Results 41 to 50 of about 13,060 (191)

Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1

, 1999
To evaluate the potential role of monocarboxylate transporter-1 (MCT1) in tissue lactate oxidation, isolated rat subsarcolemmal and interfibrillar cardiac and skeletal muscle mitochondria were probed with an antibody to MCT1.
C. E. Butz, Marcia A. Brown, George A. Brooks, James P. Sicurello, Hervé Dubouchaud   +4 more
core   +1 more source

Nrf2 Activation Enhances Muscular MCT1 Expression and Hypoxic Exercise Capacity

, 2020
Introduction Skeletal muscle is the major producing and metabolizing site of lactic acid. A family of monocarboxylate transporter (MCT) proteins, especially MCT1 and MCT4, are involved in the lactate–pyruvate exchange and metabolism.
Zhu, Rongxin, Yu, Siwang, JIANXIONG WANG, Wang, Jiahui, LINJIA WANG, YING ZHANG, RONGXIN ZHU, JIAHUI WANG, SIWANG YU, Zhang, Ying, Wang, Jianxiong, Wang, Linjia   +11 more
core   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Redistribution of Monocarboxylate 1 and 4 in Hippocampus and Spatial Memory Impairment Induced by Long-term Ketamine Administration

Frontiers in Behavioral Neuroscience, 2020
The monocarboxylate transporters (MCTs) MCT1, MCT2, and MCT4 are essential components of the astrocyte-neuron lactate shuttle (ANLS), which is a fundamental element of brain energetics. Decreased expression of MCTs can induce cognitive dysfunction of the
Runtao Ding, Runtao Ding, Yaqing Tan, Ao Du, Gehua Wen, Xinghua Ren, Hui Yao, Weishu Ren, Huairu Liu, Xiaolong Wang, Hao Yu, Jun Yao, Baoman Li, Guohua Zhang, Yan Lu, Xu Wu   +15 more
doaj   +1 more source

Putative Role of MCT1 rs1049434 Polymorphism in High-Intensity Endurance Performance: Concept and Basis to Understand Possible Individualization Stimulus

Sports, 2021
Monocarboxylate transporters (MCTs) have been proposed as important mediators of the exchange between lactate (La−) producer and La− recipient (consumer) cells.
Xavier Ramírez de la Piscina-Viúdez, Jesús Álvarez-Herms, Diego A. Bonilla, Arkaitz Castañeda-Babarro, Jon Larruskain, Julen Díaz-Ramírez, Ildus I. Ahmetov, Alex Martínez-Ascensión, Richard B. Kreider, Adrián Odriozola-Martínez   +9 more
doaj   +1 more source

Role of the lactate transporter (MCT1) in skeletal muscles

, 1996
We used an antibody, constructed against the monocarboxylate transporter 1 (MCT1) protein (L. Carpenter, R. C. Poole, and A. P. Halestrap. Biochim. Biophys.
K. J. McCullagh, M. O'Brien, A. Bonen, R. C. Poole, A. P. Halestrap   +4 more
core   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

The Relationship of Blood Lactate Level and Swimming Performance with MCT1 after Critical Velocity [PDF]

Annals of Applied Sport Science
Background. The investigation into whether the MCT1 gene in swimming and the inclusion of exercises involving critical velocity in water warm-ups have an effect on performance is ongoing. Objectives.
Benil Kistak Altan, Hatice Ilhan Odabas, Mehmet Tolgahan Hakan, Sakir Umit Zeybek   +3 more
doaj  

Laktaattikuljettajat MCT1 ja MCT2 aasin punasolun solukalvolla [PDF]

, 2014
Kovassa rasituksessa lihassoluissa muodostuu laktaattia niiden joutuessa työskentelemään anaerobisesti. Kun laktaatin tuotto ylittää kulutuksen, alkaa kudokseen kertyä laktaattia ja vetyioneja.
Leppänen, Viivianna
core  

Histone Lactylation Drives WNK1 Expression to Promote Esophageal Squamous Cell Carcinoma Progression Through Histone H3 Ser10 Phosphorylation

Advanced Science, EarlyView.
In brief. Yan et al. demonstrated that the excess lactate produced by the enhanced glycolysis pathway in esophageal cancer can lactylate H3K23, H3K23la can be enriched in the WNK1 promoter region to promote WNK1 expression, thereby increasing the phosphorylation of the p‐H3 Ser10 site, and p‐H3S10 can be enriched in the AKT1 promoter region to promote ...
Mingyang Yan, Shaobo Fang, Yanming Song, Lei Zhang, Kexin Zhao, Zhenwei Wang, Yang Shao, Meng Liu, Xinyang Jia, Qinxin Guo, Mee‐Hyun Lee, Guoguo Jin, Zigang Dong   +12 more
wiley   +1 more source