Results 11 to 20 of about 10,143 (187)

Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion. [PDF]

Glia
ABSTRACT We recently reported that the loss of oligodendrocyte metabolic support through the lactate and pyruvate transporter Monocarboxylate Transporter 1 (MCT1) is well tolerated into adulthood. Only with advanced aging did we observe axonal degeneration and hypomyelination due to the loss of MCT1 from oligodendroglia lineage cells.
Philips T, Thompson EG, Spead O, Vijayakumar BG, Kent ER, Miller SJ, Nwokeleme T, Vidensky S, Farah MH, Rothstein JD.   +9 more
europepmc   +4 more sources

The effect of pre-exercise alkalosis on lactate/pH regulation and mitochondrial respiration following sprint-interval exercise in humans

Frontiers in Physiology, 2023
Purpose: The purpose of this study was to evaluate the effect of pre-exercise alkalosis, induced via ingestion of sodium bicarbonate, on changes to lactate/pH regulatory proteins and mitochondrial function induced by a sprint-interval exercise session in
Claire Thomas, Claire Thomas, Rémi Delfour‐Peyrethon, Rémi Delfour‐Peyrethon, Karen Lambert, Cesare Granata, Cesare Granata, Cesare Granata, Cesare Granata, Thomas Hobbs, Christine Hanon, Christine Hanon, David J. Bishop   +12 more
doaj   +1 more source

Monocarboxylate Transporter 1 (MCT1) in Liver Pathology [PDF]

International Journal of Molecular Sciences, 2020
Membrane monocarboxylate transporter 1 (SLC16A1/MCT1) plays an important role in hepatocyte homeostasis, as well as drug handling. However, there is no available information about the impact of liver pathology on the transporter levels and function. The study was aimed to quantify SLC16A1 mRNA (qRT-PCR) and MCT1 protein abundance (liquid chromatography–
Marek Droździk, Sylwia Szeląg-Pieniek, Justyna Grzegółkowska, Joanna Łapczuk-Romańska, Mariola Post, Pawel Domagała, Janusz Miętkiewski, Stefan Oswald, Mateusz Kurzawski   +8 more
openaire   +2 more sources

Alpha-cyano-4-hydroxycinnamic acid alleviates renal fibrosis and inflammation in chronic kidney disease

All Life, 2023
Renal fibrosis is a crucial pathological phenomenon of chronic kidney disease (CKD) that contributes to the progressive loss of renal function. Monocarboxylate transporter 1 (MCT1) plays an important role in clear cell renal cell carcinoma; however, the ...
Meng Pan, Hua Wang, Weixian Chen, Weisong Jin   +3 more
doaj   +1 more source

Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration [PDF]

Frontiers in Pharmacology, 2013
The glycolytic end-product lactate is a pleiotropic tumor growth-promoting factor. Its activities primarily depend on its uptake, a process facilitated by the lactate-proton symporter monocarboxylate transporter 1 (MCT1). Therefore, targeting the transporter or its chaperon protein CD147/basigin, itself involved in the aggressive malignant phenotype ...
De Saedeleer CJ, Porporato PE, Copetti T, Pérez-Escuredo J, Payen VL, Brisson L, Feron O, Sonveaux P   +7 more
openaire   +2 more sources

A Common Polymorphism of the MCT1 Gene and Athletic Performance [PDF]

International Journal of Sports Physiology and Performance, 2014
Purpose:In red skeletal muscle, monocarboxylate transporter 1 (MCT1) is required for lactate to enter the myocytes for oxidation. The A1470T polymorphism (rs1049434) in the MCT1 gene was shown to be associated with lactate transport rates in human skeletal muscles.
Fedotovskaya, ON, Mustafina, LJ, Popov, DV, Vinogradova, OL, Ahmetov, II   +4 more
openaire   +5 more sources

Immunoreactivity and a new staining method of monocarboxylate transporter 1 located in endothelial cells of cerebral vessels of human brain in distinguishing cerebral venules from arterioles

European Journal of Histochemistry, 2021
Distinguishing brain venules from arterioles with arteriolosclerosis is less reliable using traditional staining methods. We aimed to immunohistochemically assess the monocarboxylate transporter 1 (MCT1), a specific marker of venous endothelium found in ...
Yuan Cao, Dong-Hui Ao, Chao Ma, Wen-Ying Qiu, Yi-Cheng Zhu   +4 more
doaj   +1 more source

Impact of MCT1 Haploinsufficiency on the Mouse Retina [PDF]

, 2018
The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1 +/- heterozygotes, which express half of the normal complement of MCT1. The MCT1 +/- retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels
Peachey, Neal S., Yu, Minzhong, Han, John Y. S., Lengacher, Sylvain, Magistretti, Pierre J., Pellerin, Luc, Philp, Nancy J.   +6 more
openaire   +5 more sources

Monocarboxylate Transporter-1 (MCT1)-Mediated Lactate Uptake Protects Pancreatic Adenocarcinoma Cells from Oxidative Stress during Glutamine Scarcity Thereby Promoting Resistance against Inhibitors of Glutamine Metabolism

Antioxidants, 2023
Metabolic compartmentalization of stroma-rich tumors, like pancreatic ductal adenocarcinoma (PDAC), greatly contributes to malignancy. This involves cancer cells importing lactate from the microenvironment (reverse Warburg cells) through monocarboxylate ...
Nourhane Ammar, Maya Hildebrandt, Claudia Geismann, Christian Röder, Timo Gemoll, Susanne Sebens, Ania Trauzold, Heiner Schäfer   +7 more
doaj   +1 more source

MCT1 confirmed in rat striated muscle mitochondria [PDF]

Journal of Applied Physiology, 2004
We sought to test the hypothesis that monocarboxylate transporter isoform 1 (MCT1) is the inner mitochondrial membrane lactate/pyruvate transporter, and, as such, contributes to functioning of the intracellular lactate shuttle. However, presence of a mammalian mitochondrially localized MCT1 (mMCT1) has been contested.
C Eric, Butz, Grant B, McClelland, George A, Brooks   +2 more
openaire   +2 more sources