Results 61 to 70 of about 608,087 (203)

Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis

Molecular Metabolism, 2015
Objective: Elevations in brain angiotensin-II cause increased energy expenditure and a lean phenotype. Interestingly, the metabolic effects of increased brain angiotensin-II mimic the actions of leptin, suggesting an interaction between the two systems ...
Colin N. Young, Donald A. Morgan, Scott D. Butler, Kamal Rahmouni, Susan B. Gurley, Thomas M. Coffman, Allyn L. Mark, Robin L. Davisson   +7 more
doaj   +1 more source

Optogenetic stimulation of the median preoptic nucleus: Effects on hypothalamic paraventricular nucleus magnocellular neurons after chronic intermittent hypoxia exposure

Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.
Abstract Median preoptic nucleus (MnPO) neurons projecting to the hypothalamic paraventricular nucleus (PVN) are linked to hypertension induced by chronic intermittent hypoxia (CIH), a model of obstructive sleep apnea. The modulation of MnPO‐driven synaptic activity in PVN magnocellular neurons (MNCs) by CIH remains unexamined.
Obed T. Paundralingga, Shuping Jia, George E. Farmer Jr, Glenn M. Toney, J. Thomas Cunningham   +4 more
wiley   +1 more source

Interpreting Anxiety Disorders From the Perspective of Interoceptive Computational Models

Brain and Behavior, Volume 15, Issue 12, December 2025.
Pathological anxiety stems from computational failures in interoception, where rigid threat beliefs amplify prediction errors. This review outlines how these mechanisms sustain maladaptive behaviors and cognitive biases. We synthesize a path forward by integrating computational models with targeted interventions to recalibrate this dysregulated process
Zihan Lin, Shiqi Liao, Shasha Zhu, Yuqing Zhao, Wen‐Jing Yan, Ke Jiang, Kaiyu Qiu   +6 more
wiley   +1 more source

Cellular mechanisms of long‐term osmoregulation in magnocellular neurons

Journal of Neuroendocrinology, Volume 37, Issue 12, December 2025.
Abstract Osmoregulation is an essential homeostatic process that maintains the osmolality of the extracellular fluid (ECF) close to a physiological setpoint. Vasopressin (VP) plays a key role in osmoregulation and is secreted by the magnocellular neurosecretory cells (MNCs) of the hypothalamus.
Kirk D. Haan, Thomas E. Fisher
wiley   +1 more source

Control of fluid intake by estrogens in the female rat: role of the hypothalamus

Frontiers in Systems Neuroscience, 2015
Body fluid homeostasis is maintained by a complex network of central and peripheral systems that regulate blood pressure, fluid and electrolyte excretion, and fluid intake.
Jessica eSantollo, Derek eDaniels
doaj   +1 more source

Mechanisms of intrinsic osmolality and sodium detection by magnocellular neurosecretory neurons

Journal of Neuroendocrinology, Volume 37, Issue 12, December 2025.
Abstract The maintenance of extracellular fluid (ECF) osmolality and sodium concentration ([Na+]o) near optimal “set point” values sustains physiological functions and prevents pathological states such as hypo‐ and hypernatremia. The peptide hormones vasopressin (antidiuretic hormone) and oxytocin (a natriuretic hormone in rats) play key roles in this ...
Sandra Salgado‐Mozo, Anzala Murtaz, Joshua C. Wyrosdic, Julie O'Reilly‐Fong, Cristian Zaelzer, Mary P. LaPierre, Charles W. Bourque   +6 more
wiley   +1 more source

Dehydration and cognition in geriatrics: a hydromolecular hypothesis

Frontiers in Molecular Biosciences, 2016
Dehydration is one of the ten most frequent diagnoses responsible for the hospital admission of elderly in the United States. It is associated with increased mortality, morbidity and an estimated cost of 1.14 billion per year (1-4).
Adonis eSfera, Adonis eSfera, Michael eCummings, Carolina eOsorio   +3 more
doaj   +1 more source

Central Osmolality Sensing for Arginine Vasopressin Release Is Mediated by WNK1‐OSR1/SPAK‐Kv3.1 Cascade

The FASEB Journal, Volume 39, Issue 22, 30 November 2025.
Extracellular hyperosmolality extracts water from the catalytic center of WNK1 increasing the kinase activity. WNK1 phosphorylates and activates OSR1/SPAK leading to increases in Kv3.1 activity. Enhanced Kv3.1 activity accelerates repolarization, increasing afterhyperpolarization (AHP) and/or shortening AP width to increase action potential firing ...
Xin Jin, Jian Xie, Chia‐Wei Yeh, Yu‐Jui Li, Cheng‐Chang Lien, Chou‐Long Huang   +5 more
wiley   +1 more source

Synaptic and Non‐Synaptic Functions of PTPRD: A Receptor Tyrosine Phosphatase at the Crossroads of Neural Circuitry and Metabolism

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
PTPRD (receptor‐type protein tyrosine phosphatase delta) translates extracellular adhesion “codes” into intracellular phosphotyrosine signaling that shapes brain circuits. Alternative inclusion of micro‐exons meA and meB sculpts PTPRD's Ig domain, dictating trans‐synaptic binding to partners such as IL1RAPL1 or IL1RAP and thereby tuning synapse ...
Seoyeong Kim, Jae Jin Shin, Muwon Kang, Yunho Yi, Eunjoon Kim   +4 more
wiley   +1 more source

Plasma apolipoproteins and memory function in alcohol use disorder: Findings in male C57BL/6J mice and men suggest a role for APOAI

Alcohol, Clinical and Experimental Research, Volume 49, Issue 10, Page 2278-2293, October 2025.
Both alcohol‐dependent mice and abstinent AUD patients exhibited elevated plasma APOAI levels and memory impairments compared to controls. Higher APOAI levels were associated with poorer memory in both species, suggesting its potential as a biomarker for alcohol‐related cognitive deficits.
Berta Escudero, Max Kreifeldt, Kiera Fleck, Catherine Lopez, Candice Contet, Laura Orio   +5 more
wiley   +1 more source