Results 91 to 100 of about 13,060 (191)

Diving into the unknown: Evidence of enhanced skeletal muscle lactate efflux potential and blood–muscle exchange in competitive breath‐hold divers

The Journal of Physiology, EarlyView.
Abstract figure legend Competitive breath‐hold divers exhibit skeletal muscle characteristics indicative of enhanced blood‐muscle exchange capacity and increased lactate efflux potential. Top left: Participant characteristics, matched for age, height, body mass, and maximal oxygen uptake (V̇O2max${\dot{\mathrm{V}}}\rm{O}_{\rm{2max}}$).
Antonis Elia, Matthew Lees, John O'Hara, Nathan Hodson, Jordan Acheson, Oliver Wilson, Paul Parker, Matthew Barlow   +7 more
wiley   +1 more source

Characterization of the Basigin-MCT1 Complex in Vertebrate Retina [PDF]

, 2008
It has been hypothesized that the cell adhesion molecule Basigin and the lactate transporter monocarboxylate transporter-1 (MCT1) interact to form a lactate shuttle necessary to fuel photoreceptor neurons in the retina.
Carson, Vilma S
core   +1 more source

Role of rno-miR-124-3p in regulating MCT1 expression in rat brain after permanent focal cerebral ischemia

Genes and Diseases, 2019
This study aimed to assess the role of microRNAs (miRNAs) in regulating monocarboxylate transporter-1 (MCT1) expression in rat brain after permanent focal cerebral ischemia to identify a new target for early treatment of cerebral ischemia. Focal cerebral
Shi-ye Xu, Xu-li Jiang, Qian Liu, Jin Xu, Juan Huang, Sheng-wei Gan, Wei-tian Lu, Fei Zhuo, Mei Yang, Shan-quan Sun   +9 more
doaj   +1 more source

Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation

The Journal of Physiology, EarlyView.
Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min, Órlaith C. Henry, Luke A. J. O'Neill   +2 more
wiley   +1 more source

Characterization of Mct1 expression patterns in cells transfected with full length and deletion mCherry-Mct1 expression constructs.

, 2014
A. Protein motifs in the C and N termini of Mct1 that could be involved in controlling its localization to vesicles include (in red); type 1 and 4 WW ligands, an AP2 clathrin interaction site, a PDZ ligand, a hydrophobic N terminus, a charged C terminus (
Jeffrey P. Smith (509882), Micah J. Velasquez (509881), Amy L. Uhernik (509879), Nathan LaVoy (509880), Lun Li (155358)   +4 more
core   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Expression of monocarboxylate transporter 1(MCT1) in the dog intestine [PDF]

ArticleIn this study, the expression and distribution of monocarboxyolate transporter 1 (MCT1) along the intestines (duodenum, jejunum, ileum, cecum, colon and rectum) of dogs were investigated at both the mRNA and protein levels.
4493, 松田, 一哉, KAWASAKO, Kazufumi, 岩野, 英知, 9440, 5717, 5718, 5719, 岡本, 実, SHIMOYAMA, Yumiko, 9417, 5714, 5715, 5716, TANIYAMA, Hiroyuki, 9431, KOMINE, Misa, KIRAT, Doaa, KATO, Seiyu, HIRAYAMA, Kazuko, MATSUDA, Kazuya, 4653, 4873, 5720, 5721, AKIHARA, Yuko   +25 more
core  

Disruption of Lactate Metabolism in the Peripheral Nervous System Leads to Motor‐Selective Deficits

Glia, Volume 74, Issue 12, December 2026.
To test the importance of lactate metabolism and shuttling between Schwann cells and neurons in the PNS, we selectively knocked out both LDHA and LDHB in motor neurons, sensory neurons, or Schwann cells. ABSTRACT Schwann cells (SCs) myelinate and provide trophic support to axons in the peripheral nervous system (PNS).
A. Joseph Bloom, Shweta Tendulkar, Amber R. Hackett, Amy Strickland, Yurie Sato‐Yamada, Liya Yuan, Wendy Dong, Joseph Ippolito, Robert E. Schmidt, Yo Sasaki, Aaron DiAntonio, Jeffrey Milbrandt   +11 more
wiley   +1 more source

Basigin mediation of  Plasmodium falciparum red blood cell invasion does not require its transmembrane domain or interaction with monocarboxylate transporter 1.

PLoS Pathogens
Plasmodium falciparum invasion of the red blood cell is reliant upon the essential interaction of PfRh5 with the host receptor protein basigin. Basigin exists as part of one or more multiprotein complexes, most notably through interaction with the ...
Nadine R King, Catarina Martins Freire, Jawida Touhami, Marc Sitbon, Ashley M Toye, Timothy J Satchwell   +5 more
doaj   +1 more source

Short‐Term Unacylated Ghrelin Administration Improves Pyruvate Tolerance Without Chronically Altering Skeletal Muscle, Liver, or Adipose Tissue Insulin Response in Healthy Rats

The FASEB Journal, Volume 40, Issue 21, 15 November 2026.
Unacylated ghrelin (unAG) has been previously shown to acutely increase fatty acid oxidation (FAO) in skeletal muscle. 5 days of unAG administration to healthy male rats improved pyruvate tolerance, however this was not associated with changes in hepatic glucose‐production associated proteins.
Nicole M. Notaro, Sofia F. Prizio, Brielle R. Caruso, David J. Dyck   +3 more
wiley   +1 more source