Results 11 to 20 of about 13,855 (152)
Rare cause of ketolysis: Monocarboxylate transporter 1 deficiency
The Turkish Journal of Pediatrics, 2022 Background. Monocarboxylate transporter 1 (MCT1) deficiency (MIM #616095) is a relatively new identified cause of recurrent ketoacidosis triggered by fasting or infections. MCT1 was first described in 2014 by van Hasselt et al. to result from both
Ayşe Ergül Bozacı +1 more
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Monocarboxylate transporter and lactate metabolism
Journal of Physical Fitness and Sports Medicine, 2012 For many years, lactate was considered as a metabolic waste product, and a cause of fatigue during exercise. However, lactate is now known as a carbohydrate fuel source, shuttled between cells and tissues.
Yu Kitaoka, Daisuke Hoshino, Hideo Hatta
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Monocarboxylate Transporter 8 Deficiency: Delayed or Permanent Hypomyelination?
Frontiers in Endocrinology, 2020 Monocarboxylate transporter 8 (MCT8) deficiency or the Allan-Herndon-Dudley Syndrome (AHDS) is an X-linked psychomotor disability syndrome with around 320 clinical cases described worldwide.
Pieter Vancamp +2 more
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Uptake and Advanced Therapy of Butyrate in Inflammatory Bowel Disease
Immuno, 2022 The pathogenesis and refractory nature of inflammatory bowel disease (IBD) are related to multiple factors, including genetic factors, environmental factors, and abnormalities in gut microbial diversity, which lead to decreased levels of short-chain ...
Shinji Ota, Hirotake Sakuraba
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Journal of Biomedical Science, 2022 Background Amyotrophic lateral sclerosis (ALS) is a devasting neurodegenerative disorder for which no successful therapeutics are available. Valproic acid (VPA), a monocarboxylate derivative, is a known antiepileptic drug and a histone deacetylase ...
Asmita Gyawali +5 more
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The Iraqi Journal of Medical Sciences, 2019 Background: Circumventricular organs (CVOs) are specialized structures border the brain ventricles and lack the blood-brain barrier. These CVOs are lined by specialized ependymal cells (ECs) called tanycyte.
Haider F. Jawad +2 more
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Nature Communications, 2017 Invasion of the adipose tissue correlates with poor prognosis in breast cancer. Here, the authors show that mammary gland adipocytes promote malignancy via β-hydroxybutyrate, which acts on cancer cells through the monocarboxylate transporter MCT2 ...
Chun-Kai Huang +8 more
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Intestinal OCTN2- and MCT1-targeted drug delivery to improve oral bioavailability
Asian Journal of Pharmaceutical Sciences, 2020 Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs, thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.
Gang Wang +8 more
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Exercise-induced hyperinsulinism: genetic basis and clinical management
中国当代儿科杂志Exercise-induced hyperinsulinism, also known as monocarboxylate transporter 1 hyperinsulinemia, is a rare subtype of congenital hyperinsulinism caused by gain-of-function variants in the SLC16A1 gene, which encodes monocarboxylate transporter 1.
ZHANG Qi-Ting, HOU Ling
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Generation of iPSC lines with SLC16A2:G401R or SLC16A2 knock out
Stem Cell Research, 2023 The X-linked Allan-Herndon-Dudley syndrome (AHDS) is characterized by severely impaired psychomotor development and is caused by mutations in the SLC16A2 gene encoding the thyroid hormone transporter MCT8 (monocarboxylate transporter 8).
Katarzyna Anna Ludwik +7 more
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