Results 51 to 60 of about 3,372 (201)

Water deprivation upregulates ANG II AT1 binding and mRNA in rat subfornical organ and anterior pituitary

, 1997
We studied angiotensin II (ANG II) receptor subtype expression in selected brain nuclei and pituitary gland after water deprivation by in vitro receptor autoradiography using 125I-labeled [Sar1]ANG II and by in situ hybridization using 35S-labeled AT1A,
W. Hauser, O. Johren, G. L. Sanvitto, J. M. Saavedra   +3 more
core   +1 more source

Mechanisms of intrinsic osmolality and sodium detection by magnocellular neurosecretory neurons

Journal of Neuroendocrinology, Volume 37, Issue 12, December 2025.
Abstract The maintenance of extracellular fluid (ECF) osmolality and sodium concentration ([Na+]o) near optimal “set point” values sustains physiological functions and prevents pathological states such as hypo‐ and hypernatremia. The peptide hormones vasopressin (antidiuretic hormone) and oxytocin (a natriuretic hormone in rats) play key roles in this ...
Sandra Salgado‐Mozo, Anzala Murtaz, Joshua C. Wyrosdic, Julie O'Reilly‐Fong, Cristian Zaelzer, Mary P. LaPierre, Charles W. Bourque   +6 more
wiley   +1 more source

Structural defects in cilia of the choroid plexus, subfornical organ and ventricular ependyma are associated with ventriculomegaly

Fluids and Barriers of the CNS, 2012
Background Hydrocephalus is a heterogeneous disorder with multiple etiologies that are not yet fully understood. Animal models have implicated dysfunctional cilia of the ependyma and choroid plexus in the development of the disorder.
Swiderski Ruth E, Agassandian Khristofor, Ross Jean L, Bugge Kevin, Cassell Martin D, Yeaman Charles   +5 more
doaj   +1 more source

The proinflammatory cytokine tumor necrosis factor-α excites subfornical organ neurons.

J Neurophysiol, 2017
Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine implicated in cardiovascular and autonomic regulation via actions in the central nervous system.
Simpson NJ, Ferguson AV.
europepmc   +2 more sources

Circumventing a broken heart: cytokines and the subfornical organ [PDF]

American Journal of Physiology-Heart and Circulatory Physiology, 2017
heart failure is a growing epidemic in developed nations. According to the most recent figures from the Centers for Disease Control and Prevention and the 2016 statistical update from the American Heart Association, it is estimated that ~1.8% of the United States population, ~5.8 million adults,
Song T. Yao, Michael J. McKinley, Clive N. May   +2 more
openaire   +2 more sources

Interaction between the lateral preoptic area and the subfornical organ in the control of water ingestion caused by cellular dehydration, hypotension, hypovolemia, and deprivation

, 1980
Water intake was studied in albino rats with lesions in the lateral preoptic area, in the subfornical organ, and in both the lateral preoptic area and the subfornical organ.
Antonio de Arruda Camargo, L., Abrao Saad, W.   +1 more
core   +1 more source

Central Osmolality Sensing for Arginine Vasopressin Release Is Mediated by WNK1‐OSR1/SPAK‐Kv3.1 Cascade

The FASEB Journal, Volume 39, Issue 22, 30 November 2025.
Extracellular hyperosmolality extracts water from the catalytic center of WNK1 increasing the kinase activity. WNK1 phosphorylates and activates OSR1/SPAK leading to increases in Kv3.1 activity. Enhanced Kv3.1 activity accelerates repolarization, increasing afterhyperpolarization (AHP) and/or shortening AP width to increase action potential firing ...
Xin Jin, Jian Xie, Chia‐Wei Yeh, Yu‐Jui Li, Cheng‐Chang Lien, Chou‐Long Huang   +5 more
wiley   +1 more source

Synaptic and Non‐Synaptic Functions of PTPRD: A Receptor Tyrosine Phosphatase at the Crossroads of Neural Circuitry and Metabolism

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
PTPRD (receptor‐type protein tyrosine phosphatase delta) translates extracellular adhesion “codes” into intracellular phosphotyrosine signaling that shapes brain circuits. Alternative inclusion of micro‐exons meA and meB sculpts PTPRD's Ig domain, dictating trans‐synaptic binding to partners such as IL1RAPL1 or IL1RAP and thereby tuning synapse ...
Seoyeong Kim, Jae Jin Shin, Muwon Kang, Yunho Yi, Eunjoon Kim   +4 more
wiley   +1 more source

Sniffer cells for the detection of neural Angiotensin II in vitro

Scientific Reports, 2019
Neuropeptide release in the brain has traditionally been difficult to observe. Existing methods lack temporal and spatial resolution that is consistent with the function and size of neurons.
George E. Farmer, Anna Amune, Martha E. Bachelor, Phong Duong, Joseph P. Yuan, J. Thomas Cunningham   +5 more
doaj   +1 more source

Plasma apolipoproteins and memory function in alcohol use disorder: Findings in male C57BL/6J mice and men suggest a role for APOAI

Alcohol, Clinical and Experimental Research, Volume 49, Issue 10, Page 2278-2293, October 2025.
Both alcohol‐dependent mice and abstinent AUD patients exhibited elevated plasma APOAI levels and memory impairments compared to controls. Higher APOAI levels were associated with poorer memory in both species, suggesting its potential as a biomarker for alcohol‐related cognitive deficits.
Berta Escudero, Max Kreifeldt, Kiera Fleck, Catherine Lopez, Candice Contet, Laura Orio   +5 more
wiley   +1 more source