Results 11 to 20 of about 113,465,300 (217)

Monocarboxylate Transporter 1 Deficiency and Ketone Utilization [PDF]

New England Journal of Medicine, 2014
Ketoacidosis is a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. We performed exome sequencing in a patient with recurrent, severe ketoacidosis and identified a homozygous frameshift mutation in the gene encoding monocarboxylate transporter 1 (SLC16A1, also called MCT1 ...
Hasselt, P.M. van, Ferdinandusse, S., Monroe, G.R., Ruiter, J.P., Turkenburg, M., Geerlings, M.J., Duran, K., Harakalova, M., Zwaag, B. van der, Monavari, A.A., Okur, I., Sharrard, M.J., Cleary, M., O'Connell, N., Walker, V., Rubio-Gozalbo, M.E., Vries, M.C. de, Visser, G., Houwen, R.H.J., Smagt, J.J. van der, Verhoeven-Duif, N.M., Wanders, R.J., Haaften, G. van   +22 more
core   +14 more sources

Monocarboxylate Transporter 1 (MCT1) in Liver Pathology. [PDF]

Int J Mol Sci, 2020
Membrane monocarboxylate transporter 1 (SLC16A1/MCT1) plays an important role in hepatocyte homeostasis, as well as drug handling. However, there is no available information about the impact of liver pathology on the transporter levels and function. The study was aimed to quantify SLC16A1 mRNA (qRT-PCR) and MCT1 protein abundance (liquid chromatography–
Droździk M, Szeląg-Pieniek S, Grzegółkowska J, Łapczuk-Romańska J, Post M, Domagała P, Miętkiewski J, Oswald S, Kurzawski M.   +8 more
europepmc   +6 more sources

Monocarboxylate Transporter 1 Inhibitors as Potential Anticancer Agents [PDF]

ACS Medicinal Chemistry Letters, 2015
Potent monocarboxylate transporter 1 inhibitors (MCT1) have been developed based on α-cyano-4-hydroxycinnamic acid template. Structure-activity relationship studies demonstrate that the introduction of p-N, N-dialkyl/diaryl, and o-methoxy groups into cyanocinnamic acid has maximal MCT1 inhibitory activity.
Shirisha, Gurrapu, Sravan K, Jonnalagadda, Mohammad A, Alam, Grady L, Nelson, Mary G, Sneve, Lester R, Drewes, Venkatram R, Mereddy   +6 more
openaire   +3 more sources

Developmental Expression of Monocarboxylate Transporter 1 and 4 in Rat Liver

Journal of Pharmacy & Pharmaceutical Sciences, 2019
Purpose: Monocarboxylate transporters (MCT) are proton-coupled integral membrane proteins that control the influx and efflux of endogenous monocarboxylates such as lactate, acetate and pyruvate. They also transport and mediate the clearance of drugs such
Michael Ng, Justin Louie, Jieyun Cao, Melanie A Felmlee   +3 more
doaj   +4 more sources

Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus [PDF]

Neurobiology of Disease, 2011
Monocarboxylate transporter 1 (MCT1) facilitates the transport of important metabolic fuels (lactate, pyruvate and ketone bodies) and possibly also acidic drugs such as valproic acid across the blood–brain barrier.
Fredrik Lauritzen, Nihal C. de Lanerolle, Tih-Shih W. Lee, Dennis D. Spencer, Jung H. Kim, Linda H. Bergersen, Tore Eid   +6 more
doaj   +3 more sources

H3K9ac and HDAC2 Activity Are Involved in the Expression of Monocarboxylate Transporter 1 in Oligodendrocyte [PDF]

Frontiers in Molecular Neuroscience, 2017
Recently, it is reported that monocarboxylate transporter 1 (MCT1) plays crucial role in oligodendrocyte differentiation and myelination. We found that MCT1 is strongly expressed in oligodendrocyte but weakly expressed in oligodendrocyte precursors (OPCs)
Qingwei Lai, Qingwei Lai, Wantong Du, Jian Wu, Xiao Wang, Xiao Wang, Xinyu Li, Xuebin Qu, Xiuxiang Wu, Fuxing Dong, Ruiqin Yao, Hongbin Fan, Hongbin Fan   +12 more
doaj   +3 more sources

Inhibition of Monocarboxylate Transporter-1 (MCT1) by AZD3965 Enhances Radiosensitivity by Reducing Lactate Transport [PDF]

Molecular Cancer Therapeutics, 2014
Abstract Inhibition of the monocarboxylate transporter MCT1 by AZD3965 results in an increase in glycolysis in human tumor cell lines and xenografts. This is indicated by changes in the levels of specific glycolytic metabolites and in changes in glycolytic enzyme kinetics.
Bola, Becky M, Chadwick, Amy, Michopoulos, Filippos, Blount, Kathryn G, Telfer, Brian A, Williams, Kaye, Smith, Paul D, Critchlow, Susan E, Stratford, Ian J   +8 more
openaire   +3 more sources

Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes. Expression of two different monocarboxylate transporters in astroglial cells and neurons.

The Journal of biological chemistry, 1997
The transport of lactate is an essential part of the concept of metabolic coupling between neurons and glia. Lactate transport in primary cultures of astroglial cells was shown to be mediated by a single saturable transport system with a Km value for lactate of 7.7 mM and a Vmax value of 250 nmol/(min x mg of protein).
Bröer, S, Rahman, B, Pellegri, G, Pellerin, L, Martin, J L, Verleysdonk, S, Hamprecht, B, Magistretti, P J   +7 more
core   +5 more sources

Monocarboxylate Transporter 1 (MCT1) Mediates Succinate Export in the Retina. [PDF]

Invest Ophthalmol Vis Sci, 2022
Succinate is exported by the retina and imported by eyecup tissue. The transporters mediating this process have not yet been identified. Recent studies showed that monocarboxylate transporter 1 (MCT1) can transport succinate across plasma membranes in cardiac and skeletal muscle.
Bisbach CM, Hass DT, Thomas ED, Cherry TJ, Hurley JB.   +4 more
europepmc   +3 more sources

Transport mechanism and drug discovery of human monocarboxylate transporter 1. [PDF]

Acta Pharmacol Sin
Human monocarboxylate transporters (MCTs) are crucial for tumour cell glycolysis. Inhibiting MCT-mediated lactate transport can suppress the proliferation of solid tumours and enhance the efficacy of the immune system against tumours. Despite the importance of this transporter, the molecular mechanism of lactate transport by MCT1 remains elusive ...
Shi S, Li JC, Zhou XY, Li ZL, Wang YX, Xu BH, Ye S.   +6 more
europepmc   +3 more sources