Results 71 to 80 of about 3,372 (201)

Modulation of subfornical organ neurons by neurotensin

, 2023
Neurotensin (NT) is a 13 amino-acid peptide which is both a hormone and neuromodulator. Through its 3-4 known receptors, NT is shown to influence several physiological responses including autonomic output, hydromineral balance, and cardiovascular ...
Belyea, M Megan
core  

Nanoparticles Navigating the Intranasal Route: Innovative Approaches in Neurodegenerative Diseases

Journal of Nanotechnology, Volume 2025, Issue 1, 2025.
Intranasal drug delivery is emerging as a transformative strategy for treating neurodegenerative diseases, offering a noninvasive route that bypasses the limitations of the blood–brain barrier. This review provides a comprehensive analysis of the current landscape and challenges of intranasal drug delivery for neurodegenerative conditions with an ...
Fabiola V. Borbolla-Jiménez, Stephany Celeste Gutiérrez-Ruiz, Hector Hernández-Parra, Sheila I. Peña-Corona, Aura A. Tamez, Ricardo D. Rivas-Amores, Jonathan J. Magaña, Gerardo Leyva-Gomez, Nasrullah Jan   +8 more
wiley   +1 more source

Paediatric perspectives in the diagnosis of polyuria‐polydipsia syndrome

Clinical Endocrinology, Volume 101, Issue 6, Page 580-592, December 2024.
Abstract The elucidation of the underlying cause of polyuria‐polydipsia syndrome (PPS) is a challenging—especially in the differentiation of partial defects of arginine vasopressin (AVP) secretion or action from primary polydipsia. The water deprivation test has been utilized for many decades, and its application in the paediatric population has been ...
Tony Huynh, Dana Signal, Mirjam Christ‐Crain   +2 more
wiley   +1 more source

Effect of injection of L-NAME on drinking response

Brazilian Journal of Medical and Biological Research, 1999
The drinking behavior responses to centrally administered NG-nitro-L-arginine methyl ester (L-NAME; 10, 20 or 40 µg/µl), an inhibitor of nitric oxide synthase, were studied in satiated rats, with cannulae stereotaxically implanted into the lateral ...
W.A. Saad, L.A.A. Camargo, R. Saad, A.F. Pereira, S. Simões   +4 more
doaj   +1 more source

Recent advances in the characterization of genetically defined neurons that regulate internal‐state‐dependent taste modification in mice

Physiological Reports, Volume 12, Issue 21, November 2024.
Abstract The gustatory system plays an important role in evaluating food quality in animals and humans. While some tastes are intrinsically appetitive, such as sweet, which is elicited from high‐calorie nutrients, the other tastes, such as sour and bitter, are aversive and elicited by toxic substances.
Ken‐ichiro Nakajima
wiley   +1 more source

Interactions between kisspeptin and bone: Cellular mechanisms, clinical evidence, and future potential

Annals of the New York Academy of Sciences, Volume 1540, Issue 1, Page 47-60, October 2024.
The neuropeptide kisspeptin is a critical endogenous activator of the reproductive system. Notably, both kisspeptin and its receptor are expressed in the key bone cells, osteoblasts, and osteoclasts, suggesting direct bone effects. In this review, we examine the evidence derived from in vitro experiments through to in vivo and clinical studies ...
Edouard G. Mills, Ali Abbara, Waljit S. Dhillo, Alexander N. Comninos   +3 more
wiley   +1 more source

Brain sodium sensing for regulation of thirst, salt appetite, and blood pressure

Physiological Reports
The brain possesses intricate mechanisms for monitoring sodium (Na) levels in body fluids. During prolonged dehydration, the brain detects variations in body fluids and produces sensations of thirst and aversions to salty tastes.
Takeshi Y. Hiyama
doaj   +1 more source

Drinking and pressor responses after acetylcholine injection into subfornical organ

, 1983
Mean arterial pressure and drinking were measured in rats before and after intracranial injection of acetylcholine (ACh) into the subfornical organ (SFO), the circumventricular organ of the dorsal third ventricle.
M. L. Mangiapane, J. B. Simpson
core   +1 more source

Neuroimmune modulation for targeting organ damage in hypertension and atherosclerosis

The Journal of Physiology, Volume 602, Issue 19, Page 4789-4802, 1 October 2024.
Abstract figure legend Targeting the brain‐to‐spleen connection to reduce vascular damage in atherosclerosis and hypertension. The afferent and efferent arms of the circuit activated by pathological changes in atherosclerotic arteries are indicated in blue. The afferent and efferent arms of the circuit activated by hypertensive challenges are indicated
Marialuisa Perrotta, Daniela Carnevale
wiley   +1 more source

Gut Microbiota Affects Mouse Social Behavior via Hippuric Acid Metabolism

Neurology International
Background/Objectives: Autism spectrum disorder (ASD) is a neurodevelopmental disorder typically characterized by impaired social communication. Previous reports have postulated gut microbiota to be an important non-genetic factor affecting ASD-like ...
Momona Tsukui, Sosuke Yagishita, Shinji Tokunaga, Shuji Wakatsuki, Toshiyuki Araki   +4 more
doaj   +1 more source