Results 61 to 70 of about 13,060 (191)

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source

Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice

, 2017
The purpose of this study was to investigate the effects of a partial suppression of monocarboxylate transporter (MCT)-1 on skeletal muscle pH, energetics, and function (MCT1(+/-) mice).
Magistretti, P., Yann Le Fur, Vilmen, C., Lengacher, Sylvain, Bernard, M., Magistretti, Pierre, Chatel, Benjamin, Sylvain Lengacher, Bendahan, D., Hourdé, C., Bendahan, David, Lengacher, S., Messonnier, Laurent A., Pierre Magistretti, Messonnier, Laurent, Magistretti, Pierre J., Hourdé, Christophe, Christophe Hourdé, Le Fur, Y., Laurent A. Messonnier, Messonnier, L.A., Vilmen, Christophe, Christophe Vilmen, Monique Bernard, Chatel, B., Le Fur, Yann, Pellerin, L., Bernard, Monique, David Bendahan, Luc Pellerin, Pellerin, Luc, Benjamin Chatel, Bernard M, Chatel B, Le Fur Y, Messonnier LA, Bendahan D, Lengacher S, Hourdé C, Vilmen C, Magistretti P, Pellerin L   +41 more
core   +1 more source

Hyperoxia induces glucose metabolism reprogramming and intracellular acidification by suppressing MYC/MCT1 axis in lung cancer

, 2023
The perils and promises of inspiratory hyperoxia (IH) in oncology are still controversial, especially for patients with lung cancer. Increasing evidence shows that hyperoxia exposure is relevant to the tumor microenvironment.
Chang Chen, Xichun Qin, Caili Jia, Hao Zhang, Xiucheng Liu, Zhixiang Chao, Hao Qin, Li Zhang, Chao, Zhixiang, Qin, Xichun, Zhang, Li, Zhang, Hao, Chen, Chang, Qin, Hao, Liu, Xiucheng, Jia, Caili   +15 more
core   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar

Nature Communications
Hypertrophic scar (HS) is a fibroproliferative disorder characterized by fibroblast hyperactivation and aberrant extracellular matrix deposition. This study identifies macrophage-derived lactate as a key mediator of fibroblast phenotypic remodeling via ...
Yixuan Yuan, Yujie Xiao, Jie Zou, Liang Luo, Mengyang Li, Kuo Shen, Lai Wei, Yihao Zhang, Peng Wang, Yan Chen, Shixuan Zhuo, Hao Zhang, Shijie Song, Yanhui Jia, Kejia Wang, Shiqing Jiang, Hao Guan, Dahai Hu   +17 more
doaj   +1 more source

Monocarboxylate transporter-1 (MCT1) protein expression in head and neck cancer affects clinical outcome

Scientific Reports, 2021
Treatment of locally advanced, unresectable head and neck squamous cell carcinoma (HNSCC) often yields only modest results with radiochemotherapy (RCT) as standard of care.
Martin Leu, J. Kitz, Y. Pilavakis, S. Hakroush, H. A. Wolff, M. Canis, S. Rieken, M. A. Schirmer   +7 more
doaj   +1 more source

Mct1 is apparent in cytoplasmic vesicles.

, 2014
RBE4 cells expressing mCherry-Mct1 were imaged live using confocal microscopy (A). In the last three micrographs, RBE4 cells were immunostained with an anti-Mct1 antibody, fixed in 3.7% formaldehyde, and permeabilized with either methanol and acetone (B),
Jeffrey P. Smith (509882), Micah J. Velasquez (509881), Amy L. Uhernik (509879), Nathan LaVoy (509880), Lun Li (155358)   +4 more
core   +1 more source

Proteomic and Metabolomic Profiling Reveal Mitochondrial Transplantation–Mediated Reprogramming in Gastric Cancer Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mitochondria provide multiple functions for cellular physiology. Transplantation of mitochondria isolated from gastric epithelial cells GES‐1 reducing the malignancy of gastric cancer cells AGS was previously reported. To elucidate the underlying mechanisms, TMT‐based proteomic analysis coupling ingenuity pathway software prediction revealed ...
Ping‐Chen Chen, Chen‐Kai Liu, Ching‐Chung Tsai, Erna Sulistyowati, Fu‐An Li, Chung‐Jung Liu, Deng‐Chyang Wu, Shih‐Hsuan Chou, Fu‐Chen Kuo, Bin Huang   +9 more
wiley   +1 more source

Exometabolomics Reveals Metabolic Modulation Induced by Chia Oil Supplementation in Adipose Tissue Explants From Obese Mice

Lipids, EarlyView.
The experimental design and the exometabolomic findings obtained by 1H‐NMR analysis of conditioned media from subcutaneous (SAT) and epididymal adipose tissue (EAT) explants of control and obese mice supplemented with chia oil (1.5% (w/w)). Following 8 weeks of control or high‐fat diet and 5 weeks of chia oil supplementation, SAT and EAT explants were ...
Gilson Costa dos Santos Jr, Agatha Assis‐Ferreira, Gabrielly Muniz‐Cassuce, Tatiana El Bacha, Christina Barja‐Fidalgo, Simone Vargas da Silva   +5 more
wiley   +1 more source

Deciphering metabolic heterogeneity in retinoblastoma unravels the role of monocarboxylate transporter 1 in tumor progression

Biomarker Research
Background Tumors exhibit metabolic heterogeneity, influencing cancer progression. However, understanding metabolic diversity in retinoblastoma (RB), the primary intraocular malignancy in children, remains limited.
Junjie Tang, Yaoming Liu, Yinghao Wang, Zhihui Zhang, Jiahe Nie, Xinyue Wang, Siming Ai, Jinmiao Li, Yang Gao, Cheng Li, Chao Cheng, Shicai Su, Shuxia Chen, Ping Zhang, Rong Lu   +14 more
doaj   +1 more source