Results 51 to 60 of about 10,143 (187)
Zhongguo aizheng zazhi, 2019 Background and purpose: Monocarboxylate transporter 1 (MCT1) is commonly seen to be significantly overexpressed in cancer tissues that takes charge of transporting the lactate, pyruvate and their derivatives belonging to monocarboxylate in cells. However,
张 敏, 王琳娜, 孙 超
doaj
PLoS ONE, 2014 In this study, a detailed characterization of Monocarboxylic Acid Transporter-1 (Mct1) in cytoplasmic vesicles of cultured rat brain microvascular endothelial cells shows them to be a diverse population of endosomes intrinsic to the regulation of the ...
Amy L Uhernik +4 more
doaj +1 more source
Frontiers in Oncology, 2020 Monocarboxylate transporter 1 (MCT1) participates in the transport of lactate to facilitate metabolic reprogramming during tumor progression.
Bei Li +7 more
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Astronomische Nachrichten, EarlyView.ABSTRACT We present relative astrometric measurements of visual double stars, made in 2019 with the speckle camera PISCO at the 1‐m Epsilon telescope of the C2PU facility (Observatoire de la Côte d'Azur, Calern site). Our observing list contains orbital couples as well as double stars whose motion is still uncertain.
J.‐L. Prieur +11 more
wiley +1 more source
Developmental Expression of Monocarboxylate Transporter 1 and 4 in Rat Liver
Journal of Pharmacy & Pharmaceutical Sciences, 2019 Purpose: Monocarboxylate transporters (MCT) are proton-coupled integral membrane proteins that control the influx and efflux of endogenous monocarboxylates such as lactate, acetate and pyruvate. They also transport and mediate the clearance of drugs such
Michael Ng +3 more
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Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
Cells, 2022 The oncogenic expression or mutation of tumor suppressors drives metabolic alteration, causing cancer cells to utilize diverse nutrients. Lactate is a known substrate for cancer cells, yet the regulatory mechanisms of lactate catabolism are limited. Here,
Joselyn Padilla +6 more
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Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells
Interdisciplinary Medicine, EarlyView.Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen +6 more
wiley +1 more source
A MONOCARBOXYLATE TRANSPORTER MCT1 IS LOCATED AT THE BASOLATERAL POLE OF RAT JEJUNUM [PDF]
Experimental Physiology, 1999 SUMMARYWe have functionally expressed and identified a monocarboxylate transporter (MCT1) from rat jejunal enterocyte and we provide evidence for its basolateral localization. Poly(A)+ RNA isolated from rat jejunum was injected into Xenopus laevis oocytes and expression of a proton‐lactate symporter was investigated by means of L‐[14C]lactate uptake ...
ORSENIGO MN +4 more
openaire +3 more sources
Scientific Reports, 2021 Treatment of locally advanced, unresectable head and neck squamous cell carcinoma (HNSCC) often yields only modest results with radiochemotherapy (RCT) as standard of care.
Martin Leu +7 more
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