Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice [PDF]
eLife, 2019 The circumventricular organs (CVOs) in the central nervous system (CNS) lack a vascular blood-brain barrier (BBB), creating communication sites for sensory or secretory neurons, involved in body homeostasis.
Fabienne Benz +11 more
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Circulating mitochondria promoted endothelial cGAS-derived neuroinflammation in subfornical organ to aggravate sympathetic overdrive in heart failure mice [PDF]
Journal of NeuroinflammationBackground Sympathoexcitation contributes to myocardial remodeling in heart failure (HF). Increased circulating pro-inflammatory mediators directly act on the Subfornical organ (SFO), the cardiovascular autonomic center, to increase sympathetic outflow ...
Shutian Zhang +5 more
doaj +2 more sources
Responses of perivascular macrophages to circulating lipopolysaccharides in the subfornical organ with special reference to endotoxin tolerance [PDF]
Journal of Neuroinflammation, 2019 Background Circulating endotoxins including lipopolysaccharides (LPS) cause brain responses such as fever and decrease of food and water intake, while pre-injection of endotoxins attenuates these responses.
Shoko Morita-Takemura +9 more
doaj +2 more sources
Hydrogen sulfide regulates cardiovascular function by influencing the excitability of subfornical organ neurons. [PDF]
PLoS ONE, 2014 Hydrogen sulfide (H2S), a gasotransmitter endogenously found in the central nervous system, has recently been suggested to act as a signalling molecule in the brain having beneficial effects on cardiovascular function.
Markus Kuksis +2 more
doaj +2 more sources
Glial and perivascular structures in the subfornical organ: distinguishing the shell and core. [PDF]
J Histochem Cytochem, 2015 The subfornical organ (SFO) is a circumventricular organ with a chemosensitive function, and its vessels have no blood-brain barrier. Our study investigated the glial and vascular components in the SFO to determine whether their distributions indicate subdivisions, how to characterize the vessels and how to demarcate the SFO.
Pócsai K, Kálmán M.
europepmc +4 more sources
Thirst recruits phasic dopamine signaling through subfornical organ neurons. [PDF]
Proc Natl Acad Sci U S A, 2020 Thirst is a highly potent drive that motivates organisms to seek out and consume balance-restoring stimuli. The detection of dehydration is well understood and involves signals of peripheral origin and the sampling of internal milieu by first order ...
Hsu TM +5 more
europepmc +2 more sources
The regulation of subfornical organ neurons
, 2019 While the central nervous system (CNS) plays a critical role in the regulation of homeostasis, most of the CNS is isolated from constituents of the periphery by a blood-brain-barrier (BBB). The subfornical organ (SFO) is a specialised structure known as a sensory circumventricular organ (sensory CVO) which lacks a BBB, expresses a wide variety and ...
Peterson, Colleen
openaire +2 more sources
Morphofunctional Organization of the Subfornical Organ
Journal of Anatomy and Histopathology, 2023 This review contains literature data covering the structure and functions of the subfornical organ (SFO). The SFO belongs to the sensory group of formations located around the III and IV ventricles and constituting the circumventricular system of the brain.
D. A. Sokolov +4 more
openaire +1 more source
Increased (pro)renin receptor expression in the subfornical organ of hypertensive humans.
Am J Physiol Heart Circ Physiol, 2018 The central nervous system plays an important role in essential hypertension in humans and in animal models of hypertension through modulation of sympathetic activity and Na+and body fluid homeostasis. Data from animal models of hypertension suggest that
Cooper SG +8 more
europepmc +2 more sources
Brazilian Journal of Medical and Biological Research, 2011 Neurogenic hypertension has been the subject of extensive research worldwide. This review is based on the premise that some forms of neurogenic hypertension are caused in part by the formation of angiotensin-II (Ang-II)-induced reactive oxygen species ...
V.A. Braga +5 more
doaj +3 more sources