Results 1 to 10 of about 10,143 (187)

SETDB1 Methylates MCT1 Promoting Tumor Progression by Enhancing the Lactate Shuttle

Advanced Science, 2023
MCT1 is a critical protein found in monocarboxylate transporters that plays a significant role in regulating the lactate shuttle. However, the post‐transcriptional modifications that regulate MCT1 are not clearly identified. In this study, it is reported
Guihua Wang, Li Sun
exaly   +2 more sources

Study on the expression of lactate transport-related proteins in follicular lymphoma and their relationship with clinicopathologic features [PDF]

Frontiers in Cell and Developmental Biology
ObjectiveTo investigate the expression of the lactate transport-related proteins MCT1, MCT4, and their chaperone CD147 in follicular lymphoma (FL), and to delineate their potential correlations with clinicopathological parameters predictive of prognosis ...
Zheng Xu, Xuemei Wang, Jiuling Li, Xin Zhang, Xueju Wang   +4 more
doaj   +2 more sources

Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar [PDF]

Nature Communications
Hypertrophic scar (HS) is a fibroproliferative disorder characterized by fibroblast hyperactivation and aberrant extracellular matrix deposition. This study identifies macrophage-derived lactate as a key mediator of fibroblast phenotypic remodeling via ...
Yixuan Yuan, Yujie Xiao, Jie Zou, Liang Luo, Mengyang Li, Kuo Shen, Lai Wei, Yihao Zhang, Peng Wang, Yan Chen, Shixuan Zhuo, Hao Zhang, Shijie Song, Yanhui Jia, Kejia Wang, Shiqing Jiang, Hao Guan, Dahai Hu   +17 more
doaj   +2 more sources

Metabolic marker profiling of circulating tumour cells in NSCLC patients treated with osimertinib: focus on MCT1 and MCT4 [PDF]

Therapeutic Advances in Medical Oncology
Background: Monocarboxylate transporters (MCTs) facilitate lactate transfer and support cancer cell survival and metastasis. MCT1 and MCT4 expression has been associated with poor prognosis and resistance to therapy with tyrosine kinase inhibitors ...
Karolina Mangani, Evangelia Pantazaka, Evi Lianidou, Vassilis Georgoulias, Athanasios Kotsakis, Athina Markou, Galatea Kallergi   +6 more
doaj   +2 more sources

Focused Ultrasound-Induced Mechanical Ablation Affects the Carbohydrate Metabolism of Residual/Peri-Focally Localized Glioblastoma Cells. [PDF]

Int J Cancer
Glioblastoma (GBM) is highly aggressive and therapy‐resistant, warranting exploration of novel treatment strategies, among them mechanical high‐intensity focused ultrasound (mFUS), which holds significant promise for tumor ablation. The present study examined mFUS‐induced changes specifically in carbohydrate metabolism, which affects vulnerability to ...
Bayler F, Holler J, Clüver J, Johanning L, Hellmold D, Schröder NO, Nojszewski J, Ahmeti H, Kubelt-Kwamin C, Synowitz M, Held-Feindt J.   +10 more
europepmc   +2 more sources

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

Cell Reports, 2018
Summary: Highly glycolytic cancer cells prevent intracellular acidification by excreting the glycolytic end-products lactate and H+ via the monocarboxylate transporters 1 (MCT1) and 4 (MCT4).
Michael N Hall, Christoph Moroni, Heidi Lane   +2 more
exaly   +3 more sources

MCT1 as a critical regulator of insulin signaling, energy homeostasis and podocyte function [PDF]

Scientific Reports
Podocytes are highly specialized epithelial cells that play a central role in maintaining integrity of the glomerular filtration barrier. Because of their complex architecture and dynamic actin-based cytoskeleton, podocytes have substantial energy ...
Maria Szrejder, Irena Audzeyenka, Patrycja Rachubik, Dorota Rogacka, Agnieszka Piwkowska   +4 more
doaj   +2 more sources

Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity [PDF]

Nature Communications
Itaconate accumulates in macrophages upon bacterial infection, and manifests antibacterial activity. Convincing evidence substantiates that itaconate is transported across the plasma membrane and vacuolar membrane, but the molecular bases underlying ...
Qingcai Meng, Chengxi Li, Yuping Cai, Ying Chen, Xiaoqing Chen, Xin Wang, Biling Zhang, Yue Zhang, Feng Liu, Meixin Chen   +9 more
doaj   +2 more sources

MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration

Cell Reports, 2021
Summary: Oligodendrocytes (OLs) are important for myelination and shuttling energy metabolites lactate and pyruvate toward axons through their expression of monocarboxylate transporter 1 (MCT1).
Thomas Philips, Yevgeniya A. Mironova, Yan Jouroukhin, Jeannie Chew, Svetlana Vidensky, Mohamed H. Farah, Mikhail V. Pletnikov, Dwight E. Bergles, Brett M. Morrison, Jeffrey D. Rothstein   +9 more
doaj   +1 more source

Monocarboxylate Transporter 1 May Benefit Cerebral Ischemia via Facilitating Lactate Transport From Glial Cells to Neurons

Frontiers in Neurology, 2022
Monocarboxylate transporter 1 (MCT1) is expressed in glial cells and some populations of neurons. MCT1 facilitates astrocytes or oligodendrocytes (OLs) in the energy supplement of neurons, which is crucial for maintaining the neuronal activity and axonal
Mao Zhang, Yanyan Wang, Yun Bai, Limeng Dai, Hong Guo   +4 more
doaj   +1 more source