Results 21 to 30 of about 13,060 (191)

miR-124 Suppresses Pancreatic Ductal Adenocarcinoma Growth by Regulating Monocarboxylate Transporter 1-Mediated Cancer Lactate Metabolism

Cellular Physiology and Biochemistry, 2018
Background/Aims: Increasing evidence shows that reprogramming of energy metabolism is a hallmark of cancer. Considering the emergence of microRNAs as crucial modulators of cancer, this study aimed to better understand the molecular mechanisms of miR-124 ...
De-Hai Wu, Hao Liang, Shou-Nan Lu, Hao Wang, Zhi-Lei Su, Lei Zhang, Jian-Qun Ma, Mian Guo, Sheng Tai, Shan Yu   +9 more
doaj   +1 more source

Towards the synthesis and delivery of a halogenated MCT1 substrate [PDF]

, 2020
The monocarboxylate transporter 1 (MCT1) has received special attention as a potential therapeutic target in cancer thanks to its role in lactate shuttling.
Skaripa-Koukelli, Eirini
core   +1 more source

Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice.

PLoS ONE, 2013
The monocarboxylate transporter 1 (MCT1 or SLC16A1) is a carrier of short-chain fatty acids, ketone bodies, and lactate in several tissues. Genetically modified C57BL/6J mice were produced by targeted disruption of the mct1 gene in order to understand ...
Sylvain Lengacher, Touria Nehiri-Sitayeb, Nadia Steiner, Lionel Carneiro, Céline Favrod, Frédéric Preitner, Bernard Thorens, Jean-Christophe Stehle, Laure Dix, François Pralong, Pierre J Magistretti, Luc Pellerin   +11 more
doaj   +1 more source

Cyclosporine protects from intestinal epithelial injury by modulating butyrate uptake via upregulation of membrane monocarboxylate transporter 1 levels

Biochemistry and Biophysics Reports, 2020
Background and aims: A relationship between treatment outcomes and intestinal microbiota in patients with inflammatory bowel diseases has been demonstrated. Cyclosporine treatment leads to rapid improvement in severe ulcerative colitis.
Shinji Ota, Hirotake Sakuraba, Hiroto Hiraga, Shukuko Yoshida, Miwa Satake, Yui Akemoto, Nahoko Tanaka, Rina Watanabe, Maeda Takato, Yasuhisa Murai, Kayo Ueno, Takenori Niioka, Makoto Hayakari, Yoh Ishiguro, Shinsaku Fukuda   +14 more
doaj   +1 more source

Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis

Journal of Orthopaedic Surgery and Research, 2023
Background Osteosarcoma is the most common primary malignant bone tumor in adolescents and children and prone to develop lung metastasis. Its prognosis has been virtually unimproved over the last few decades, especially in patients with metastases, who ...
Gaohong Sheng, Yuan Gao, Hua Wu, Yang Liu, Yong Yang   +4 more
doaj   +1 more source

Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells

Journal of Experimental & Clinical Cancer Research, 2018
Background Autophagy is a dynamic physiological process that can generate energy and nutrients for cell survival during stress. Autophagy can regulate the migration and invasive ability in cancer cells.
Qing Fan, Liang Yang, Xiaodong Zhang, Yingbo Ma, Yan Li, Lei Dong, Zhihong Zong, Xiangdong Hua, Dongming Su, Hangyu Li, Jingang Liu   +10 more
doaj   +1 more source

MCT1 mRNA and protein expression levels in tissues from MCT1^+/+ vs. MCT1^+/− mice following three months of high fat diet (A) Quantitative RT-PCR analysis of relative MCT1 mRNA levels in tissues collected from MCT1^+/− and MCT1^+/+ mice.

, 2013
Values are expressed as percentage and represent the mean normalized MCT1 mRNA level in MCT1+/− mouse tissue compared to the mean normalized MCT1 mRNA level in MCT1+/+ mouse tissue ± SEM, n = 4 (MCT1+/+) and 7 (MCT1+/−).
François Pralong (202345), Jean-Christophe Stehle (66239), Laure Dix (499052), Frédéric Preitner (499051), Bernard Thorens (120953), Pierre J. Magistretti (143663), Nadia Steiner (499049), Céline Favrod (499050), Lionel Carneiro (435208), Luc Pellerin (75905), Touria Nehiri-Sitayeb (499048), Sylvain Lengacher (499047)   +11 more
core   +1 more source

Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus

Neurobiology of Disease, 2011
Monocarboxylate transporter 1 (MCT1) facilitates the transport of important metabolic fuels (lactate, pyruvate and ketone bodies) and possibly also acidic drugs such as valproic acid across the blood–brain barrier.
Fredrik Lauritzen, Nihal C. de Lanerolle, Tih-Shih W. Lee, Dennis D. Spencer, Jung H. Kim, Linda H. Bergersen, Tore Eid   +6 more
doaj   +1 more source

Body weight gain for MCT1^+/+ and MCT1^+/− mice fed a normal chow or high fat diet.

, 2013
(A) Photograph of representative MCT1+/+ and MCT1+/− mice fed with a normal chow diet for 12 months (upper panel). Weight gain over time for MCT1+/+ and MCT1+/− mice fed with a normal chow diet (lower panel).
François Pralong (202345), Jean-Christophe Stehle (66239), Laure Dix (499052), Frédéric Preitner (499051), Bernard Thorens (120953), Pierre J. Magistretti (143663), Nadia Steiner (499049), Céline Favrod (499050), Lionel Carneiro (435208), Luc Pellerin (75905), Touria Nehiri-Sitayeb (499048), Sylvain Lengacher (499047)   +11 more
core   +1 more source

Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy

Neurobiology of Disease, 2012
Monocarboxylate transporter 1 (MCT1) facilitates the transport of monocarboxylate fuels (lactate, pyruvate and ketone bodies) and acidic drugs, such as valproic acid, across cell membranes.
Fredrik Lauritzen, Edgar L. Perez, Eric R. Melillo, Jung-Min Roh, Hitten P. Zaveri, Tih-Shih W. Lee, Yue Wang, Linda H. Bergersen, Tore Eid   +8 more
doaj   +1 more source