Results 41 to 50 of about 608,087 (203)

Autoimmunity related to anti-Nax and anti-ZSCAN1 autoantibodies in adipsic hypernatremia

Endocrine Journal
“Adipsic hypernatremia” is clinically characterized by chronic elevation of plasma [Na+] with an inappropriate lack of thirst and upward resetting of the osmotic set point for arginine vasopressin (AVP) secretion, combined with a relative deficiency of ...
Akari Nakamura-Utsunomiya
doaj   +1 more source

Neuroanatomical organization and functional roles of PVN MC4R pathways in physiological and behavioral regulations

Molecular Metabolism, 2022
Objective: The paraventricular nucleus of hypothalamus (PVN), an integrative center in the brain, orchestrates a wide range of physiological and behavioral responses.
Uday Singh, Jingwei Jiang, Kenji Saito, Brandon A. Toth, Jacob E. Dickey, Samuel R. Rodeghiero, Yue Deng, Guorui Deng, Baojian Xue, Zhiyong Zhu, Leonid V. Zingman, Joel C. Geerling, Huxing Cui   +12 more
doaj   +1 more source

Network Biology: Current Status, Applications, Challenges, and Future Prospects

MedComm, Volume 7, Issue 10, October 2026.
Network biology integrates molecular interaction, intracellular regulatory, single‐cell and multicellular, microbial and host–microbiome, disease, and interorgan networks across biological scales. Perturbation models, multiomics, spatial profiling, computational inference, mechanistic modeling, and AI enable dynamic network reconstruction and causal ...
Xinmeng Li, Laizhong Zhang, Yawen Ding, Kai Li, Shiyuan Chang, Linsen Pei, Zhengwei Li, Zhenzhen Chen   +7 more
wiley   +1 more source

A symmetric systemic challenge elicits a right‐biased response mediated by vasopressin signaling

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Water deprivation, a spatially symmetric homeostatic challenge, induces vasopressin receptor‐dependent right‐sided hindlimb asymmetry in rats, providing a binary readout of lateralized physiological regulation. These findings suggest that symmetric homeostatic challenges can engage neuroendocrine mechanisms that shift the balance between left‐ and ...
Hiroyuki Watanabe, Yaromir Kobikov, Sara Yusuf Mohamed, Karen Rich, Daniil Sarkisyan, Olga Nosova, Alfhild Grönbladh, Mathias Hallberg, Jens Schouenborg, Georgy Bakalkin, Mengliang Zhang   +10 more
wiley   +1 more source

Expression of certain proteins in the subfornical organ and cerebrospinal fluid of spontaneously hypertensive rats [PDF]

, 2007
The objective of this study was to analyze the proteins in the cerebrospinal fluid of spontaneously hypertensive rats and to study their possible role in the relationship between hydrocephalus, arterial hypertension and variations in the subfornical ...
Castañeyra-Ruíz, L., Castañeyra-Ruiz, A., Ormazabal-Ramos, C., Fernández-Rodríguez, P., Perez-Garcia, C.G., Pérez-González, H., Gonzalez-Marrero, I., Castañeyra Perdomo, A., Martínez de la Peña y Valenzuela, Isabel, Ferres Torres, R., Carmona-Calero, E.   +10 more
core  

Interaction between the septal area and the subfornical organ in the control of water intake induced by thirst-eliciting procedures

, 1980
Rats bearing lesions in the septal area followed by lesions in the subfornical organ were submitted to various thirst-eliciting procedures. The rats with hyperdipsia induced by lesions of the septal area drank more water than either during the control ...
Silva Neto, C. R., Covian, M. R., Camargo, L. A A [UNESP], Camargo, L. A A, Silva Neto, C. R. [UNESP], Covian, M. R. [UNESP], Antunes-Rodrigues, J., Morita, Norihiro [UNESP], Antunes-Rodrigues, J. [UNESP], Morita, Norihiro, Saad, W. A. [UNESP], Saad, W. A., Morita, N., Silvaneto, C. R., Camargo, LAA, Antunesrodrigues, J.   +15 more
core   +1 more source

Subfornical organ stimulation excites paraventricular neurons projecting to dorsal medulla

, 1984
Electrical stimulation in the subfornical organ (SFO) of pentobarbital-anesthetized Sprague-Dawley rats was noted to influence the excitability of paraventricular nucleus (PVN) neurons antidromically identified as projecting to the dorsomedial medulla ...
LP Renaud (15885317), AV Ferguson (15885332), TA Day (15885308)   +2 more
core   +3 more sources

SGLT2 gene expression in thirst‐promoting NOS1 neurons and vasopressin‐synthesizing neurons in male rats

Physiological Reports, Volume 14, Issue 17, September 2026.
Abstract While sodium–glucose cotransporter 2 (SGLT2) inhibitors exert diuretic effects, they cause only mild changes in body fluid balance, partly through compensatory increases in water intake and vasopressin (AVP) secretion. However, whether SGLT2 inhibitors directly influence central pathways governing these fluid‐regulatory responses remains ...
Takahiro Masuda, Masahide Yoshida, Young Chul Kim, Volker Vallon, Yoshiyuki Morishita, Daisuke Nagata, Tatsushi Onaka   +6 more
wiley   +1 more source

Water deprivation upregulates ANG II AT1 binding and mRNA in rat subfornical organ and anterior pituitary

, 1997
We studied angiotensin II (ANG II) receptor subtype expression in selected brain nuclei and pituitary gland after water deprivation by in vitro receptor autoradiography using 125I-labeled [Sar1]ANG II and by in situ hybridization using 35S-labeled AT1A,
W. Hauser, O. Johren, G. L. Sanvitto, J. M. Saavedra   +3 more
core   +1 more source

Circumventing a broken heart: cytokines and the subfornical organ [PDF]

American Journal of Physiology-Heart and Circulatory Physiology, 2017
heart failure is a growing epidemic in developed nations. According to the most recent figures from the Centers for Disease Control and Prevention and the 2016 statistical update from the American Heart Association, it is estimated that ~1.8% of the United States population, ~5.8 million adults,
Song T. Yao, Michael J. McKinley, Clive N. May   +2 more
openaire   +2 more sources