Anatomical Organization of the Rat Subfornical Organ [PDF]
Frontiers in Cellular Neuroscience, 2021 The subfornical organ (SFO) is a sensory circumventricular organ located along the anterodorsal wall of the third ventricle. SFO lacks a complete blood-brain barrier (BBB), and thus peripherally-circulating factors can penetrate the SFO parenchyma. These
Amirah-Iman Hicks +4 more
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Cellular Profile of Subfornical Organ Insulin Receptors in Mice [PDF]
BiomoleculesBrain insulin receptor signaling is strongly implicated in cardiovascular and metabolic physiological regulation. In particular, we recently demonstrated that insulin receptors within the subfornical organ (SFO) play a tonic role in cardiovascular and ...
Han-Rae Kim +2 more
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The transcriptome of the rat subfornical organ is altered in response to early postnatal overnutrition [PDF]
IBRO Reports, 2018 Early postnatal overnutrition in humans is associated with long-term negative outcomes including obesity, increased risk of type-II diabetes, and cardiovascular disease.
Colleen S. Peterson +4 more
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Increased apelin receptor gene expression in the subfornical organ of spontaneously hypertensive rats. [PDF]
PLoS ONE, 2020 The vascular organ of the lamina terminalis, subfornical organ (SFO), and area postrema comprise the sensory circumventricular organs (CVO) which are central structures that lie outside the blood brain barrier and are thought to provide an interface ...
Philip R Griffiths +5 more
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Salt-induced phosphoproteomic changes in the subfornical organ in rats with chronic kidney disease [PDF]
Renal Failure, 2023 Objectives Subfornical organ (SFO) is vital in chronic kidney disease (CKD) progression caused by high salt levels. The current study investigated the effects of high salt on phosphoproteomic changes in SFO in CKD rats.Methods 5/6 nephrectomized rats ...
Xin Wang +5 more
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The organum vasculosum of the lamina terminalis and subfornical organ: regulation of thirst [PDF]
Frontiers in Neuroscience, 2023 Thirst and water intake are regulated by the organum vasculosum of the lamina terminalis (OVLT) and subfornical organ (SFO), located around the anteroventral third ventricle, which plays a critical role in sensing dynamic changes in sodium and water ...
Jiaxu Wang +6 more
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Renin-a in the Subfornical Organ Plays a Critical Role in the Maintenance of Salt-Sensitive Hypertension [PDF]
Biomolecules, 2022 The brain renin-angiotensin system plays important roles in blood pressure and cardiovascular regulation. There are two isoforms of prorenin in the brain: the classic secreted form (prorenin/sREN) encoded by renin-a, and an intracellular form (icREN ...
Silvana G. Cooper +6 more
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Case report: Psychosis and catatonia in an adolescent patient with adipsic hypernatremia and autoantibodies against the subfornical organ [PDF]
Frontiers in Psychiatry, 2023 This is the first description of a patient in which adipsic hypernatremia, a rare autoimmune encephalitis, presented in combination with complex psychiatric symptomatology, including psychosis and catatonia.
Matthias Liebrand +13 more
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Neuropeptide Y modulates the electrical activity of subfornical organ neurons [PDF]
Current Research in NeurobiologyThe subfornical organ (SFO) is a sensory circumventricular organ, lacking a blood-brain barrier. It is well-recognized as a key center for detection and integration of osmotic, ionic and hormonal signals for maintenance of hydromineral balance and ...
Lauren Shute, Mark Fry
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Accumulation of prosaposin and progranulin around the subfornical organ induces polydipsia in SAP-D-deficient mice [PDF]
Biochemistry and Biophysics ReportsProsaposin (PSAP), a precursor of saposins, is essential for lysosomal hydrolysis of sphingolipids. It binds with progranulin (PGRN) and transports from the Golgi to lysosomes, where it is processed into saposins.
Harumi Hisaki +9 more
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