Results 61 to 70 of about 3,372 (201)

Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis

Molecular Metabolism, 2015
Objective: Elevations in brain angiotensin-II cause increased energy expenditure and a lean phenotype. Interestingly, the metabolic effects of increased brain angiotensin-II mimic the actions of leptin, suggesting an interaction between the two systems ...
Colin N. Young, Donald A. Morgan, Scott D. Butler, Kamal Rahmouni, Susan B. Gurley, Thomas M. Coffman, Allyn L. Mark, Robin L. Davisson   +7 more
doaj   +1 more source

Central administered xenin induced Fos expression in nesfatin-1 neurons in rats

Brain Research Bulletin, 2023
Xenin is a 25-amino acid peptide identified in human gastric mucosa, which is widely expressed in peripheral and central tissues. It is known that the central or peripheral administration of xenin decreases food intake in rodents.
Shota Saito, Hirofumi Hashimoto, Hidefumi Wakashin, Misaki Ishibane, Sangjon Pae, Shinpei Saito, Yoshie Reien, Yuri Hirayama, Yoshiteru Seo, Takashi Mizushima, Naohiko Anzai   +10 more
doaj   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, Volume 3, Issue 3, September 2025.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury

Advanced Science, Volume 12, Issue 31, August 21, 2025.
Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley   +1 more source

Central regulation of drinking water in divergently selected high‐water‐efficient young broiler chickens: A minireview

Journal of Neuroendocrinology, Volume 37, Issue 6, June 2025.
Abstract Poultry production is confronting real challenges, including a lofty projected high demand for animal proteins to feed the future, and the need to adapt to planetary boundaries (global warming) with limited natural resources (land, energy, water).
Brooklee Roach, Elizabeth S. Greene, Sami Dridi   +2 more
wiley   +1 more source

Control of fluid intake by estrogens in the female rat: role of the hypothalamus

Frontiers in Systems Neuroscience, 2015
Body fluid homeostasis is maintained by a complex network of central and peripheral systems that regulate blood pressure, fluid and electrolyte excretion, and fluid intake.
Jessica eSantollo, Derek eDaniels
doaj   +1 more source

Tau Pathology Drives Disease‐Associated Astrocyte Reactivity in Salt‐Induced Neurodegeneration

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This study reveals that a high‐salt diet (HSD) induces enhanced reactivity of DAA‐like astrocytes in the hippocampal CA3 region via a tau pathology‐A1R signaling axis, forming a vicious cycle that perpetuates astrocyte reactivity. Neuronal tau pathology releases PAPDs, notably Lcn2, driving neuroinflammation.
Tong‐Yu Rui, He‐Zhou Huang, Kai Zheng, Hong‐Wei Fan, Juan Zhang, Zi‐Yuan Guo, Heng‐Ye Man, Nadezhda Brazhe, Alexey Semyanov, You‐Ming Lu, Dan Liu, Ling‐Qiang Zhu   +11 more
wiley   +1 more source

Dehydration and cognition in geriatrics: a hydromolecular hypothesis

Frontiers in Molecular Biosciences, 2016
Dehydration is one of the ten most frequent diagnoses responsible for the hospital admission of elderly in the United States. It is associated with increased mortality, morbidity and an estimated cost of 1.14 billion per year (1-4).
Adonis eSfera, Adonis eSfera, Michael eCummings, Carolina eOsorio   +3 more
doaj   +1 more source

Brainwide Projections of Mouse Dopaminergic Zona Incerta Neurons

Journal of Comparative Neurology, Volume 533, Issue 3, March 2025.
Cre‐dependent viral tracing from medial dopaminergic ZI neurons revealed abundant fiber projections rostrocaudally throughout the brain. Interestingly, the midbrain motor regions, including the periaqueductal gray area and superior colliculus, contained the densest accumulation of fiber projections, and this fiber density was independent of the region ...
Bianca S. Bono, Kenichiro Negishi, Yasmina Dumiaty, Monica S. Ponce‐Ruiz, Titilayo C. Akinbode, Kayla S. Baker, C. Duncan P. Spencer, Elizabeth Mejia, Marina Guirguis, Alex J. Hebert, Arshad M. Khan, Melissa J. Chee   +11 more
wiley   +1 more source

Understanding glucose metabolism and insulin action at the blood–brain barrier: Implications for brain health and neurodegenerative diseases

Acta Physiologica, Volume 241, Issue 2, February 2025.
Abstract The blood–brain barrier (BBB) is a highly selective, semipermeable barrier critical for maintaining brain homeostasis. The BBB regulates the transport of essential nutrients, hormones, and signaling molecules between the bloodstream and the central nervous system (CNS), while simultaneously protecting the brain from potentially harmful ...
Yiyi Zhu, Alexei Verkhratsky, Hui Chen, Chenju Yi   +3 more
wiley   +1 more source