissues, an endothelial cell (EC) protein, GPIHBP1, captures lipoprotein lipase (LPL) from the interstitial spaces and transports it to the capillary lumen.
Wenxin Song +25 more
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New aspects of fenestrated vasculature and tissue dynamics in the sensory circumventricular organs of adult brains [PDF]
Frontiers in Neuroscience, 2015 The blood–brain barrier (BBB) generally consists of endothelial tight junction barriers that prevent the free entry of blood-derived substances, thereby maintaining the extracellular environment of the brain. However, the circumventricular organs (CVOs),
Seiji eMiyata
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The circumventricular organs. [PDF]
Histology and histopathology, 2017 The circumventricular organs (CVOs) are midline structures located around the third and fourth ventricles that are characterized by a lack of blood-brain barrier. The pineal gland, median eminence, neurohypophysis and the subcommisural organ are classified as secretory, whereas the subfornical organ, area postrema and the organum vasculosum of the ...
Kaur, Charanjit, Ling, Eng Ang
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The origins of the circumventricular organs
Journal of Anatomy, 2017 Abstract The circumventricular organs (CVOs) are specialised neuroepithelial structures found in the midline of the brain, grouped around the third and fourth ventricles. They mediate the communication between the brain and the periphery by performing sensory and secretory roles, facilitated by increased vascularisation and the ...
Kiecker, Clemens, Clemens Kiecker
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Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging [PDF]
Frontiers in Aging NeuroscienceEffective communication between the brain and peripheral tissues is crucial for homeostasis and health, and its impairment is a defining feature of aging. Circumventricular organs, characterized by the presence of fenestrated capillaries and absence of a
Viana Q. Pham +6 more
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The circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitis [PDF]
Cerebrospinal Fluid Research, 2005 Background During inflammatory conditions of the central nervous system (CNS), such as in multiple sclerosis or in its animal model, experimental autoimmune encephalomyelitis (EAE), immune cells migrate from the blood stream into the CNS parenchyma and ...
Engelhardt Britta, Schulz Martina
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Sensory Circumventricular Organ Insulin Signaling in Cardiovascular and Metabolic Regulation
Current Issues in Molecular BiologyCentral nervous system (CNS) insulin signaling is involved in a broad array of cardiometabolic physiology, including glucose and lipid metabolism, feeding, energy expenditure, and blood pressure regulation.
Han Rae Kim +2 more
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Keeping time in the lamina terminalis: Novel oscillator properties of forebrain sensory circumventricular organs. [PDF]
FASEB J, 2020 Drinking behaviour and osmotic regulatory mechanisms exhibit clear daily variation which is necessary for achieving homeostatic osmolality. In mammals, the master clock in the brain’s suprachiasmatic nuclei (SCN) has long been held as the main driver of ...
Northeast RC +4 more
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Norepinephrine Inhibits Lipopolysaccharide-Stimulated TNF-α but Not Oxylipin Induction in n-3/n-6 PUFA-Enriched Cultures of Circumventricular Organs. [PDF]
Int J Mol Sci, 2022 Sensory circumventricular organs (sCVOs) are pivotal brain structures involved in immune-to-brain communication with a leaky blood–brain barrier that detect circulating mediators such as lipopolysaccharide (LPS).
Pflieger FJ +8 more
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SGLT2 gene expression in thirst-promoting NOS1 neurons and vasopressin-synthesizing neurons in male rats. [PDF]
Physiol RepAbstract While sodium–glucose cotransporter 2 (SGLT2) inhibitors exert diuretic effects, they cause only mild changes in body fluid balance, partly through compensatory increases in water intake and vasopressin (AVP) secretion. However, whether SGLT2 inhibitors directly influence central pathways governing these fluid‐regulatory responses remains ...
Masuda T +6 more
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