Results 11 to 20 of about 608,087 (203)

Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice [PDF]

eLife, 2019
The circumventricular organs (CVOs) in the central nervous system (CNS) lack a vascular blood-brain barrier (BBB), creating communication sites for sensory or secretory neurons, involved in body homeostasis.
Fabienne Benz, Viraya Wichitnaowarat, Martin Lehmann, Raoul FV Germano, Diana Mihova, Jadranka Macas, Ralf H Adams, M Mark Taketo, Karl-Heinz Plate, Sylvaine Guérit, Benoit Vanhollebeke, Stefan Liebner   +11 more
doaj   +3 more sources

A novel interoceptive subfornical organ to infralimbic cortex mechanism relays airway inflammation effects on fear extinction [PDF]

Journal of Neuroinflammation
There is growing interest in the impact of internal body states on the brain and behavior. The detrimental effects of chronic lung inflammation on mental health are well recognized; however, underlying mechanisms are not known. Here, using a murine model
Emily Allgire, Jaclyn W. McAlees, Rebecca A. Ahlbrand, Elizabeth Mancz, Lauren L. Vollmer, Andrew Winter, Katherine M.J. McMurray, Laura Maile, Bryan Sanders, William G. Ryan, Allan-Hermann Pool, Igal Ifergan, Eric S. Wohleb, Steve Davidson, Robert E. McCullumsmith, Ian P. Lewkowich, Renu Sah   +16 more
doaj   +2 more sources

Circulating mitochondria promoted endothelial cGAS-derived neuroinflammation in subfornical organ to aggravate sympathetic overdrive in heart failure mice [PDF]

Journal of Neuroinflammation
Background Sympathoexcitation contributes to myocardial remodeling in heart failure (HF). Increased circulating pro-inflammatory mediators directly act on the Subfornical organ (SFO), the cardiovascular autonomic center, to increase sympathetic outflow ...
Shutian Zhang, Dajun Zhao, Zhaohua Yang, Fanshun Wang, Shouguo Yang, Chunsheng Wang   +5 more
doaj   +2 more sources

Responses of perivascular macrophages to circulating lipopolysaccharides in the subfornical organ with special reference to endotoxin tolerance [PDF]

Journal of Neuroinflammation, 2019
Background Circulating endotoxins including lipopolysaccharides (LPS) cause brain responses such as fever and decrease of food and water intake, while pre-injection of endotoxins attenuates these responses.
Shoko Morita-Takemura, Kazuki Nakahara, Sanae Hasegawa-Ishii, Ayami Isonishi, Kouko Tatsumi, Hiroaki Okuda, Tatsuhide Tanaka, Masahiro Kitabatake, Toshihiro Ito, Akio Wanaka   +9 more
doaj   +2 more sources

Hydrogen sulfide regulates cardiovascular function by influencing the excitability of subfornical organ neurons. [PDF]

PLoS ONE, 2014
Hydrogen sulfide (H2S), a gasotransmitter endogenously found in the central nervous system, has recently been suggested to act as a signalling molecule in the brain having beneficial effects on cardiovascular function.
Markus Kuksis, Pauline M Smith, Alastair V Ferguson   +2 more
doaj   +2 more sources

Sex differences in responses to panicogen CO2 inhalation and the role of microglial acid-sensor TDAG8 in female mice [PDF]

Frontiers in Cellular Neuroscience
Prior work found microglial acid-sensor T-cell death-associated gene 8 (TDAG8) mediates panic-relevant responses to interoceptive stressor CO2 inhalation in male mice.
Shawn Lam, Pragnya Sai Priya Munisetti, Rebecca Ahlbrand, Rebecca Ahlbrand, Renu Sah, Renu Sah, Katherine M. J. McMurray   +6 more
doaj   +2 more sources

Plasticity of subfornical organ astrocyte structure and supraoptic nucleus hormone expression following extreme dehydration in the desert rodent Gerbillus tarabuli. [PDF]

J Neuroendocrinol
Abstract The central nervous system plays a pivotal role in the regulation of water and electrolyte balance, largely via the circumventricular organs (CVOs) and the hypothalamo‐neurohypophysial system. Gerbillus tarabuli, a desert‐dwelling rodent capable of surviving in arid environments, remains poorly characterized with respect to the neuroendocrine ...
Benhafri N, Remana S, Rouibate AD, Thirouin ZS, Dekar-Madoui A, Bourque CW, Ouali-Hassenaoui S.   +6 more
europepmc   +2 more sources

Morphofunctional Organization of the Subfornical Organ

Journal of Anatomy and Histopathology, 2023
This review contains literature data covering the structure and functions of the subfornical organ (SFO). The SFO belongs to the sensory group of formations located around the III and IV ventricles and constituting the circumventricular system of the brain.
D. A. Sokolov, N. T. Alexeeva, D. B. Nikityuk, S. V. Klochkova, E. L. Lushnikova   +4 more
openaire   +1 more source

Thirst recruits phasic dopamine signaling through subfornical organ neurons. [PDF]

Proc Natl Acad Sci U S A, 2020
Thirst is a highly potent drive that motivates organisms to seek out and consume balance-restoring stimuli. The detection of dehydration is well understood and involves signals of peripheral origin and the sampling of internal milieu by first order ...
Hsu TM, Bazzino P, Hurh SJ, Konanur VR, Roitman JD, Roitman MF.   +5 more
europepmc   +2 more sources

Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension

Brazilian Journal of Medical and Biological Research, 2011
Neurogenic hypertension has been the subject of extensive research worldwide. This review is based on the premise that some forms of neurogenic hypertension are caused in part by the formation of angiotensin-II (Ang-II)-induced reactive oxygen species ...
V.A. Braga, I.A. Medeiros, T.P. Ribeiro, M.S. França-Silva, M.S. Botelho-Ono, D.D. Guimarães   +5 more
doaj   +3 more sources