Results 31 to 40 of about 373 (115)

Image_1_Loss of Function of the Neural Cell Adhesion Molecule NrCAM Regulates Differentiation, Proliferation and Neurogenesis in Early Postnatal Hypothalamic Tanycytes.jpeg

, 2022
Hypothalamic tanycytes are neural stem and progenitor cells, but little is known of how they are regulated. Here we provide evidence that the cell adhesion molecule, NrCAM, regulates tanycytes in the adult niche.
Fran Ebling (12367651), Andrew Furley (8551281), Sarah Brown (2340313), Charlotte Muir (12367645), Seth Blackshaw (1586), Marysia Placzek (8551293), Iain Stewart (5279636), Marco Travaglio (12367648), Georgina K. C. Dowsett (12367642), Kavitha Chinnaiya (8551263), Dong Won Kim (2256052), Jo E. Lewis (3779404), Sarah Robins (12367639), Alex Moore (1554592)   +13 more
core   +1 more source

Regulating Integrin β1 to Restore Gonadotropin-Releasing Hormone–Tanycyte Unit Function in Polycystic Ovary Syndrome-Related Hypothalamic Dysregulation

Research
Excessive gonadotropin-releasing hormone (GnRH) is considered to be an initiating factor in the etiology of polycystic ovary syndrome (PCOS). GnRH neuronal axons terminate at the hypothalamic arcuate nucleus and median eminence, where tanycytes ...
Yu Wang, Xiaoyu Tong, Yan Xiao, Yicong Wang, Wei Hu, Wenhan Lu, Yuning Chen, Jiajia Li, Wenhao Gao, Hongru Gao, Yicheng Tian, Sizhe Dai, Yi Feng   +12 more
doaj   +1 more source

Protocol for simultaneous patch-clamp recording from tanycytes and neurons in living mouse brain slices

STAR Protocols, 2023
Summary: Here, we present a protocol for tanycyte-neuron paired whole-cell patch-clamp recording in living mouse brain slices. We describe steps for mice generation, solution preparation, and dissection.
Tori Lhomme, Vincent Prévot
doaj   +1 more source

The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders

Brain Pathology, EarlyView.
Aquaporin‐4 antibody‐positive neuromyelitis spectrum disorder is characterized by large tissue destructive lesions in medulla, spinal cord, and optic nerves, with only partial recovery from clinical symptoms, and by lesions with very little tissue destruction and mostly complete recovery from clinical symptoms, as seen in the area postrema ...
Qian Yu, Yoshiki Takai, Naoya Yamazaki, Sarah Brandl, Katharina M. Mair, Thibault Bouderlique, Maria Eleni Kastriti, Igor Adameyko, Romana Höftberger, Markus Reindl, Jan Bauer, Monika Bradl   +11 more
wiley   +1 more source

Image_4_Loss of Function of the Neural Cell Adhesion Molecule NrCAM Regulates Differentiation, Proliferation and Neurogenesis in Early Postnatal Hypothalamic Tanycytes.jpeg

, 2022
Hypothalamic tanycytes are neural stem and progenitor cells, but little is known of how they are regulated. Here we provide evidence that the cell adhesion molecule, NrCAM, regulates tanycytes in the adult niche.
Fran Ebling (12367651), Andrew Furley (8551281), Sarah Brown (2340313), Charlotte Muir (12367645), Seth Blackshaw (1586), Marysia Placzek (8551293), Iain Stewart (5279636), Marco Travaglio (12367648), Georgina K. C. Dowsett (12367642), Kavitha Chinnaiya (8551263), Dong Won Kim (2256052), Jo E. Lewis (3779404), Sarah Robins (12367639), Alex Moore (1554592)   +13 more
core   +1 more source

Seasonal changes in activity of hypothalamic thyroid hormone system in different winter phenotypes of Djungarian hamster (Phodopus sungorus).

PLoS ONE
Although the Djungarian hamster (Phodopus sungorus) is a seasonality model, it presents substantial variability in winter acclimation. In response to short photoperiod, some individuals express a suite of winter traits such as low body mass, regressed ...
Anna S Przybylska-Piech, Victoria Diedrich, Annika Herwig   +2 more
doaj   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Image_7_Loss of Function of the Neural Cell Adhesion Molecule NrCAM Regulates Differentiation, Proliferation and Neurogenesis in Early Postnatal Hypothalamic Tanycytes.jpeg

, 2022
Hypothalamic tanycytes are neural stem and progenitor cells, but little is known of how they are regulated. Here we provide evidence that the cell adhesion molecule, NrCAM, regulates tanycytes in the adult niche.
Fran Ebling (12367651), Andrew Furley (8551281), Sarah Brown (2340313), Charlotte Muir (12367645), Seth Blackshaw (1586), Marysia Placzek (8551293), Iain Stewart (5279636), Marco Travaglio (12367648), Georgina K. C. Dowsett (12367642), Kavitha Chinnaiya (8551263), Dong Won Kim (2256052), Jo E. Lewis (3779404), Sarah Robins (12367639), Alex Moore (1554592)   +13 more
core   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Image_2_Loss of Function of the Neural Cell Adhesion Molecule NrCAM Regulates Differentiation, Proliferation and Neurogenesis in Early Postnatal Hypothalamic Tanycytes.jpeg

, 2022
Hypothalamic tanycytes are neural stem and progenitor cells, but little is known of how they are regulated. Here we provide evidence that the cell adhesion molecule, NrCAM, regulates tanycytes in the adult niche.
Fran Ebling (12367651), Andrew Furley (8551281), Sarah Brown (2340313), Charlotte Muir (12367645), Seth Blackshaw (1586), Marysia Placzek (8551293), Iain Stewart (5279636), Marco Travaglio (12367648), Georgina K. C. Dowsett (12367642), Kavitha Chinnaiya (8551263), Dong Won Kim (2256052), Jo E. Lewis (3779404), Sarah Robins (12367639), Alex Moore (1554592)   +13 more
core   +1 more source