Results 11 to 20 of about 13,009 (197)

Monocarboxylate transporter and lactate metabolism

Journal of Physical Fitness and Sports Medicine, 2012
For many years, lactate was considered as a metabolic waste product, and a cause of fatigue during exercise. However, lactate is now known as a carbohydrate fuel source, shuttled between cells and tissues.
Yu Kitaoka, Daisuke Hoshino, Hideo Hatta
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Cooperative transport mechanism of human monocarboxylate transporter 2 [PDF]

Nature Communications, 2020
Proton-linked monocarboxylate transporters (MCTs) facilitate monocarboxylate efflux in glycolytically active cells and regulate transport down in glycolytically inactive cells.
Bo Zhang, Qiuheng Jin, Lizhen Xu, Ningning Li, Ying Meng, Shenghai Chang, Xiang Zheng, Jiangqin Wang, Yuan Chen, Dante Neculai, Ning Gao, Xiaokang Zhang, Fan Yang, Jiangtao Guo, Sheng Ye   +14 more
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Monocarboxylate Transporter 8 Deficiency: From Pathophysiological Understanding to Therapy Development

Frontiers in Endocrinology, 2021
Genetic defects in the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) result in MCT8 deficiency. This disorder is characterized by a combination of severe intellectual and motor disability, caused by decreased cerebral thyroid hormone ...
Ferdy S. van Geest, Nilhan Gunhanlar, Stefan Groeneweg, W. Edward Visser   +3 more
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Monocarboxylate transporters in the brain and in cancer [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016
Monocarboxylate transporters (MCTs) constitute a family of 14 members among which MCT1-4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and ketone bodies together with protons across cell membranes. Their anchorage and activity at the plasma membrane requires interaction with chaperon protein such as basigin/CD147 and ...
Pérez-Escuredo J, Van Hée VF, Sboarina M, Falces J, Payen VL, Pellerin L, Sonveaux P   +6 more
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Monocarboxylate transporters in cancer

Molecular Metabolism, 2020
Tumors are highly plastic metabolic entities composed of cancer and host cells that can adopt different metabolic phenotypes. For energy production, cancer cells may use 4 main fuels that are shuttled in 5 different metabolic pathways. Glucose fuels glycolysis that can be coupled to the tricarboxylic acid (TCA) cycle and oxidative phosphorylation ...
Valéry L. Payen, Erica Mina, Vincent F. Van Hée, Paolo E. Porporato, Pierre Sonveaux   +4 more
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Rare cause of ketolysis: Monocarboxylate transporter 1 deficiency

The Turkish Journal of Pediatrics, 2022
Background. Monocarboxylate transporter 1 (MCT1) deficiency (MIM #616095) is a relatively new identified cause of recurrent ketoacidosis triggered by fasting or infections. MCT1 was first described in 2014 by van Hasselt et al. to result from both
Ayşe Ergül Bozacı, Aysel Tekmenuray Ünal   +1 more
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Monocarboxylate transporter expression in mouse brain [PDF]

American Journal of Physiology-Endocrinology and Metabolism, 1998
Although glucose is the major metabolic fuel needed for normal brain function, monocarboxylic acids, i.e., lactate, pyruvate, and ketone bodies, can also be utilized by the brain as alternative energy substrates. In most mammalian cells, these substrates are transported either into or out of the cell by a family of monocarboxylate transporters (MCTs),
E M, Koehler-Stec, I A, Simpson, S J, Vannucci, K T, Landschulz, W H, Landschulz   +4 more
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Monocarboxylate Transporter 1 Deficiency and Ketone Utilization [PDF]

New England Journal of Medicine, 2014
Ketoacidosis is a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. We performed exome sequencing in a patient with recurrent, severe ketoacidosis and identified a homozygous frameshift mutation in the gene encoding monocarboxylate transporter 1 (SLC16A1, also called MCT1 ...
Hasselt, P.M. van, Ferdinandusse, S., Monroe, G.R., Ruiter, J.P., Turkenburg, M., Geerlings, M.J., Duran, K., Harakalova, M., Zwaag, B. van der, Monavari, A.A., Okur, I., Sharrard, M.J., Cleary, M., O'Connell, N., Walker, V., Rubio-Gozalbo, M.E., Vries, M.C. de, Visser, G., Houwen, R.H.J., Smagt, J.J. van der, Verhoeven-Duif, N.M., Wanders, R.J., Haaften, G. van   +22 more
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Monocarboxylate Transporter 8 Deficiency: Delayed or Permanent Hypomyelination?

Frontiers in Endocrinology, 2020
Monocarboxylate transporter 8 (MCT8) deficiency or the Allan-Herndon-Dudley Syndrome (AHDS) is an X-linked psychomotor disability syndrome with around 320 clinical cases described worldwide.
Pieter Vancamp, Barbara A. Demeneix, Sylvie Remaud   +2 more
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Uptake and Advanced Therapy of Butyrate in Inflammatory Bowel Disease

Immuno, 2022
The pathogenesis and refractory nature of inflammatory bowel disease (IBD) are related to multiple factors, including genetic factors, environmental factors, and abnormalities in gut microbial diversity, which lead to decreased levels of short-chain ...
Shinji Ota, Hirotake Sakuraba
doaj   +1 more source