Results 1 to 10 of about 12,791 (189)

Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review [PDF]

International Journal of Molecular Sciences, 2023
Energy production by cancer is driven by accelerated glycolysis, independently of oxygen levels, which results in increased lactate production. Lactate is shuttled to and from cancer cells via monocarboxylate transporters (MCTs). MCT1 works both as an importer and an extruder of lactate, being widely studied in recent years and generally associated ...
Filipa Pinto-Ribeiro, Baltazar F, Marta Costa   +2 more
exaly   +4 more sources

H3K9ac and HDAC2 Activity Are Involved in the Expression of Monocarboxylate Transporter 1 in Oligodendrocyte [PDF]

Frontiers in Molecular Neuroscience, 2017
Recently, it is reported that monocarboxylate transporter 1 (MCT1) plays crucial role in oligodendrocyte differentiation and myelination. We found that MCT1 is strongly expressed in oligodendrocyte but weakly expressed in oligodendrocyte precursors (OPCs)
Qingwei Lai, Qingwei Lai, Wantong Du, Jian Wu, Xiao Wang, Xiao Wang, Xinyu Li, Xuebin Qu, Xiuxiang Wu, Fuxing Dong, Ruiqin Yao, Hongbin Fan, Hongbin Fan   +12 more
doaj   +5 more sources

Rare cause of ketolysis: Monocarboxylate transporter 1 deficiency

The Turkish Journal of Pediatrics, 2022
Background. Monocarboxylate transporter 1 (MCT1) deficiency (MIM #616095) is a relatively new identified cause of recurrent ketoacidosis triggered by fasting or infections. MCT1 was first described in 2014 by van Hasselt et al. to result from both
Ayşe Ergül Bozacı, Aysel Tekmenuray Ünal   +1 more
doaj   +3 more sources

Monocarboxylate Transporter 1 (MCT1) Mediates Succinate Export in the Retina. [PDF]

Invest Ophthalmol Vis Sci, 2022
Succinate is exported by the retina and imported by eyecup tissue. The transporters mediating this process have not yet been identified. Recent studies showed that monocarboxylate transporter 1 (MCT1) can transport succinate across plasma membranes in cardiac and skeletal muscle.
Bisbach CM, Hass DT, Thomas ED, Cherry TJ, Hurley JB.   +4 more
europepmc   +3 more sources

Monocarboxylate Transporter 1 (MCT1) in Liver Pathology. [PDF]

Int J Mol Sci, 2020
Membrane monocarboxylate transporter 1 (SLC16A1/MCT1) plays an important role in hepatocyte homeostasis, as well as drug handling. However, there is no available information about the impact of liver pathology on the transporter levels and function. The study was aimed to quantify SLC16A1 mRNA (qRT-PCR) and MCT1 protein abundance (liquid chromatography–
Droździk M, Szeląg-Pieniek S, Grzegółkowska J, Łapczuk-Romańska J, Post M, Domagała P, Miętkiewski J, Oswald S, Kurzawski M.   +8 more
europepmc   +4 more sources

Immunoreactivity and a new staining method of monocarboxylate transporter 1 located in endothelial cells of cerebral vessels of human brain in distinguishing cerebral venules from arterioles [PDF]

European Journal of Histochemistry, 2021
Distinguishing brain venules from arterioles with arteriolosclerosis is less reliable using traditional staining methods. We aimed to immunohistochemically assess the monocarboxylate transporter 1 (MCT1), a specific marker of venous endothelium found in ...
Yuan Cao, Dong-Hui Ao, Chao Ma, Wen-Ying Qiu, Yi-Cheng Zhu   +4 more
doaj   +2 more sources

Monocarboxylate Transporter-1 Is Dispensable for Hepatocellular Carcinoma Development. [PDF]

Mol Carcinog
ABSTRACTHepatocellular carcinoma (HCC) is the most prevalent type of liver cancer and the deadliest liver disease. It is imperative to understand the underlying molecular mechanisms involved in the development of HCC. Monocarboxylate transporter‐1 (MCT1) is a proton‐coupled protein that facilitates the bidirectional transport of monocarboxylates, such ...
Gad SA, Bridgeman B, Boedeker K, Ding X, Qiu W.   +4 more
europepmc   +3 more sources

Deciphering metabolic heterogeneity in retinoblastoma unravels the role of monocarboxylate transporter 1 in tumor progression [PDF]

Biomarker Research
Background Tumors exhibit metabolic heterogeneity, influencing cancer progression. However, understanding metabolic diversity in retinoblastoma (RB), the primary intraocular malignancy in children, remains limited.
Junjie Tang, Yaoming Liu, Yinghao Wang, Zhihui Zhang, Jiahe Nie, Xinyue Wang, Siming Ai, Jinmiao Li, Yang Gao, Cheng Li, Chao Cheng, Shicai Su, Shuxia Chen, Ping Zhang, Rong Lu   +14 more
doaj   +2 more sources

Tracing Nutrient Flux Following Monocarboxylate Transporter-1 Inhibition with AZD3965. [PDF]

Cancers (Basel), 2020
The monocarboxylate transporter 1 (MCT1) is a key element in tumor cell metabolism and inhibition of MCT1 with AZD3965 is undergoing clinical trials. We aimed to investigate nutrient fluxes associated with MCT1 inhibition by AZD3965 to identify possible biomarkers of drug action.
Braga M, Kaliszczak M, Carroll L, Schug ZT, Heinzmann K, Baxan N, Benito A, Valbuena GN, Stribbling S, Beckley A, Mackay G, Mauri F, Latigo J, Barnes C, Keun H, Gottlieb E, Aboagye EO.   +16 more
europepmc   +6 more sources

Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus [PDF]

Neurobiology of Disease, 2011
Monocarboxylate transporter 1 (MCT1) facilitates the transport of important metabolic fuels (lactate, pyruvate and ketone bodies) and possibly also acidic drugs such as valproic acid across the blood–brain barrier.
Fredrik Lauritzen, Nihal C. de Lanerolle, Tih-Shih W. Lee, Dennis D. Spencer, Jung H. Kim, Linda H. Bergersen, Tore Eid   +6 more
doaj   +3 more sources