Results 31 to 40 of about 13,060 (191)

Lactic Acid Permeability of Aquaporin-9 Enables Cytoplasmic Lactate Accumulation via an Ion Trap

Life, 2022
(1) Background: Human aquaporin-9 (AQP9) conducts several small uncharged metabolites, such as glycerol, urea, and lactic acid. Certain brain tumors were shown to upregulate AQP9 expression, and the putative increase in lactic acid permeability was ...
Katharina Geistlinger, Jana D. R. Schmidt, Eric Beitz   +2 more
doaj   +1 more source

MCT1 mRNA and protein expression levels in tissues from MCT1^+/+ vs. MCT1^+/− mice and comparative histological analysis.

, 2013
(A) Quantitative RT-PCR analysis of relative MCT1 mRNA levels in tissues collected from MCT1+/− and MCT1+/+ mice. Values are expressed as percentage and represent the mean normalized MCT1 mRNA level in MCT1+/− mouse tissue compared to the mean normalized
François Pralong (202345), Jean-Christophe Stehle (66239), Laure Dix (499052), Frédéric Preitner (499051), Bernard Thorens (120953), Pierre J. Magistretti (143663), Nadia Steiner (499049), Céline Favrod (499050), Lionel Carneiro (435208), Luc Pellerin (75905), Touria Nehiri-Sitayeb (499048), Sylvain Lengacher (499047)   +11 more
core   +1 more source

Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. [PDF]

PLoS Pathogens, 2016
Merkel cell polyomavirus (MCPyV) is an etiological agent of Merkel cell carcinoma (MCC), a highly aggressive skin cancer. The MCPyV small tumor antigen (ST) is required for maintenance of MCC and can transform normal cells.
Christian Berrios, Megha Padi, Mark A Keibler, Donglim Esther Park, Vadim Molla, Jingwei Cheng, Soo Mi Lee, Gregory Stephanopoulos, John Quackenbush, James A DeCaprio   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation [PDF]

, 2021
Background Triple negative breast cancer (TNBC) poses a serious clinical challenge as it is an aggressive form of the disease that lacks estrogen receptor, progesterone receptor, and ERBB2 (formerly HER2) gene amplification, which limits the treatment ...
Thomas, Eloise, Carlisle, Robert, Hauton, David, Walsby-Tickle, John, Lakshminarayanan, Abirami, Able, Sarah, Vallis, Katherine, Owen, Joshua, Skaripa-Koukelli, Irini, Mccullagh, James, Robert C. Carlisle, Abirami Lakshminarayanan, Irini Skaripa-Koukelli, David Hauton, James McCullagh, John Walsby-Tickle, Sarah Able, Katherine A. Vallis, Eloïse Thomas, Joshua Owen   +19 more
core   +1 more source

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

Monocarboxylate transporters 1-4 in NSCLC: MCT1 is an independent prognostic marker for survival.

PLoS ONE, 2014
IntroductionMonocarboxylate transporters (MCTs) 1-4 are lactate transporters crucial for cancers cells adaption to upregulated glycolysis. Herein, we aimed to explore their prognostic impact on disease-specific survival (DSS) in both cancer and tumor ...
Marte Eilertsen, Sigve Andersen, Samer Al-Saad, Yury Kiselev, Tom Donnem, Helge Stenvold, Ingvild Pettersen, Khalid Al-Shibli, Elin Richardsen, Lill-Tove Busund, Roy M Bremnes   +10 more
doaj   +1 more source

Fat mass accumulation and distribution in MCT1^+/+ and MCT1^+/− mice fed a normal chow or high fat diet.

, 2013
(A) Fat mass changes in MCT1+/+ and MCT1+/− mice fed a normal chow or a high fat diet for different periods of time. Results are mean ± SEM, n = 4-9. Asterisks represent a statistically significant difference between MCT1+/+ and MCT1+/− mice evaluated ...
François Pralong (202345), Jean-Christophe Stehle (66239), Laure Dix (499052), Frédéric Preitner (499051), Bernard Thorens (120953), Pierre J. Magistretti (143663), Nadia Steiner (499049), Céline Favrod (499050), Lionel Carneiro (435208), Luc Pellerin (75905), Touria Nehiri-Sitayeb (499048), Sylvain Lengacher (499047)   +11 more
core   +1 more source

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis [preprint] [PDF]

, 2023
This article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review.Circulating lactate is a fuel source for liver metabolism but may exacerbate metabolic diseases such as nonalcoholic steatohepatitis (NASH).
Yenilmez, Batuhan, Kelly, Mark, Bramato, Brianna, Min, Kyounghee, Harney, Shauna M, Rothstein, Jeffery D, Morrision, Brett, DiMarzio, Chloe, Elleby, Michael, McHugh, Nicholas, Tsagkaraki, Emmanouela, Echeverria, Dimas, Czech, Michael P, Raymond, Naideline, Khvorova, Anastasia, Lifshitz, Lawrence M   +15 more
core   +1 more source

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source