Results 11 to 20 of about 12,791 (189)

Monocarboxylate Transporter 1 Inhibitors as Potential Anticancer Agents [PDF]

ACS Medicinal Chemistry Letters, 2015
Potent monocarboxylate transporter 1 inhibitors (MCT1) have been developed based on α-cyano-4-hydroxycinnamic acid template. Structure-activity relationship studies demonstrate that the introduction of p-N, N-dialkyl/diaryl, and o-methoxy groups into cyanocinnamic acid has maximal MCT1 inhibitory activity.
Sravan Jonnalagadda, Lester Drewes, Venkatram Mereddy   +2 more
exaly   +3 more sources

Developmental Expression of Monocarboxylate Transporter 1 and 4 in Rat Liver

Journal of Pharmacy & Pharmaceutical Sciences, 2019
Purpose: Monocarboxylate transporters (MCT) are proton-coupled integral membrane proteins that control the influx and efflux of endogenous monocarboxylates such as lactate, acetate and pyruvate. They also transport and mediate the clearance of drugs such
Michael Ng, Justin Louie, Jieyun Cao, Melanie A Felmlee   +3 more
doaj   +4 more sources

Monocarboxylate transporter-1 (MCT1) protein expression in head and neck cancer affects clinical outcome [PDF]

Scientific Reports, 2021
Treatment of locally advanced, unresectable head and neck squamous cell carcinoma (HNSCC) often yields only modest results with radiochemotherapy (RCT) as standard of care.
Martin Leu, J. Kitz, Y. Pilavakis, S. Hakroush, H. A. Wolff, M. Canis, S. Rieken, M. A. Schirmer   +7 more
doaj   +2 more sources

Cyclosporine protects from intestinal epithelial injury by modulating butyrate uptake via upregulation of membrane monocarboxylate transporter 1 levels [PDF]

Biochemistry and Biophysics Reports, 2020
Background and aims: A relationship between treatment outcomes and intestinal microbiota in patients with inflammatory bowel diseases has been demonstrated. Cyclosporine treatment leads to rapid improvement in severe ulcerative colitis.
Shinji Ota, Hirotake Sakuraba, Hiroto Hiraga, Shukuko Yoshida, Miwa Satake, Yui Akemoto, Nahoko Tanaka, Rina Watanabe, Maeda Takato, Yasuhisa Murai, Kayo Ueno, Takenori Niioka, Makoto Hayakari, Yoh Ishiguro, Shinsaku Fukuda   +14 more
doaj   +2 more sources

Role of Human Monocarboxylate Transporter 1 (hMCT1) and 4 (hMCT4) in Tumor Cells and the Tumor Microenvironment [PDF]

Cancer Management and Research, 2023
Shangcong Han, Guiming Zhang, Tian Liu   +2 more
exaly   +2 more sources

Inhibition Of Monocarboxylate Transporter 1 In Spinal Cord Horn Significantly Reverses Chronic Inflammatory Pain [PDF]

Journal of Pain Research, 2019
Jian-hua He,1,* Ling Yu,2,* Zhi-yong Wang,1 Qiang Wang,3 Jun-Li Cao,4 Lian-bing Gu1 1Department of Anesthesiology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing ...
He J, Yu L, Wang Z, Wang Q, Cao JL, Gu L
doaj   +2 more sources

Monocarboxylate transporter 1 and the vulnerability of oligodendrocyte lineage cells to metabolic stresses. [PDF]

CNS Neurosci Ther, 2018
SummaryAimsOligodendrocytes, especially oligodendrocyte precursor cells, are known to be sensitive to hypoxic and metabolic stresses. Vulnerability of oligodendrocytes is considered a contributing factor to white matter dysfunction. However, little is known about the energy processing characteristics of oligodendrocyte lineage cells under basal and ...
Zhou P, Guan T, Jiang Z, Namaka M, Huang QJ, Kong JM.   +5 more
europepmc   +4 more sources

Monocarboxylate Transporter 1 Deficiency and Ketone Utilization [PDF]

New England Journal of Medicine, 2014
Ketoacidosis is a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. We performed exome sequencing in a patient with recurrent, severe ketoacidosis and identified a homozygous frameshift mutation in the gene encoding monocarboxylate transporter 1 (SLC16A1, also called MCT1 ...
Hasselt, P.M. van, Ferdinandusse, S., Monroe, G.R., Ruiter, J.P., Turkenburg, M., Geerlings, M.J., Duran, K., Harakalova, M., Zwaag, B. van der, Monavari, A.A., Okur, I., Sharrard, M.J., Cleary, M., O'Connell, N., Walker, V., Rubio-Gozalbo, M.E., Vries, M.C. de, Visser, G., Houwen, R.H.J., Smagt, J.J. van der, Verhoeven-Duif, N.M., Wanders, R.J., Haaften, G. van   +22 more
openaire   +11 more sources

Monocarboxylate Transporters 1 and 4 and MTCO1 in Gastric Cancer [PDF]

Cancers, 2021
Background: Monocarboxylate transporters (MCTs) appear to play an important role in tumor development and aggressiveness. The present study aimed to evaluate associations between cytoplasmic MCT1, MCT4, and mitochondrial cytochrome c oxidase (MTCO1) expression and clinicopathological variables or survival in gastric cancer.
Kauppila Joonas, Eskuri Maarit Janita, Kemi Niko Aleksi   +2 more
openaire   +3 more sources

Hypoxia-inducible factor 1a (HIF 1a) and monocarboxylate transporter 1 (MCT 1) in papillary thyroid carcinoma; A study in Sulaimani City/Iraq

Advanced Medical Journal, 2023
Background and objectives: Papillary thyroid carcinoma is one of the most common cancers of human, monocarbox- ylate transporter 1 and hypoxia inducible factor 1 alpha expressions in many tumors have recently being targets for treatment, HIF-1a has been
Hadeel Adnan Yasseen, Ari Mohammed Abdullah   +1 more
doaj   +1 more source