Results 71 to 80 of about 13,060 (191)

Locomotor activity and indirect calorimetry for MCT1^+/+ and MCT1^+/− mice fed a normal chow or high fat diet.

, 2013
(A) Vertical and horizontal movements of MCT1+/+ and MCT1+/− mice under normal chow. (B) Vertical and horizontal movements of MCT1+/+ and MCT1+/− mice under high fat diet. Filled bars, MCT1+/+ mice; open bars, MCT1+/− mice.
François Pralong (202345), Jean-Christophe Stehle (66239), Laure Dix (499052), Frédéric Preitner (499051), Bernard Thorens (120953), Pierre J. Magistretti (143663), Nadia Steiner (499049), Céline Favrod (499050), Lionel Carneiro (435208), Luc Pellerin (75905), Touria Nehiri-Sitayeb (499048), Sylvain Lengacher (499047)   +11 more
core   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Down regulation of MCT1 impairs long term memory in MCT1 ^+/- heterozygous mice.

, 2015
Step-through latencies were measured during IA training and retention testing (24 hours after the foot shock). Results are shown as mean ± SEM transfer latency responses. Baseline latency did not differ significantly across the two groups (p>0.05). MCT1+/
Igor Allaman (347102), Pierre J. Magistretti (143663), Gabriele Grenningloh (819731), Monika Tadi (819730), Sylvain Lengacher (499047)   +4 more
core   +1 more source

Lactate‐Responsive Glycogen Dynamics Are Associated With Bull Sperm Motility and Fertilization Under Glucose‐Limited Conditions

Andrology, EarlyView.
ABSTRACT Background Mammalian sperm need to undergo hyperactivation, capacitation, and acrosome reaction to achieve fertilization competence. However, the female reproductive tract presents contrasting metabolic environments. The uterus is glucose‐rich, and the oviduct is lactate‐rich and glucose‐limited.
Md Faizul Hossain Miraz, Takahiro Yamanaka, Takashi Umehara, Shahrina Akter, Wambugu Enoc Njoroge, Masayuki Shimada   +5 more
wiley   +1 more source

Localisation of Lactate Transporters in Rat and Rabbit Placentae

International Journal of Cell Biology, 2016
The distribution of monocarboxylate transporter (MCT) isoforms 1 and 4, which mediate the plasmalemmal transport of l-lactic and pyruvic acids, has been identified in the placentae of rats and rabbits at different ages of gestation.
Nigel P. Moore, Catherine A. Picut, Jeffrey H. Charlap   +2 more
doaj   +1 more source

Glucose deprivation stimulates monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration

, 2013
The glycolytic end-product lactate is a pleiotropic tumor growth-promoting factor. Its activities primarily depend on its uptake, a process facilitated by the lactate-proton symporter monocarboxylate transporter 1 (MCT1).
Cell Symposia: stem cell energetics, P E Porporato, Payen, V, Sonveaux, Pierre, BACR 2013, Sonveaux, P, Feron, Olivier, de Saedeleer, C, Brisson, Lucie, Porporato, P, Porporato, Paolo, Copetti, Tamara, Copetti, T, C J De Saedeleer, Perez Escuredo, Jhudit, T Copetti, Cell symposia: Mitochondria: from signaling to disease, P Sonveaux, J Pérez-Escuredo, BACR annual meeting, O Feron, L Brisson, Payen, Valéry, Pérez-Escuredo, J, Feron, O, De Saedeleer, Christophe, Annual mini-symposium of the Thematic Doctoral School in Experimental Oncology, V L Payen   +27 more
core   +1 more source

Monocarboxylate Transporters MCT1 and MCT4 Regulate Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells

, 2016
Objectives Novel treatments for pancreatic ductal adenocarcinoma (PDAC) are severely needed. The aim of this work was to explore the roles of H+-lactate monocarboxylate transporters 1 and 4 (MCT1 and MCT4) in PDAC cell migration and invasiveness. Methods
Kong, Su Chii, RESHKIN, Stephan Joel, Pedersen, Stine Helene Falsig, Nøhr Nielsen, Asbjørn, Hoffmann, Else Kay, Nøhr-Nielsen, Asbjørn, Novak, Ivana, Pedersen, Stine Falsig, ZEEBERG, KATRINE   +8 more
core   +1 more source

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

Body weight gain and food intake for MCT1^+/+ and MCT1^+/− mice fed high fat diet.

, 2013
(A) Evolution with time of body weight (B) Cumulative body weight gain (C) Weekly measured food intake (D) Cumulative food intake. Results represent mean ± SEM, n = 10–11. Filled circles, MCT1+/+ mice; open circles, MCT1+/− mice.
François Pralong (202345), Jean-Christophe Stehle (66239), Laure Dix (499052), Frédéric Preitner (499051), Bernard Thorens (120953), Pierre J. Magistretti (143663), Nadia Steiner (499049), Céline Favrod (499050), Lionel Carneiro (435208), Luc Pellerin (75905), Touria Nehiri-Sitayeb (499048), Sylvain Lengacher (499047)   +11 more
core   +1 more source