Results 51 to 60 of about 13,060 (191)

MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation

Nature Communications
Monocarboxylate transporter 1 (MCT1) exhibits essential roles in cellular metabolism and energy supply. Although MCT1 is highly expressed in activated B cells, it is not clear how MCT1-governed monocarboxylates transportation is functionally coupled to ...
Wenna Chi, Na Kang, Linlin Sheng, Sichen Liu, Lei Tao, Xizhi Cao, Ye Liu, Can Zhu, Yuming Zhang, Bolong Wu, Ruiqun Chen, Lili Cheng, Jing Wang, Xiaolin Sun, Xiaohui Liu, Haiteng Deng, Jinliang Yang, Zhanguo Li, Wanli Liu, Ligong Chen   +19 more
doaj   +1 more source

Immunhistochemical staining of MCT1–4 in NSCLC.

, 2014
Low expression: A) MCT1, B) MCT2, C) MCT3, D) MCT4. High expression: E) MCT1, F) MCT2, G) MCT3, H) MCT4. 100× and 400× magnification.
Samer Al-Saad (186401), Roy M. Bremnes (186405), Marte Eilertsen (502637), Helge Stenvold (186390), Tom Donnem (186362), Ingvild Pettersen (630403), Khalid Al-Shibli (186396), Elin Richardsen (630404), Sigve Andersen (186387), Yury Kiselev (182528), Lill-Tove Busund (186409)   +10 more
core   +1 more source

Mechanism of monocarboxylate transporter 1 promoting migration and invasion in pancreatic ductal adenocarcinoma

Zhongguo aizheng zazhi, 2019
Background and purpose: Monocarboxylate transporter 1 (MCT1) is commonly seen to be significantly overexpressed in cancer tissues that takes charge of transporting the lactate, pyruvate and their derivatives belonging to monocarboxylate in cells. However,
张　敏, 王琳娜, 孙　超
doaj  

A Heme-Binding Transcription Factor BACH1 Regulates Lactate Catabolism Suggesting a Combined Therapy for Triple-Negative Breast Cancer

Cells, 2022
The oncogenic expression or mutation of tumor suppressors drives metabolic alteration, causing cancer cells to utilize diverse nutrients. Lactate is a known substrate for cancer cells, yet the regulatory mechanisms of lactate catabolism are limited. Here,
Joselyn Padilla, Bok-Soon Lee, Karen Zhai, Bethany Rentz, Tia Bobo, Norca Maritza Dowling, Jiyoung Lee   +6 more
doaj   +1 more source

Glucose homeostasis in MCT1^+/+ and MCT1^+/− mice fed a normal chow or high fat diet.

, 2013
(A) Intraperitoneal glucose tolerance test in MCT1+/+ and MCT1+/− mice fed with a normal chow (left panel) or with a high fat diet (right panel) for 8 weeks.
François Pralong (202345), Jean-Christophe Stehle (66239), Laure Dix (499052), Frédéric Preitner (499051), Bernard Thorens (120953), Pierre J. Magistretti (143663), Nadia Steiner (499049), Céline Favrod (499050), Lionel Carneiro (435208), Luc Pellerin (75905), Touria Nehiri-Sitayeb (499048), Sylvain Lengacher (499047)   +11 more
core   +1 more source

Lactate Drives Pathological Browning of White Adipose Tissue to Aggravate Sepsis‐Associated Metabolic Disorders in a GPR81‐Dependent Manner

Advanced Science, EarlyView.
Sepsis‐triggered lactate accumulation induces pathological white adipose tissue browning. Lactate activates adipocyte GPR81 to sequentially upregulate CTRP6‐p38 signalling and UCP1 expression. This cascade exacerbates sepsis‐associated metabolic disorders.
Chunliang Zheng, Xiaohua Li, Shuo Li, Chungen Xing, Chun Cao   +4 more
wiley   +1 more source

Regulation of monocarboxylic acid transporter-1 by cAMP dependent vesicular trafficking in brain microvascular endothelial cells.

PLoS ONE, 2014
In this study, a detailed characterization of Monocarboxylic Acid Transporter-1 (Mct1) in cytoplasmic vesicles of cultured rat brain microvascular endothelial cells shows them to be a diverse population of endosomes intrinsic to the regulation of the ...
Amy L Uhernik, Lun Li, Nathan LaVoy, Micah J Velasquez, Jeffrey P Smith   +4 more
doaj   +1 more source

Developmental Expression of Monocarboxylate Transporter 1 and 4 in Rat Liver

Journal of Pharmacy & Pharmaceutical Sciences, 2019
Purpose: Monocarboxylate transporters (MCT) are proton-coupled integral membrane proteins that control the influx and efflux of endogenous monocarboxylates such as lactate, acetate and pyruvate. They also transport and mediate the clearance of drugs such
Michael Ng, Justin Louie, Jieyun Cao, Melanie A Felmlee   +3 more
doaj   +1 more source

Expression of Monocarboxylate Transporter 1 in Immunosuppressive Macrophages Is Associated With the Poor Prognosis in Breast Cancer

Frontiers in Oncology, 2020
Monocarboxylate transporter 1 (MCT1) participates in the transport of lactate to facilitate metabolic reprogramming during tumor progression.
Bei Li, Bei Li, Qian Yang, Zhiyu Li, Zhiliang Xu, Si Sun, Qi Wu, Shengrong Sun   +7 more
doaj   +1 more source

Monocarboxylate transporter MCT1 promotes tumor metastasis independently of its activity as a lactate transporter. [PDF]

, 2017
Extracellular acidosis resulting from intense metabolic activities in tumors promotes cancer cell migration, invasion and metastasis. While host cells die at low extracellular pH, cancer cells resist, as they are well equipped with transporters and ...
Vazeille, Thibaut, Caroline Bouzin, Thibaut Vazeille, Bouzin, Caroline, Pierre Sonveaux, Sonveaux, Pierre, Kristin S. Rädecke, Radecke, Kristin, Myriam Y. Hsu, Wyart, Elisabeth, Payen, Valéry, Paolo E. Porporato, Hsu, Myriam, Porporato, Paolo E., Porporato, Paolo, Elisabeth Wyart, Valéry L. Payen   +16 more
core   +1 more source