Results 91 to 100 of about 10,143 (187)

Interfering cellular lactate homeostasis overcomes Taxol resistance of breast cancer cells through the microRNA-124-mediated lactate transporter (MCT1) inhibition

Cancer Cell International, 2019
Background Breast cancer, the most common invasive cancer of women, is a malignant neoplasm and the second main cause of cancer death. Resistance to paclitaxel (Taxol), one of the frequently used chemotherapy agents for breast cancer, presents a major ...
Lu Hou, Yi Zhao, Guo-qing Song, Ying-han Ma, Xiao-hu Jin, Si-li Jin, Yi-han Fang, Yi-chong Chen   +7 more
doaj   +1 more source

Quantitative Imaging of Pyruvate Metabolism in a Patient With Anaplastic Thyroid Cancer

Magnetic Resonance in Medicine, Volume 96, Issue 2, Page 826-838, August 2026.
ABSTRACT Purpose Magnetic resonance imaging using hyperpolarized (HP) [1‐13C]‐pyruvate enables assessment of pyruvate metabolism in vivo and offers new insight into metabolic changes in response to cancer therapy. Widely used semi‐quantitative metrics of pyruvate metabolism can be affected by physiological factors that are extrinsic to intracellular ...
James A. Bankson, Joshua S. Niedzielski, Collin J. Harlan, Yunyun Chen, Christopher M. Walker, Philip L. Lorenzi, Lin Tan, Vikas Kundra, Matthew E. Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B. Peterson, Clifton D. Fuller, Vlad C. Sandulache, Stephen Y. Lai   +18 more
wiley   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Evidence that S‐phase kinase associated protein 2 (SKP2) is ubiquitinated and degraded via a Rho‐related BTB domain containing 1 (RhoBTB1) and Cullin‐3 mechanism in placenta

Physiological Reports, Volume 14, Issue 15, August 2026.
Graphical representation of mechanism by which RhoBTB1 regulates SKP2. Abstract Rho related BTB domain containing 1 (RhoBTB1) is highly expressed in placenta and functions to deliver protein targets to the Cullin‐3 (CUL3) E3 ubiquitin ligase where they are targeted for ubiquitination and degradation.
Alina L. Tvina, M. Christine Livergood, Gaurav Kumar, Valerie W. Hole, Megan A. Opichka, Luisangeli Muniz Irizarry, Ko‐Ting Lu, Kelsey K. Wackman, Justin L. Grobe, Pablo Nakagawa, Jennifer J. McIntosh, Curt D. Sigmund   +11 more
wiley   +1 more source

MCT1‐mediated Lactate Shuttle to Mitochondria Governs Macrophage Polarization and Modulates Glucose Homeostasis by Affecting β Cells

Advanced Science
As a major fuel source for the tricarboxylic acid cycle, lactate controls energy metabolism through cell‐to‐cell or tissue‐to‐tissue lactate shuttles via monocarboxylate transporters (MCTs). Although lactate is shown to influence macrophage functions via
Lingling Chen, Yijun Lin, Xinyu Zhu, Shixuan Zhuo, Zixuan Li, Cheng Guo, Xiaoyi Ye, Jinzhu Chen, Shuying Wang, Yan Chen   +9 more
doaj   +1 more source

Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation

Molecular Medicine
Background The terminal stage of ischemic heart disease develops into heart failure (HF), which is characterized by hypoxia and metabolic disturbances in cardiomyocytes.
Longfei Xu, Miaomiao Yang, Aili Wei, Zilin Wei, Yingkai Qin, Kun Wang, Bin Li, Kang Chen, Chen Liu, Chao Li, Tianhui Wang   +10 more
doaj   +1 more source

Towards the synthesis and delivery of a halogenated MCT1 substrate

, 2019
The monocarboxylate transporter 1 (MCT1) has received special attention as a potential therapeutic target in cancer thanks to its role in lactate shuttling. In breast cancer (BC), high MCT1 expression has been correlated with basal-like phenotype and a ‘triple-negative’ status, an aggressive subgroup of tumours with no identified molecular targets. In
openaire   +2 more sources

MCT1 Geninin Sporcu Performansıia Etkisi: Derleme Calismasi

Gazi Medical Journal, 2021
BULĞAY, CELAL, ZORBA, ERDAL, ERGÜN, MEHMET ALİ   +2 more
openaire   +2 more sources

A basigin antibody modulates MCTs to impact tumor metabolism and immunity

Cell Discovery
Lactate metabolism and signaling intricately intertwine in the context of cancer and immunity. Basigin, working alongside monocarboxylate transporters MCT1 and MCT4, orchestrates the movement of lactate across cell membranes.
Heng Zhang, Xuemei Yang, Yue Xue, Yi Huang, Yingxi Mo, Yurun Huang, Hong Zhang, Xiaofei Zhang, Weixin Zhao, Bin Jia, Ningning Li, Ning Gao, Yue Yang, Dongxi Xiang, Shan Wang, Yi Qin Gao, Jun Liao   +16 more
doaj   +1 more source

Monocarboxylate transporter 1 (MCT1) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source