Results 11 to 20 of about 13,060 (191)

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis [PDF]

eLife
Circulating lactate is a fuel source for liver metabolism but may exacerbate metabolic diseases such as nonalcoholic steatohepatitis (NASH). Indeed, haploinsufficiency of lactate transporter monocarboxylate transporter 1 (MCT1) in mice reportedly ...
Kyounghee Min, Batuhan Yenilmez, Mark Kelly, Dimas Echeverria, Michael Elleby, Lawrence M Lifshitz, Naideline Raymond, Emmanouela Tsagkaraki, Shauna M Harney, Chloe DiMarzio, Hui Wang, Nicholas McHugh, Brianna Bramato, Brett Morrison, Jeffery D Rothstein, Anastasia Khvorova, Michael P Czech   +16 more
doaj   +2 more sources

The characteristics of perivascular proinflammation in 4-repeat tauopathies. [PDF]

Brain Pathol
The spatial distribution of perivascular proinflammation differs between PSP and CBD: PSP shows a predominance in basal ganglia (BG), whereas CBD demonstrates more widespread involvement of both BG and superior/middle frontal gyrus (S/M‐FG). PSP exhibits profound proinflammatory activation around venules while CBD affects a comparable magnitude around ...
Fu MH, Uruk G, Gatto RG, Reichard RR, Whitwell JL, Josephs KA.   +5 more
europepmc   +2 more sources

Lactate Homeostasis Disruption Potentiates TACE-Immunotherapy in Hepatocellular Carcinoma. [PDF]

Adv Sci (Weinh)
Lactate homeostasis is disrupted through spatially coordinated extracellular neutralization and intracellular acidification, triggering calcium overload, mitochondrial dysfunction, and immunogenic cell death. This metabolic reprogramming alleviates the immunosuppressive tumor microenvironment and enhances immune checkpoint blockade, providing a ...
Chen M, Chen X, Yang B, Xu H, Sun X, Qi H, Hu H, Wu R, Qiu F, Wu B, Luo Y, Shu G, Ji J.   +12 more
europepmc   +2 more sources

Monocarboxylate Transporter 1 (MCT1) in Liver Pathology [PDF]

, 2020
Membrane monocarboxylate transporter 1 (SLC16A1/MCT1) plays an important role in hepatocyte homeostasis, as well as drug handling. However, there is no available information about the impact of liver pathology on the transporter levels and function.
Justyna Grzegółkowska, Kurzawski, Mateusz, Marek Droździk, Miętkiewski, Janusz, Oswald, Stefan, Post, Mariola, Mariola Post, Domagała, Pawel, Grzegółkowska, Justyna, Janusz Miętkiewski, Szeląg-Pieniek, Sylwia, Joanna Łapczuk-Romańska, Łapczuk-Romańska, Joanna, Sylwia Szeląg-Pieniek, Droździk, Marek, Pawel Domagała, Stefan Oswald, Mateusz Kurzawski   +17 more
core   +1 more source

The Effect of High-Intensity Interval Training in the Presence of L-Carnitine on the Expression of MCT1, PGC-1, and CS in the Liver of Male Wistar Rats [PDF]

Journal of Kerman University of Medical Sciences
Background: T Liver oxidative metabolism disorder is dependent on several factors that lead to liver diseases like non-alcoholic fatty liver disease.
Mahdiyeh Haj Hosseini, Beydolah Shahouzehi, Najmeh Sadat Hosseini   +2 more
doaj   +1 more source

Oncogenic Chromatin Modifier KAT2A Activates MCT1 to Drive the Glycolytic Process and Tumor Progression in Renal Cell Carcinoma

Frontiers in Cell and Developmental Biology, 2021
ObjectivesThis study aims to investigate the underlying mechanisms of KAT2A/MCT1 axis in renal cell carcinoma (RCC), providing potential therapeutic targets.MethodsWe obtained the expression data of KAT2A and MCT1 from The Cancer Genome Atlas Kidney ...
Yuanyuan Guo, Beibei Liu, Yihan Liu, Wei Sun, Wuyue Gao, Shilong Mao, Li Chen   +6 more
doaj   +1 more source

MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4 [PDF]

, 2016
SummaryMonocarboxylate transporter 1 (MCT1) inhibition is thought to block tumor growth through disruption of lactate transport and glycolysis. Here, we show MCT1 inhibition impairs proliferation of glycolytic breast cancer cells co-expressing MCT1 and ...
Gardner, Brian K, Gu, Wen, Graeber, Thomas G, Krotee, Pascal AL, Horvath, Steve, Alavi, Mohammed, Chia, David, Graham, Nicholas A, Critchlow, Susan E, Mellinghoff, Ingo K, Goodglick, Lee, Camacho, Carolina Espindola, Christofk, Heather R, Maresh, Erin L, Bagryanova, Lora, Dubinett, Steven M, Kurdistani, Siavash K, Mah, Vei, Hurvitz, Sara A, Braas, Daniel, Hong, Candice Sun, Behbahan, Iman Saramipoor   +21 more
core   +1 more source

Association between MCT1 T1470A polymorphism and climbing status in Polish and Japanese climbers [PDF]

, 2020
Sport climbing will become an official event at the 2020 Tokyo Olympics; it is a popular wilderness sport among athletes and amateurs. Our previous study suggested that the T1470A polymorphism (rs1049434) of the monocarboxylate transporter 1 (MCT1) gene ...
Majcher, Piotr, Paweł Cięszczyk, Massidda, Myosotis, Nakazato, Koichi, Takanobu Okamoto, Piotr Majcher, Mika Saito, Okamoto, Takanobu, Saito, Mika, Kikuchi, Naoki, Cięszczyk, Paweł, Koichi Nakazato, Myosotis Massidda, Ginszt, Michał, Michał Ginszt, Naoki Kikuchi   +15 more
core   +1 more source

التنوع الجيني لجين MCT1 عند لاعبي الهوکي [PDF]

Al-Mağallah Al-ʿilmiyyaẗ Lil Buḥūṯ wa Al-Dirāsāt fi Al-Tarbiyyaẗ Al-Riyaḍiyyaẗ, 2022
يهدف البحث إلى التعرف على التنوع الجيني السائد و البرايمر الخاص بجين MCT1  لدى لاعبي الهوکي. تساؤل البحث: هل هناک تنوع جيني سائد لجين MCT1  خاص بلاعبي الهوکي. منهج البحث:استخدم الباحثون المنهج الوصفى لمناسبته لطبيعة البحث .مجتمع وعينة البحث: قام الباحثون
فاطمة خالد جابر سعدة, أ.م.د / أحمد عبد الله أحمد حرات, أ.م.د/أحمد السيد محمد بطل عبد الخالق, أ.د/ رائد حلمى رمضان   +3 more
doaj   +1 more source

H3K9ac and HDAC2 Activity Are Involved in the Expression of Monocarboxylate Transporter 1 in Oligodendrocyte

Frontiers in Molecular Neuroscience, 2017
Recently, it is reported that monocarboxylate transporter 1 (MCT1) plays crucial role in oligodendrocyte differentiation and myelination. We found that MCT1 is strongly expressed in oligodendrocyte but weakly expressed in oligodendrocyte precursors (OPCs)
Qingwei Lai, Qingwei Lai, Wantong Du, Jian Wu, Xiao Wang, Xiao Wang, Xinyu Li, Xuebin Qu, Xiuxiang Wu, Fuxing Dong, Ruiqin Yao, Hongbin Fan, Hongbin Fan   +12 more
doaj   +1 more source