Results 21 to 30 of about 10,143 (187)

Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes [PDF]

Circulation Research, 2021
Rationale: CAV3 (caveolin3) variants associated with arrhythmogenic cardiomyopathy and muscular dystrophy can disrupt post-Golgi surface trafficking. As CAV1 (caveolin1) was recently identified in cardiomyocytes, we hypothesize that conserved isoform-specific protein/protein interactions orchestrate unique cardiomyocyte ...
Jonas Peper, Daniel Kownatzki-Danger, Gunnar Weninger, Fitzwilliam Seibertz, Julius Ryan D. Pronto, Henry Sutanto, David Pacheu-Grau, Robin Hindmarsh, Sören Brandenburg, Tobias Kohl, Gerd Hasenfuss, Michael Gotthardt, Eva A. Rog-Zielinska, Bernd Wollnik, Peter Rehling, Henning Urlaub, Jörg Wegener, Jordi Heijman, Niels Voigt, Lukas Cyganek, Christof Lenz, Stephan E. Lehnart   +21 more
openaire   +7 more sources

Oncogenic Chromatin Modifier KAT2A Activates MCT1 to Drive the Glycolytic Process and Tumor Progression in Renal Cell Carcinoma

Frontiers in Cell and Developmental Biology, 2021
ObjectivesThis study aims to investigate the underlying mechanisms of KAT2A/MCT1 axis in renal cell carcinoma (RCC), providing potential therapeutic targets.MethodsWe obtained the expression data of KAT2A and MCT1 from The Cancer Genome Atlas Kidney ...
Yuanyuan Guo, Beibei Liu, Yihan Liu, Wei Sun, Wuyue Gao, Shilong Mao, Li Chen   +6 more
doaj   +1 more source

The Effect of High-Intensity Interval Training in the Presence of L-Carnitine on the Expression of MCT1, PGC-1, and CS in the Liver of Male Wistar Rats [PDF]

Journal of Kerman University of Medical Sciences
Background: T Liver oxidative metabolism disorder is dependent on several factors that lead to liver diseases like non-alcoholic fatty liver disease.
Mahdiyeh Haj Hosseini, Beydolah Shahouzehi, Najmeh Sadat Hosseini   +2 more
doaj   +1 more source

التنوع الجيني لجين MCT1 عند لاعبي الهوکي [PDF]

Al-Mağallah Al-ʿilmiyyaẗ Lil Buḥūṯ wa Al-Dirāsāt fi Al-Tarbiyyaẗ Al-Riyaḍiyyaẗ, 2022
يهدف البحث إلى التعرف على التنوع الجيني السائد و البرايمر الخاص بجين MCT1  لدى لاعبي الهوکي. تساؤل البحث: هل هناک تنوع جيني سائد لجين MCT1  خاص بلاعبي الهوکي. منهج البحث:استخدم الباحثون المنهج الوصفى لمناسبته لطبيعة البحث .مجتمع وعينة البحث: قام الباحثون
فاطمة خالد جابر سعدة, أ.م.د / أحمد عبد الله أحمد حرات, أ.م.د/أحمد السيد محمد بطل عبد الخالق, أ.د/ رائد حلمى رمضان   +3 more
doaj   +1 more source

MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4

Cell Reports, 2016
Monocarboxylate transporter 1 (MCT1) inhibition is thought to block tumor growth through disruption of lactate transport and glycolysis. Here, we show MCT1 inhibition impairs proliferation of glycolytic breast cancer cells co-expressing MCT1 and MCT4 via disruption of pyruvate rather than lactate export. MCT1 expression is elevated in glycolytic breast
Hong, Candice Sun, Graham, Nicholas A, Gu, Wen, Camacho, Carolina Espindola, Mah, Vei, Maresh, Erin L, Alavi, Mohammed, Bagryanova, Lora, Krotee, Pascal AL, Gardner, Brian K, Behbahan, Iman Saramipoor, Horvath, Steve, Chia, David, Mellinghoff, Ingo K, Hurvitz, Sara A, Dubinett, Steven M, Critchlow, Susan E, Kurdistani, Siavash K, Goodglick, Lee, Braas, Daniel, Graeber, Thomas G, Christofk, Heather R   +21 more
openaire   +4 more sources

The metabolic microenvironment of melanomas: Prognostic value of MCT1 and MCT4 [PDF]

Cell Cycle, 2016
BRAF mutations are known drivers of melanoma development and, recently, were also described as players in the Warburg effect, while this reprogramming of energy metabolism has been identified as a possible strategy for treating melanoma patients.
Céline, Pinheiro, Vera, Miranda-Gonçalves, Adhemar, Longatto-Filho, Anna L S A, Vicente, Gustavo N, Berardinelli, Cristovam, Scapulatempo-Neto, Ricardo F A, Costa, Cristiano R, Viana, Rui M, Reis, Fátima, Baltazar, Vinicius L, Vazquez   +10 more
openaire   +3 more sources

H3K9ac and HDAC2 Activity Are Involved in the Expression of Monocarboxylate Transporter 1 in Oligodendrocyte

Frontiers in Molecular Neuroscience, 2017
Recently, it is reported that monocarboxylate transporter 1 (MCT1) plays crucial role in oligodendrocyte differentiation and myelination. We found that MCT1 is strongly expressed in oligodendrocyte but weakly expressed in oligodendrocyte precursors (OPCs)
Qingwei Lai, Qingwei Lai, Wantong Du, Jian Wu, Xiao Wang, Xiao Wang, Xinyu Li, Xuebin Qu, Xiuxiang Wu, Fuxing Dong, Ruiqin Yao, Hongbin Fan, Hongbin Fan   +12 more
doaj   +1 more source

miR-124 Suppresses Pancreatic Ductal Adenocarcinoma Growth by Regulating Monocarboxylate Transporter 1-Mediated Cancer Lactate Metabolism

Cellular Physiology and Biochemistry, 2018
Background/Aims: Increasing evidence shows that reprogramming of energy metabolism is a hallmark of cancer. Considering the emergence of microRNAs as crucial modulators of cancer, this study aimed to better understand the molecular mechanisms of miR-124 ...
De-Hai Wu, Hao Liang, Shou-Nan Lu, Hao Wang, Zhi-Lei Su, Lei Zhang, Jian-Qun Ma, Mian Guo, Sheng Tai, Shan Yu   +9 more
doaj   +1 more source

Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice.

PLoS ONE, 2013
The monocarboxylate transporter 1 (MCT1 or SLC16A1) is a carrier of short-chain fatty acids, ketone bodies, and lactate in several tissues. Genetically modified C57BL/6J mice were produced by targeted disruption of the mct1 gene in order to understand ...
Sylvain Lengacher, Touria Nehiri-Sitayeb, Nadia Steiner, Lionel Carneiro, Céline Favrod, Frédéric Preitner, Bernard Thorens, Jean-Christophe Stehle, Laure Dix, François Pralong, Pierre J Magistretti, Luc Pellerin   +11 more
doaj   +1 more source

Cyclosporine protects from intestinal epithelial injury by modulating butyrate uptake via upregulation of membrane monocarboxylate transporter 1 levels

Biochemistry and Biophysics Reports, 2020
Background and aims: A relationship between treatment outcomes and intestinal microbiota in patients with inflammatory bowel diseases has been demonstrated. Cyclosporine treatment leads to rapid improvement in severe ulcerative colitis.
Shinji Ota, Hirotake Sakuraba, Hiroto Hiraga, Shukuko Yoshida, Miwa Satake, Yui Akemoto, Nahoko Tanaka, Rina Watanabe, Maeda Takato, Yasuhisa Murai, Kayo Ueno, Takenori Niioka, Makoto Hayakari, Yoh Ishiguro, Shinsaku Fukuda   +14 more
doaj   +1 more source