Results 31 to 40 of about 10,143 (187)

Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis

Journal of Orthopaedic Surgery and Research, 2023
Background Osteosarcoma is the most common primary malignant bone tumor in adolescents and children and prone to develop lung metastasis. Its prognosis has been virtually unimproved over the last few decades, especially in patients with metastases, who ...
Gaohong Sheng, Yuan Gao, Hua Wu, Yang Liu, Yong Yang   +4 more
doaj   +1 more source

Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells

Journal of Experimental & Clinical Cancer Research, 2018
Background Autophagy is a dynamic physiological process that can generate energy and nutrients for cell survival during stress. Autophagy can regulate the migration and invasive ability in cancer cells.
Qing Fan, Liang Yang, Xiaodong Zhang, Yingbo Ma, Yan Li, Lei Dong, Zhihong Zong, Xiangdong Hua, Dongming Su, Hangyu Li, Jingang Liu   +10 more
doaj   +1 more source

Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes

Genes, 2022
Background: To date, nearly 300 genetic markers were linked to endurance and power/strength traits. The current study aimed to compare genotype distributions and allele frequencies of the common polymorphisms: MCT1 rs1049434, NRF2 rs12594956, MYBPC3 rs1052373 and HFE rs1799945 in Polish elite athletes versus nonathletes. Methods: The study involved 101
Magdalena Dzitkowska-Zabielska, Aleksandra Bojarczuk, Małgorzata Borczyk, Marcin Piechota, Michał Korostyński, Jakub Grzegorz Adamczyk, Grzegorz Trybek, Myosotis Massidda, Paweł Cięszczyk   +8 more
openaire   +2 more sources

MCT1 regulates aggressive and metabolic phenotypes in bladder cancer [PDF]

Journal of Cancer, 2018
Background: Monocarboxylate transporter isoform 1 (MCT1) is an important molecule in mediating lactate transportation. Recent studies have shown an oncogenic role of MCT1 in cancer development. Methods: In this study, we aimed to investigate the expression and role of MCT1 in bladder cancer (BCa).
Zhang, Guiming, Zhang, Yongjian, Dong, Dahai, Wang, Fangming, Ma, Xiaocheng, Guan, Fengju, Sun, Lijiang   +6 more
openaire   +2 more sources

Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus

Neurobiology of Disease, 2011
Monocarboxylate transporter 1 (MCT1) facilitates the transport of important metabolic fuels (lactate, pyruvate and ketone bodies) and possibly also acidic drugs such as valproic acid across the blood–brain barrier.
Fredrik Lauritzen, Nihal C. de Lanerolle, Tih-Shih W. Lee, Dennis D. Spencer, Jung H. Kim, Linda H. Bergersen, Tore Eid   +6 more
doaj   +1 more source

Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy

Neurobiology of Disease, 2012
Monocarboxylate transporter 1 (MCT1) facilitates the transport of monocarboxylate fuels (lactate, pyruvate and ketone bodies) and acidic drugs, such as valproic acid, across cell membranes.
Fredrik Lauritzen, Edgar L. Perez, Eric R. Melillo, Jung-Min Roh, Hitten P. Zaveri, Tih-Shih W. Lee, Yue Wang, Linda H. Bergersen, Tore Eid   +8 more
doaj   +1 more source

Lactic Acid Permeability of Aquaporin-9 Enables Cytoplasmic Lactate Accumulation via an Ion Trap

Life, 2022
(1) Background: Human aquaporin-9 (AQP9) conducts several small uncharged metabolites, such as glycerol, urea, and lactic acid. Certain brain tumors were shown to upregulate AQP9 expression, and the putative increase in lactic acid permeability was ...
Katharina Geistlinger, Jana D. R. Schmidt, Eric Beitz   +2 more
doaj   +1 more source

Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. [PDF]

PLoS Pathogens, 2016
Merkel cell polyomavirus (MCPyV) is an etiological agent of Merkel cell carcinoma (MCC), a highly aggressive skin cancer. The MCPyV small tumor antigen (ST) is required for maintenance of MCC and can transform normal cells.
Christian Berrios, Megha Padi, Mark A Keibler, Donglim Esther Park, Vadim Molla, Jingwei Cheng, Soo Mi Lee, Gregory Stephanopoulos, John Quackenbush, James A DeCaprio   +9 more
doaj   +1 more source

Monocarboxylate transporters 1-4 in NSCLC: MCT1 is an independent prognostic marker for survival.

PLoS ONE, 2014
IntroductionMonocarboxylate transporters (MCTs) 1-4 are lactate transporters crucial for cancers cells adaption to upregulated glycolysis. Herein, we aimed to explore their prognostic impact on disease-specific survival (DSS) in both cancer and tumor ...
Marte Eilertsen, Sigve Andersen, Samer Al-Saad, Yury Kiselev, Tom Donnem, Helge Stenvold, Ingvild Pettersen, Khalid Al-Shibli, Elin Richardsen, Lill-Tove Busund, Roy M Bremnes   +10 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source